Clinical trials: Critically Ill Patients, open to volunteers
Mechanical Ventilation
The Geniohyoid Muscle in Critical Illness
Many patients lose muscle due to being unwell in an intensive care unit. This muscle loss can lead to weakness of the arms and legs when they leave the unit, and when they go home.
- Trial name
- NCT07606690
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Warrington Hospital
Bacterial Sepsis
Therapeutic Monitoring of Beta-lactams in Critically Ill Patients With Sepsis
Background: Sepsis is a leading cause of morbidity and mortality among critically ill patients and is associated with intensive use of β-lactam antibiotics.
- Trial name
- NCT07270523
- Testing
- Individualized dosing of beta-lactam antibiotics based on therapeutic monitoring
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Critical Illness, Recovery Outcomes
Improving Survivorship for Critically Ill Patients Aged 65 and Over
IMPROVE-65 is a randomised control trial designed specifically for people aged over 65 who have survived critical illness. It aims to support patients and general practitioners by providing timely, personalised information to…
- Conditions
- Critical Illness, Recovery Outcomes, Care Coordination
- Trial name
- IMPROVE-65 (NCT07175961)
- Testing
- Multicomponent telehealth care coordination
- Where
- 2 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Psychological Disorder, Critical Illness
Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Studies in hospitalized patients have shown that a large percentage of them consider religion or spirituality to be an important factor in enabling them to cope with a serious illness.
- Trial name
- NCT06048783
- Testing
- Program of systematic and periodic spiritual accompaniment and care
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Diabetes Mellitus, Blood Sugar
Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit
Researchers at the Department of Intensive Internal Medicine and the Department of Endocrinology and Diabetology will conduct a study to verify the accuracy and safety of the new Syai Tag system for continuous glucose monitoring…
- Conditions
- Diabetes Mellitus, Blood Sugar, Sepsis, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT07448805
- Testing
- continuous glucose monitor
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Metabolism and Nutrition Disorder
Amino Acid Metabolism in Fed Surgical Critically Ill Patients
Introduction Sarcopenia is defined as progressive generalized loss of skeletal muscle mass, strength and function. Sarcopenia due to lack of physical activity is a known phenomenon and is usually observed as a normal part of…
- Trial name
- NCT03451968
- Testing
- amino acid tracer injection for metabolism analysis
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Critical Illness, Ventilated Patients
Critical Illness After Hematopoietic Cell Transplantation
This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation.
- Conditions
- Critical Illness, Ventilated Patients, Hematopoetic Stem Cell Transplantation, Transplant Complication
- Trial name
- CARE-HCT (NCT07328724)
- Where
- 6 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Peking University People's Hospital
Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients
This clinical trial aims to investigate whether the low treatment intensity (12 mL/kg/hr, low-dose hemodialysis/filtration) or the medium treatment intensity (25 mL/kg/hr, standard-dose hemodialysis/filtration) is more effective…
- Trial name
- LIMIT (NCT06014801)
- Testing
- Dialysate fluid, Filtration replacement fluid
- Where
- 9 sites in Japan
- Volunteers
- 400 people
- Sponsor
- Jikei University School of Medicine
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Sepsis, Bloodstream Infections
Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a Single-centre, Prospective, Observational Study
The purpose of this study is to investigate the efficacy of droplet digital PCR (ddPCR) in identifying pathogenic organisms in ICU sepsis patients, aiming to find a method that allows early identification of pathogenic organisms…
- Conditions
- Sepsis, Bloodstream Infections, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT06791889
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness, Near-Death Experience
Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room
This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who…
- Conditions
- Critical Illness, Near-Death Experience, Consciousness, Loss of, Quality of Life
- Trial name
- NCT06362525
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Orotracheal Intubation
AI-Integrated 3D-Printed Videolaryngoscope for Orotracheal Intubation in Critically Ill Patients
Background: Orotracheal intubation is an essential procedure in critically ill patients requiring ventilatory support, and the use of videolaryngoscopy is recommended as the gold standard in clinical practice.
- Trial name
- VL-AI (NCT07592702)
- Testing
- Orotracheal intubation using a 3D videolaryngoscope integrated with artificial intelligence (VL-IA)., Commercially available gold-standard videolaryngoscope (VL-C)
- Where
- 4 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of Pelotas
Hospital Acquired Pneumonia
Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype
Determine the efficacy of dexamethasone plus standard of care (SOC) as compared to placebo plus SOC for treating severe hospital-acquired pneumonia in critically ill patients with a proinflammatory phenotype; It's an…
- Trial name
- HAP-DEX (NCT06269900)
- Testing
- Dexamethasone
- Where
- 34 sites in France, Greece and 1 more
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Enteral Nutrition, Enteral Nutrition Feeding
Stepwise Enteral Nutritional Algorithm and Patient Outcomes in Pediatric Intensive Care Units
The aim of the study to evaluate the effectiveness and patient's outcome after implementing enteral nutrition algorithm designed to achieve optimal enteral nutrition delivery in the pediatric intensive care unit and to evaluate…
- Conditions
- Enteral Nutrition, Enteral Nutrition Feeding, Enteral Nutrition Intolerance in Critically Ill Patients
- Trial name
- NCT07307027
- Testing
- Stepwise Enteral Nutritional Algorithm
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Fungal Infection, Aspergillosis
Isavuconazole in Critically Ill Patients: Efficacy and Safety
Due to factors such as disease status, gastrointestinal conditions, commonly used medications (e.g., vasopressors), and cardiac output, the plasma concentration of isavuconazole in critically ill patients may differ from that in…
- Conditions
- Fungal Infection, Aspergillosis, Mucormycosis
- Trial name
- NCT07080359
- Testing
- Isavuconazole treatment
- Volunteers
- 75 people
- Sponsor
- Shanghai 10th People's Hospital