Clinical trials: Craniofacial Abnormalities
Maxilla; Hypoplasia
Transverse Maxillary Expansion With a Segmental Le Fort I Osteotomy or Surgically Assisted Rapid Maxillary Expansion (SARME)
To assess transverse dental and skeletal expansion and stability after SLFIO with no fixation of the palatal vault compared to stabilization of the palatal vault with an autogenous bone block graft or fixation of the palatal…
- Trial name
- NCT03511989
- Testing
- Bone borne distractor, Tooth borne distractor, Segmental LF1 Osteotomy group 1
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Chromosome 22q11.2 Deletion Syndrome
Genetics and Psychopathology in the 22q11 Deletion Syndrome
The purposes of this study are to: 1. study the nature and longitudinal course of psychiatric symptoms in children with the 22q11.2 deletion syndrome and 2. identify genes that contribute to the occurrence of these symptoms.
- Trial name
- NCT00161109
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Dentofacial Deformities, Orthognathic Surgery
Quantitative Evaluation of Attention to Faces After Orthognathic Surgery With Eye-tracking
Dentofacial deformities refer to morphological anomalies of the jaws. Their development during growth determines the shape of the lower third of the face and the type of dental occlusion.
- Conditions
- Dentofacial Deformities, Orthognathic Surgery, Social Perception, Eye Tracking
- Trial name
- OCHIRO (NCT06494709)
- Testing
- photographs
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Skin Condition, Cleft Lip and Palate
Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study
A visible difference can have a profound impact in a society with a massive emphasis on appearance and "looks". A vulnerable group is adolescents with a condition affecting their appearance as a result of injuries (burns…
- Conditions
- Skin Condition, Cleft Lip and Palate, Burns, Other Conditions Leading to a Visible Difference
- Trial name
- UNGFaceIT (NCT03165331)
- Testing
- Ung Face IT
- Where
- Norway
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Maxillofacial Deformity, Maxillofacial Abnormalities
a Comparative Analysis of Subspinal and Conventional Le Fort I Osteotomy on Nasolabial Soft Tissues
Following surgical operations, patients have aesthetic expectations as well as functional ones. To minimize undesirable aesthetic results after surgery and to increase the effectiveness of the surgery, the surgical method used…
- Conditions
- Maxillofacial Deformity, Maxillofacial Abnormalities, Maxillo-facial Surgery
- Trial name
- NCT07549659
- Testing
- conventional le fort I osteotomy type, subspinal le fort I osteotomy type
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Facial Deformity, Implant Complication
Optimizing Surgical and Prosthetic Workflow for Implant-supported Ear and Nose Prostheses With Early Loading and Distant Prosthesis Fabrication: A Prospective Cohort Study
Facial defects created by trauma, oncological procedures or congenital conditions can be repaired with ear, nose and/or eye prostheses. These are fixed on intraosseous implants placed in the temporal, nasal and orbital bone.
- Trial name
- NCT06506695
- Testing
- Craniofacial implant placement
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Dentofacial Deformities
3D Photogrammetry Versus Commercial Scanners for Accurate Repositioning of the Maxilla for Correction of the Dentofacial Deformity.
Current advances in the three-dimensional virtual surgical planning (3D-VSP) of the orthognathic surgery have brought newer insights, enormous benefits and have become an indispensable aid for diagnosis, treatment planning and…
- Trial name
- NCT05755022
- Testing
- Maxillary Segment Repositioning
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Arthrogryposis, Craniofacial Abnormalities
Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions
The hypotheses of the present study of Freeman-Sheldon syndrome (FSS) and related conditions are: (1) that exercise capacity is lower in FSS patients versus normal controls, and the lower exercise capacity is due to changes in…
- Trial name
- FSS-EDICT I (NCT01306994)
- Testing
- Lactate, Glucose, and Adenosine Triphosphate Blood Levels, Physiological Stress Test, Functional Enquiry Form
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Freeman-Sheldon Research Group, Inc.
