Clinical trials: Critical Illness Recovery
Traumatic Brain Injury, Critical Illness
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity.
- Conditions
- Traumatic Brain Injury, Critical Illness, Sleep
- Trial name
- SMARTKids (NCT04932096)
- Testing
- melatonin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Critical Illness
A Study to Investigate the Effect of HMB on Skeletal Muscle Wasting in Early Critical Illness
This study aims to investigate the effect of beta-hydroxy-beta-methylbutyrate (HMB) on skeletal muscle wasting, physical function, strength and quality of life in survivors of critical illness.
- Trial name
- HMB-ICU (NCT03464708)
- Testing
- HMB
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sepsis, Post Intensive Care Unit Syndrome
Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.
The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU…
- Conditions
- Sepsis, Post Intensive Care Unit Syndrome, Critical Illness, Microbiome Dysbiosis
- Trial name
- PAM-ICU (NCT07295353)
- Testing
- Pasteurized Akkermansia muciniphila
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Alcohol Use Disorder (AUD)
A Critical Illness Recovery Navigator for Alcohol
Excessive alcohol consumption is common in patients admitted to the intensive care unit (ICU). Among patients who survive an ICU admission, excessive alcohol consumption is associated with a higher risk of being admitted the…
- Trial name
- CIRNA (NCT03059082)
- Testing
- Recovery Navigator on an as needed basis up to 6 months, Recovery Navigator prior to hospital discharge, No interaction with Recovery Navigator
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Critical Illness, Recovery Outcomes
UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.
Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients.
- Conditions
- Critical Illness, Recovery Outcomes, Critical Care, Intensive Care, Critical Care
- Trial name
- UPSt_UCI (NCT07510776)
- Where
- 7 sites in Portugal
- Volunteers
- 7,000 people
- Sponsor
- Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Intensive Care Unit Syndrome
ICU Recovery in Australian Patients
Increasingly patients with critical illness requiring life support in an intensive care unit are surviving their hospital admission.
- Trial name
- ICU-RECOVERY (NCT02225938)
- Where
- 5 sites in Australia
- Volunteers
- 262 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness Recovery, Pulmonary Rehabilitation
Impact of 3D-EIT-Guided Acapella Breathing Training on Lung Ventilation Distribution
The goal of this randomized clinical trial is to determine whether real-time visual feedback from three-dimensional electrical impedance tomography (3D-EIT) can improve the effects of Acapella breathing exercises in adults…
- Trial name
- NCT07733843
- Testing
- Acapella Oscillating Positive Expiratory Pressure Breathing Exercise, Real-Time 3D Electrical Impedance Tomography Visual Biofeedback
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
I-WEAR: Evaluating Wearables and Health Summaries in ICU Survivors
This pilot study investigates the use of wearable health technology and bi-weekly digital health summaries in patients recovering from intensive care.
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Coronary Artery Disease
- Trial name
- I-WEAR (NCT07035106)
- Testing
- Wearable Health Monitoring, Digital Health Summary and Lifestyle Counseling
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Critical Illness, Intensive Care
Early Exercise Training in Critically Ill Patients
This randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged ICU stay, could induce a…
- Conditions
- Critical Illness, Intensive Care, Muscle Weakness, Deconditioning
- Trial name
- NCT00695383
- Testing
- Bedside cycle exercise therapy, Standard physiotherapy program
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Critical Illness, Mechanical Ventilation
Proof of Concept Trial to Confirm That the Recovery of Patients Treated in the Intensive Care Unit Requiring Mechanical Ventilation is Beneficially Affected by the Environmental Simulation of Daytime and Night Time Alternation as Well as by the Nutrition Protocol Corresponding to the Daily Rhythm
The purpose of this study is to determine whether the environmental simulation of daytime and night time alternation as well as by the nutrition protocol corresponding to the daily rhythm are beneficially affect the recovery of…
- Trial name
- NCT02828722
- Testing
- Controlled light and noise, Controlled nutrition
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Achros Health Technologies Corporation
Critically Ill, ICU Survivor
The ICU-recover Box, Using Smart Technology for Monitoring Health Status After ICU Admission
In this pilot study we will study the feasibility of providing and following ICU patients with smart technology for three months after discharge from a general ward of the Leiden University Medical Centre.
- Conditions
- Critically Ill, ICU Survivor, User Experience
- Trial name
- NCT05766319
- Testing
- Withings ScanWatch, Withings BPM Connect, Withings Body
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Leiden University Medical Center
Critical Illness, Illness, Critical
Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness
This is a prospective longitudinal study that will evaluate the unmet needs of older adults (65 and older) who return home (either directly or after short-term rehab) after an ICU hospitalization, evaluate the association of…
- Trial name
- LANTERN (NCT06006000)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Yale University
Intensive Care (ICU) Myopathy
Intermittent Versus Continuous Feeding in ICU Patients
The purpose of this study is to determine whether intermittent nasogastric enteral feeding, rather than conventional continuous enteral feeding, will preserve muscle mass in the critically ill (Primary end-point).
- Trial name
- NCT02358512
- Testing
- Enteral feeding
- Where
- 2 sites in United Kingdom
- Volunteers
- 127 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Critical Illness Myopathy, Critical Illness Polyneuropathy
Improved Recovery of Walking in Acquired Muscle Weakness
The aim of Re-Walk-Easy is to evaluate the effects of rehabilitation based on electrical stimulation on the motor performance of critically ill patients.
- Trial name
- Re-Walk-Easy (NCT06786390)
- Testing
- Rehabilitation protocol: FES, Rehabilitation protocol without FES
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Thrombocytopenia; Drugs
The Incidence of Linezolid-induced Thrombocytopenia (LIT) in Critically Ill Patients, the Risk Factors for LIT
To identify the incidence of LIT among critically ill patients, as limited studies have only addressed this population. To evaluate the impact of several factors on the incidence of LIT, the time to onset of LIT, and the time to…
- Trial name
- NCT05944445
- Testing
- Linezolid 600 mg
- Where
- Egypt
- Volunteers
- 310 people
- Sponsor
- Helwan University
Critical Illness
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients
This pilot study will study the impact of critical illness and ICU processes of care on the trajectory and development of frailty.
- Trial name
- FORECAST (NCT04605029)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. John Muscedere
COVID-19, Muscle Atrophy
Electrical Stimulation for Critically Ill Post-Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- COVID-19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase II (NCT05198466)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Poisoning by Inhaled Anaesthetic, Fluoride Poisoning
Sevoflurane- Safety in Long-term Sedation Procedures
Patients needing intensive care often require sedative drugs to reduce anxiety and agitation during ventilator care and invasive therapeutic and diagnostic procedures.
- Conditions
- Poisoning by Inhaled Anaesthetic, Fluoride Poisoning, Recovery From Sedation, Renal Function
- Trial name
- NCT01802255
- Testing
- Sevoflurane, Midazolam
- Where
- Spain
- Sponsor
- F Javier Belda
COVID-19
Rehabilitation in Severely Ill Inpatients With COVID-19
Inpatient rehabilitation of severe-to-critical COVID-19 patients(A longitudinal, single-center retrospective cohort)
- Trial name
- NCT05104411
- Testing
- Rehabilitative intervention
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Bundang Hospital
Pediatric Critical Illness
Functional Recovery in Critically Ill Children, the Wee-Cover Multicentre Study
When children suffer from a critical-illness, the investigators focus on resuscitating and saving lives. Once these children leave the pediatric intensive care unit, very little is known about what happens to them - how long it…
- Trial name
- NCT02148081
- Where
- 2 sites in Canada
- Volunteers
- 182 people
- Sponsor
- McMaster University