Clinical trials: Critically Ill
Frailty, Delirium Confusional State
Patients With Long-stay at ICU: Factors and Evaluation - Feasibility Study
Every year, many critically ill patients are admitted to an intensive care unit (ICU). Most stay only a few days, but a smaller group stays much longer.
- Conditions
- Frailty, Delirium Confusional State, Persistent Critical Illness, Post-Intensive Care Syndrome
- Trial name
- LIFE-ICU (NCT07851974)
- Where
- 4 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Critical Illness
The Impact of Higher Positive End Expiratory Pressure on Patient-Ventilator Asynchrony
Patient-ventilator asynchrony is known to frequently occur during lung protective ventilation in patients with ARDS. Previous clinical studies showed that patient-ventilator asynchrony was associated with worse outcome in ICU.
- Trial name
- NCT04951960
- Testing
- Higher PEEP setting, Lower PEEP setting
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Osaka University
Cirrhosis
To Determine the Role of Prokinetics in Feed Intolerance in Critically Ill Cirrhosis
1. All patients with chronic liver disease admitted in ICU (Intensive Care Unit) to be screened. 2. Patients fulfilling criteria for feed intolerance to be included in the study. 3.
- Trial name
- NCT02528760
- Testing
- Metaclopramide, Erythromycin
- Where
- India
- Volunteers
- 83 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Critical Illness, Sepsis
Systemic Immune-Inflamation Index and Mortality in ICU Patients
Systemic Immune-Inflammation Index (SII) is a hemogram-derived biomarker reflecting the balance between systemic inflammation and immune response.
- Trial name
- NCT07493759
- Testing
- Systemic Immune-Inflammation Index (SII)
- Where
- Turkey (Türkiye)
- Volunteers
- 570 people
- Sponsor
- Ataturk University
Systemic Inflammation
Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients
Studies showed that infusion or injection of drugs and fluids results in introduction of microparticles into the bloodstream. These microparticles may cause organ damage and stimulate the immune system thus aggravating the…
- Trial name
- NCT01534390
- Testing
- In-line microfilter (Supor IV Filter; Pall Corporation, Port Washington, New York)
- Where
- Austria
- Volunteers
- 504 people
- Sponsor
- University of Salzburg
Critically Ill, Hypoglycemia
The Efficacy of Glucagon Like Peptide (GLP) - 1(7-36) Amide for Glycemic Control in Critically Ill Patients
The goal of this present proposal is to examine the efficacy of GLP-1 administered to control blood glucose in critically ill patients.
- Trial name
- NCT00798590
- Testing
- Glucagon-Like Peptide-1, Saline
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Infection
Colistin Pharmacokinetics in Continuous Renal Replacement Therapy
The blood concentration of the antibiotic colistin is determined in patients in whom kidney function is reduced such that a renal replacement therapy is needed.
- Trial name
- NCT02081560
- Testing
- Colistin
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
CMV
Cytomegalovirus Infection in Critically Ill Patients and Patients Receiving Anticancer Therapy
Cytomegalovirus (CMV) is the most common member of the herpes viruses to infect humans. Its double-stranded linear DNA duplex contains 165 genes that encode viral proteins that mimic and interact with human cellular proteins and…
- Trial name
- CMV-ICU (NCT04280380)
- Testing
- Real time PCR
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundación de investigación HM
Post-Traumatic Stress Disorder
Intensive Care Unit (ICU) Diaries as a Therapeutic Intervention for Post Traumatic Stress Disorder (PTSD) Following Critical Illness
The incidence of PTSD post ICU varies from unit to unit, however a significant number of patients have been shown to develop this disorder.