Skeletal Class II Malocclusion, Mandibular Retrognathia
Fixed Versus Conventional Twin Block Appliances for Skeletal Class II Malocclusion
This study compares two types of dental appliances a fixed Twin Block appliance and a conventional (removable) Twin Block appliance used to treat a bite problem called skeletal Class II malocclusion in growing children and…
- Trial name
- NCT07687927
- Testing
- Conventional Twin Block Appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Plagiocephaly
Postural Assessment in Plagiocephaly
The positional plagiocephaly is a condition involving craniofacial asymmetry. The purpose of this study is to evaluate the spine, the posture and the psychomotor state in children who were diagnosed with infant plagiocephaly.
- Trial name
- NCT01989286
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Surgical Complication, Paresthesia
Trial of Bilateral Sagittal Split Osteotomy Induced Paresthesia Using Ultrasonic vs. Reciprocating Saw Instrumentation
The aim of this prospective study is to analyze the postoperative paresthesias experienced in patients who undergo bilateral sagittal split osteotomies (BSSO) using an ultrasonic saw, versus a reciprocating saw.
- Conditions
- Surgical Complication, Paresthesia, Fracture, Nerve Injury
- Trial name
- NCT05205616
- Testing
- Sonopet ultrasonic saw, Reciprocating saw
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cleft Palate Children
Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery
Cleft lip and palate (CLP) is one of the most common congenital malformations and requires repeated surgical correction during childhood.
- Trial name
- NCT07279883
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dentofacial Deformity
Lower Laser Therapy in Orthognathics Surgery
This study will examine the use of lower laser therapy to reduce edema and pain in orthognathics surgery.
- Trial name
- NCT01530100
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Malocclusion, Craniofacial Morphology
Research on Deep Learning-Based Intelligent Diagnosis and Treatment
This study aims to develop and evaluate deep learning-based artificial intelligence models for craniomaxillofacial multi-modal imaging analysis and clinical decision support.
- Conditions
- Malocclusion, Craniofacial Morphology, Dentofacial Deformities
- Trial name
- NCT07551622
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Pregnant Women Requiring Amniocentesis
Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
Losses of imprinting are involved in various syndromes. Those occurring in the 11p15 region lead to Beckwith-Wiedemann and Silver-Russell Syndromes.
- Trial name
- DASIRUWIBE (NCT01842659)
- Testing
- Methylation Index
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cleft Lip and Palate, Maxillary Hypoplasia
Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Cleft lip and palate patients normally present with a sunken face due to collapse in the middle part of the face and inability of the upper and lower teeth to meet during chewing.
- Trial name
- NCT00930124
- Testing
- Orthognathic surgery, Distraction osteogenesis
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Craniofacial Abnormalities, Cleft Lip
FaceBase Biorepository
The purpose of this study is to find out if there are any genetic differences between people with and without disorders of the head, face, and eye.
- Conditions
- Craniofacial Abnormalities, Cleft Lip, Cleft Palate
- Trial name
- NCT01252264
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Jeff Murray
Plagiocephaly, Plagiocephaly, Nonsynostotic
Efficacy of Pediatric Manual Therapy in the Positional Plagiocephaly
This study evaluates the efficacy of Pediatric Manual Therapy in the treatment of positional plagiocephaly in infants. 40 participants will receive a protocol of Pediatric Manual Therapy and educational physiotherapy in…
- Conditions
- Plagiocephaly, Plagiocephaly, Nonsynostotic, Plagiocephaly, Positional
- Trial name
- NCT03659032
- Testing
- Pediatric Manual Therapy, Educational Physical Therapy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Orofacial Myofunctional Disorders, Myo Munchee
Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).
Multi-center, 6-month, randomized, and controlled trial to compare the effects of Myo Munchee therapy and Oral Motor Therapy (OMT) in pediatric patients (aged 3-5 years) to treat maxillary deficiency and orofacial myofunctional…
- Conditions
- Orofacial Myofunctional Disorders, Myo Munchee, Oral Motor Therapy, Maxillary Deficiency
- Trial name
- NCT07088055
- Testing
- Chewing device only, Myo Munchee and Oral Motor Therapy Treatment, Oral Motor Therapy Treatment Arm
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Myo Munchee (Operations) Pty Ltd
Food Allergy, Loeys-Dietz Syndrome
Natural History and Genetics of Food Allergy and Related Conditions
Background: About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.
- Conditions
- Food Allergy, Loeys-Dietz Syndrome, Atopic Dermatitis, Eosinophilic Esophagitis
- Trial name
- NCT02504853
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)