Clinical trials: Crystalloid Solution
Sepsis
Study of Treatment's Echocardiographic Mechanisms
This ancillary study determines whether the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) [ClinicalTrials.gov Identifier: NCT03434028] treatment arms (restrictive fluids strategy vs.
- Trial name
- NCT03913403
- Testing
- ECHO, Blood Draw
- Where
- 7 sites in United States
- Volunteers
- 210 people
- Sponsor
- Intermountain Health Care, Inc.
Anesthesia, Spinal, Cesarean Section
Combined Colloid Preload And Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery
The study will compare one technique of fluid administration (combined colloid preload and crystalloid colaod) with another one (crystalloid coload) during elective cesarean delivery performed under spinal anesthesia.
- Trial name
- NCT02961842
- Testing
- 500 mL Colloid Preload, Spinal Anesthesia, Intrathecal Bupivacaine
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Cesarean Section
Fluid Volume-hypotension Association in Cesarean Under Neuraxial Anesthesia
Hypotension resulted from neuraxial block is a common problem, of which is a special issue in patients undergoing Cesarean section.
- Trial name
- VOHOCUNA (NCT01013090)
- Testing
- Ringer's Lactate, Six percent hydroxyethyl starch
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing Medical University
Trauma, Hemorrhagic Shock
Control of Major Bleeding After Trauma Study
Bleeding is the most avoidable cause of death in trauma patients. Up to one-third of severely injured trauma patients are found to be coagulopathic and forty percent of the mortality following severe injury is due to…
- Trial name
- COMBAT (NCT01838863)
- Testing
- Type AB plasma, Crystalloid fluid (standard of care for resuscitation)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Denver Health and Hospital Authority
Circulatory Failure
Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance
Acute circulatory failure reduces oxygen delivery below cellular requirements, potentially leading to organ failure. Intravenous fluids are generally administered with the aim of increasing cardiac output and restore organ…
- Trial name
- EXHALE (NCT04037644)
- Testing
- Fluid loading with Albumin, Fluid loading with Ringer Lactate
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milan
Sepsis
Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis
Fluid resuscitation of severe sepsis may consist of natural or artificial colloids or crystalloids. There is no evidence-based support for one type of fluid over another.
- Trial name
- NCT00799916
- Testing
- Resuscitation (Voluven), Resuscitation (Saline)
- Where
- 3 sites in Argentina
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de La Plata
Gastroenteritis Acute, Dehydration
Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis
Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy.
- Conditions
- Gastroenteritis Acute, Dehydration, Acidosis, Metabolic, Diarrhea
- Trial name
- NCT07610382
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Aydin Adnan Menderes University
Acute Respiratory Distress Syndrome (ARDS), Hypovolemia
Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)
The need for fluid resuscitation (FR) in ICU patients with acute respiratory distress syndrome (ARDS) is common. Indeed, relative or absolute hypovolemia is a common phenomenon that the intensivist must recognize early and treat…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypovolemia, Pulmonary Edema
- Trial name
- IROCA (NCT01763853)
- Testing
- 4% albumin
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnancy, Cesarean Delivery
Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia
Transthoracic echocardiography (TTE) has been introduced in anesthesia and intensive care practice to assess the volume status and predict fluid responsiveness, with a few studies performed on pregnant women (5).
- Conditions
- Pregnancy, Cesarean Delivery, Spinal Anesthesia Induced Hypotension, Cardiac Output Measurement
- Trial name
- NCT06654687
- Testing
- Transthoracic Echocardiography, Ringer lactate 1000 ml, Albumin
- Where
- Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Sameh Fathy
Aortic Valve Disease, Valve Disease, Heart
Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement
The goal of this clinical trial is to compare del Nido and Bretschneider-HTK (HTK) cardioplegia solutions in patients undergoing elective aortic valve replacement.
