Clinical trials: Critical Illness Recovery
COVID-19, Critical Illness
Recovery of Patients From COVID-19 After Critical Illness
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality.
- Trial name
- NCT04401254
- Where
- 29 sites in Australia
- Volunteers
- 536 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
PICS, Anxiety
Behavioral Health Collaborative Care Model in an ICU Recovery Clinic
Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to…
- Conditions
- PICS, Anxiety, Depression - Major Depressive Disorder, Post-Traumatic Stress
- Trial name
- BeColM (NCT07372586)
- Testing
- Behavioral Health Collaborative Care Model
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina
Critical Illness, Recovery Outcomes
Improving Survivorship for Critically Ill Patients Aged 65 and Over
IMPROVE-65 is a randomised control trial designed specifically for people aged over 65 who have survived critical illness. It aims to support patients and general practitioners by providing timely, personalised information to…
- Conditions
- Critical Illness, Recovery Outcomes, Care Coordination
- Trial name
- IMPROVE-65 (NCT07175961)
- Testing
- Multicomponent telehealth care coordination
- Where
- 2 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Sleep Deprivation
Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care Unit
Sleep deprivation in healthy volunteers is associated with immune dysfunction. This adverse effect of sleep deprivation likely occurs in patients suffering from acute injury and critical illness requiring intensive care unit…
- Trial name
- NCT01082016
- Testing
- Sleep Enhancement Program (SEP)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Arizona
Critical Illness Myopathy, Myopathy Critical Illness
Understanding the Mechanisms of Critical Illness Myopathy by Use of a Novel Electrophysiological Method - MVRCs
Critical illness myopathy (CIM) is a disabling condition that develops in critically ill patients. The syndrome is not only a cause of prolonged intensive care hospitalisation but also a main reason for delayed recovery.
- Trial name
- NCT04711070
- Where
- 2 sites in Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Post Intensive Care Unit Syndrome, Critical Illness
Improving Recovery After Critical Illness
Rationale: Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Critical Illness, Malnutrition, Muscle Weakness
- Trial name
- IMPROVE (NCT05182086)
- Testing
- Group physical therapy and dietary improvements
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum
Critical Illness, Acute Respiratory Distress Syndrome
TelePORT Pilot Study
Although more than 50% of survivors of critical illness experience one or more post-intensive care syndrome (PICS) problems, there are still no validated interventions for the management of PICS.
- Conditions
- Critical Illness, Acute Respiratory Distress Syndrome, Septic Shock
- Trial name
- TelePORT (NCT03926533)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Vanderbilt University
Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome
Combined Activity and Cognitive Intervention for ICU Survivors
This mixed-methods study comprising a 3-arm pilot RCT and a qualitative study aims to investigate the preliminary effects and feasibility of a home-based combined activity and cognitive intervention for ICU survivors…
- Conditions
- Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome, Delirium, Loss of Muscle Mass
- Trial name
- NCT06117761
- Testing
- Home-based exercises combined with cognitive training, Home-based exercises
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Trauma, Critical Illness
Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery
This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients.
- Trial name
- NCT06521086
- Testing
- Nutrition Supplements - Fresubin KCAL Drinks
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University