Clinical trials: Critical Illness Myopathy
Critical Illness Myopathy
Effects of Neuromuscular Electrical Stimulation on Exercise Capacity in Respiratory Critically Ill Patients
Neuromuscular electrical stimulation (NMES) implemented during the intensive care unit(ICU) stay may improve exercise capacity and prevent muscular weakness in critically ill patients with respiratory disease.
- Trial name
- NCT03083652
- Testing
- Neuromuscular electrical stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Critical Illness, Muscle Weakness
Progressive Mobility Program and Technology to Improve the Level of Physical Activity and Functionality of ICU Patients
The purpose of this study is to verify if a protocol of early and progressive mobility which includes the use of technology is able to increase the level of physical activity and improve functionality and respiratory and muscular…
- Trial name
- NCT02889146
- Testing
- Conventional Physical Therapy, Early and progressive mobilization program, Respiratory therapy
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo General Hospital
Sepsis, Myopathy Critical Illness
Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for Sepsis
Approximately 40% of patients develop muscle dysfunction during their stay in intensive care, particularly in the context of sepsis.
- Trial name
- REAMUS (NCT07074028)
- Testing
- Medical Research Council sum score (MRC-SS) test, Handgrip test combined with surface electromyography (sEMG), Electrical activity during maximal voluntary contraction of the rectus femoris
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Critical Illness Myopathy, Respiratory Paralysis
ICU Acquired Neuromyopathy and Diaphragm Function
Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation.
- Trial name
- NCT01968889
- Testing
- Non invasive phrenic nerve stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Patients Are Recruited From One Thoracic and Cardiac Surgery ICU
Study of Safety and Efficacy on Neuromyopathy of Early Standing With the Assistance of Tilt Table in Critically Patients
Critically ill patients frequently develop muscle weakness due to critical illness-related acute neuropathy and/or myopathy. This disorder is associated with difficulties in weaning from mechanical ventilation, prolonged…
- Trial name
- TILT (NCT02047617)
- Testing
- the standard physiotherapy group, standing table group
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Muscle Weakness, Critical Illness
Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Translation, and Validation Study.
Early mobilisation of the patient admitted to intensive care units (ICUs) is essential to prevent Intensive Care Unit Acquired Weakness (ICUAW).
- Conditions
- Muscle Weakness, Critical Illness, Critical Illness Recovery, Acquired Weakness
- Trial name
- NCT07195942
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Critical Illness, Intensive Care (ICU) Myopathy
Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial
An increasing number of patients survive critical illness and intensive care, but describe having impaired physical function several years after discharge as a consequence of extensive loss of muscle mass.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, Muscle Wasting, Loss of Physical Function
- Trial name
- EAT-ICU (NCT01372176)
- Testing
- Early Goal-Directed Nutrition, ASPEN-guidelines
- Where
- Denmark
- Volunteers
- 203 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
SARS-CoV-2 Acute Respiratory Disease, Sarcopenia
How COVID-19 Effects to Muscle Mass Change ın ICU?
Critical illness myopathy and neuropathy are associated with prolonged mechanical ventilation, resulting in increased morbidity and mortality in intensive care units, .the investigators aimed to determine the decrease in muscle…
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, Sarcopenia, ICU Acquired Weakness, Critical Illness Myopathy
- Trial name
- NCT05008562
- Testing
- COVID-19 RELATED MUSCLE MASS CHANGE IN THE INTENSIVE CARE UNIT
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ondokuz Mayıs University
Muscle Weakness, Critical Illness
Electromagnetic Stimulation of the Phrenic Nerve in Critically Ill Mechanically Ventilated Patients (STIMIT-II)
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication
- Trial name
- STIMIT-II (NCT05238753)
- Testing
- Non-invasive electromagnetic stimulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Burns - Multiple, Critical Illness
Reduction of Muscle Catabolism Through Brain Activation in Burn Patients
Patients with extensive burn injuries frequently develop severe skeletal muscle wasting and weakness as part of critical illness-related myopathy and neuropathy.
- Conditions
- Burns - Multiple, Critical Illness, Muscle Weakness
- Trial name
- REMBRANT (NCT07435402)
- Testing
- Burn-Bundle Extended Rehabilitation Program, Isoflurane Inhalational Sedation, Functional Proprioceptive Stimulation
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Charles University, Czech Republic
Critical Illness, Intra-Abdominal Hypertension
Intraabdominal Pressure in Critically Ill Patients
This study is conducted to evaluate the incidence and prognostic significance of IAH in medical ICU patients.
- Trial name
- NCT03670771
- Testing
- Harrahill method for measuring of intraabdominal pressure
- Volunteers
- 100 people
- Sponsor
- Assiut University
Critically Ill, Intra-Abdominal Hypertension
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function
Intra- abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are a cause of organ dysfunction in critically ill patients.
- Conditions
- Critically Ill, Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury
- Trial name
- NCT01077895
- Testing
- CVVH, ultrafiltration, ultrafiltration control group
- Where
- 2 sites in Belgium
- Sponsor
- University Hospital, Ghent
Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy
Critical Illness Weakness Outside the Intensive Care Unit.
When people become seriously ill, their bodies can be affected in many ways beyond the original disease. One well-known complication in patients treated in intensive care units (ICUs) is the development of severe muscle weakness…
- Conditions
- Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- CRI-WEAK-OUT (NCT07478367)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Brain Injuries, Dementia
ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit
Intensive care unit (ICU) hospitalization saves lives but often does so at a high personal cost to ICU survivors who frequently experience significant cognitive impairment and an array of physical and functional disabilities that…
- Conditions
- Brain Injuries, Dementia, Myopathies, Muscle Disorders
- Trial name
- ACT-ICU (NCT01270269)
- Testing
- Behavioral: Physical and functional rehabilitation, Behavioral: Cognitive, physical, & functional rehabilitation
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Vanderbilt University
Muscle Weakness, Critical Illness
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
Elderly patients who experience a prolonged ICU stay are at high risk for developing post intensive care unit syndrome (PICS), a serious medical condition manifested by loss of muscle mass, weakness, malnutrition and…
- Conditions
- Muscle Weakness, Critical Illness, Sarcopenia
- Trial name
- ExPrEs (NCT02509520)
- Testing
- MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Muscle Weakness
Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness
Assessment of Effectiveness of combined high protein intake with early physical exercise by ultrasound measurement of rectus femoris muscle thickness in Intensive Care Unite mechanically ventilated patients.
- Trial name
- NCT05877989
- Testing
- Amino Acid, Physical exercise
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University