- Trial name
- RACHEL II (NCT00912613)
- Testing
- ICU Diary
- Volunteers
- 352 people
- Sponsor
- University of Liverpool
Critical Illness
KetAmine and Recovery After Mechanical VentilAtion ( KARMA )
Invasive mechanical ventilation of critically ill patients in the intensive care unit (ICU) is associated with significant morbidity and mortality, as well as a severe prognosis in survivors, in terms of functional…
- Trial name
- KARMA (NCT07590687)
- Testing
- Intervention Group
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Role of Renal Artery Doppler in Critically Ill Children With Acute Kidney Injury
To detect frequency of acute kidney injury in critically ill children in Assuit university hospital. To detect associated AKI risk factors, severity and outcomes . To assess the value of use of renal Doppler ultrasound in AKI.
- Trial name
- NCT06202326
- Testing
- renal artery doppler
- Volunteers
- 45 people
- Sponsor
- Assiut University
Shock, Critically Ill
Validation of the Fluid Responsiveness Index in Critically Ill Patients
Fluid therapy is an important part of the management of patients with hemodynamic instability in the intensive care unit. By increasing cardiac preload, it aims at elevating cardiac output (CO) and thus restoring hemodynamic…
- Trial name
- FRI (NCT00894309)
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- Bicetre Hospital
In-Hospital Cardiac Arrest
Derivation of An In-Hospital Cardiac Arrest Prediction Model for Patients in Intensive Care Unit
Current studies have shown that hospitalized ICU patients have a high risk of IHCA, with an incidence of about 0.6-7.8%. Early prediction of the occurrence of IHCA in severe patients can provide early intervention, prevent the…
- Trial name
- NCT04670458
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Qilu Hospital of Shandong University
Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU
Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients
When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by…
- Trial name
- NCT07178626
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Hospital of Jilin University
Critical Illness, Malnutrition
Association Between Malnutrition and Clinical Outcomes in the Intensive Care Unit
Previous studies have demonstrated the direct associations between malnutrition and hospital mortality as well as the length of stay in critically ill patients.
- Trial name
- NCT03213899
- Volunteers
- 503 people
- Sponsor
- JurongHealth
Evidence-Based Nursing, Critically Ill Patient
Enhancing Critical Thinking Competency and Nursing Quality in Critically Ill Patient Care
The EBN-based nutritional management protocol effectively enhances junior nurses' specialized critical thinking competency and improves patient nutritional outcomes and satisfaction, demonstrating its potential to optimize…
- Conditions
- Evidence-Based Nursing, Critically Ill Patient, Training
- Trial name
- NCT06997614
- Testing
- Conventional group, evidence-based nursing group
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Taizhou Hospital
Critical Illness, Burnout, Professional
Multicenter Intensivist Weekend Scheduling Study
The care of critically ill patients in Intensive Care Units (ICUs) is an important part of modern health care systems. However, ICU care suffers from similar problems as the rest of the health care system.
- Trial name
- NCT01145443
- Testing
- Alternative Intensivist staffing models.
- Where
- 4 sites in United States
- Volunteers
- 1,945 people
- Sponsor
- University of Manitoba
Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired
FilmArray Pneumonia Panel for Antimicrobial Treatment of HAP/VAP in Intensive Care Units
Microbiologic diagnosis of pneumonia is often limited by a long turnaround time of cultures. This randomized trial aims to evaluate the impact of BioFire FilmArray Pneumonia panel on (1) the proportion of appropriate/optimal…
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired, Critically Ill
- Trial name
- FilmArray (NCT05214716)
- Testing
- FilmArray Pneumonia panel
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Kyungmin Huh
Poisoning by Inhaled Anaesthetic, Fluoride Poisoning
Sevoflurane- Safety in Long-term Sedation Procedures
Patients needing intensive care often require sedative drugs to reduce anxiety and agitation during ventilator care and invasive therapeutic and diagnostic procedures.
- Conditions
- Poisoning by Inhaled Anaesthetic, Fluoride Poisoning, Recovery From Sedation, Renal Function
- Trial name
- NCT01802255
- Testing
- Sevoflurane, Midazolam
- Where
- Spain
- Sponsor
- F Javier Belda
Burns
Massive Burns: Retrospective Analysis of Changes in Outcomes Across 18 Years
Burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (TBSA)).
- Trial name
- MassiveBurns (NCT04480944)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Mette M Berger