- Conditions
- Aortic Valve Disease, Valve Disease, Heart, Cardiac Ischemia
- Trial name
- NCT06235424
- Testing
- Del Nido Cardioplegia Solution, HTK solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Heart Disease
Dextran-based Priming vs. Crystalloid and Mannitol-based Priming Solution in Adult Cardiac Surgery
This study will compare two priming solutions for extracorporeal circulation, one based on Dextran 40, one based on crystalloid and mannitol. Primary endpoint is oncotic pressure during cardiopulmonary bypass.
- Trial name
- NCT02767154
- Testing
- A colloid Dextran 40 solution for extracorporeal circulation, Ringer-Acetate and Mannitol
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Sahlgrenska University Hospital
Pregnancy, Cesarean Delivery
Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia
The study aims to compare crystalloid co-loading and colloid co-loading in parturients receiving prophylactic phenylephrine infusion during cesarean delivery in terms of the incidence of hypotension.
- Conditions
- Pregnancy, Cesarean Delivery, Hypotension
- Trial name
- NCT03729076
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Bloodloss
This Study Will Compare the Effect of Starch Containing to Non-Starch Containing Intravenous Fluid on Blood Loss During Coronary Artery Bypass Graft Surgery
The overall aim of this study is to determine if there is a bleeding risk associated with the use of starch-containing fluids during cardiac surgery.
- Trial name
- NCT00801190
- Testing
- HES (130/0.4), Ringer's Lactate
- Volunteers
- 500 people
- Sponsor
- St. Boniface Hospital
Shock
Different Crystalloids on AKI in Shock
The goal is to observe that the incidence of acute kidney injury in patients who need fluid resuscitation when resuscitated with saline or acetated Ringer's sodium.
- Trial name
- NCT03155126
- Testing
- Fluid resuscitation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Southeast University, China
Postoperative Complications
Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)
Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia.
- Trial name
- COIN (NCT05728645)
- Testing
- Hydroxyethyl Starch 130/0.4 and Electrolyte injection of 5ml/kg, Multiple Electrolytes injection of 5 ml/kg
- Where
- China
- Volunteers
- 2,022 people
- Sponsor
- Xijing Hospital
Septic Shock
Albumin and Crystalloid Administration in Septic Shock
The current guideline emphasizes fluid resuscitation as the mainstay of initial management for septic shock. Albumin has the oncotic activity to maintain intravascular volumes with additional beneficial properties in sepsis.
- Trial name
- ALCAMIST (NCT05148286)
- Testing
- Treatment
- Where
- South Korea
- Volunteers
- 2,426 people
- Sponsor
- Asan Medical Center
Sepsis, Septic Shock
Strong Albumin Solutions in Patients With Septic Shock
Sepsis is an increasingly recognised burden to healthcare systems worldwide. Intravenous fluid therapy is a common first-line intervention recommended by international guidelines.
- Conditions
- Sepsis, Septic Shock, Shock, Toxic
- Trial name
- SWIPE2 (NCT05208242)
- Testing
- hyperoncotic human albumin solution, Buffered crystalloid solutions
- Where
- 2 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- Manchester University NHS Foundation Trust
Cardiac Arrest, Pulseless Electrical Activity
Surviving PEA in Roanoke (SPEAR) Study
The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless…
- Trial name
- SPEAR (NCT05283850)
- Testing
- High Calcium, Low Sodium (HCLS) Crystalloid Therapy, High Calcium, High Sodium (HCHS) Crystalloid Therapy
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Carol Bernier
Traumatic Brain Injury (TBI) Patients
Saline Versus Balanced Crystalloid in Traumatic Brain Injury
The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients.
- Trial name
- FLUID-TBI (NCT06953674)
- Testing
- Normal Saline (0.9% NaCl), balanced crystalloid
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Louisville
Coronary Artery Disease
Antegrade Autologous Blood Reinfusion After CPB
This prospective observational study aims to evaluate the effect of antegrade pump blood reinfusion using the crystalloid "chase" technique on postoperative transfusion requirements in adult patients undergoing cardiac surgery…
- Trial name
- NCT07420582
- Testing
- Antegrade Pump Blood Reinfusion, No Anterograde Pump Blood Reinfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Kocaeli City Hospital