Clinical trials: Cranial Neurosurgery, open to volunteers
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Cranial Neurosurgery
Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor
Transcranial focused ultrasound (tFUS) offers a platform for non-invasive imaging and treatment of the brain and pathology of the brain -- allowing high resolution imaging in both spatial and temporal dimensions.
- Trial name
- NCT05755399
- Testing
- Brain imaging using transcranial focused ultrasound (tFUS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Cranial Neurosurgery
A Study Of Subscalp Placement Of The LINQII Device
The purpose of this to evaluate the capability of the FDA approved Medtronic LINQ II device (implantable cardiac monitoring device) to record EEG signals when placed temporarily in the subscalp space in patients undergoing…
- Trial name
- NCT07752251
- Testing
- Medtronic LINQII
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Vestibular Schwannoma
3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular…
- Trial name
- NCT07844460
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shengjing Hospital
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Meningioma, Glioblastoma
Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures
This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of intracranial lesions.
- Conditions
- Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer
- Trial name
- NCT07493447
- Testing
- Panitumumab-IRDye800
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eben Rosenthal
Metopic Craniosynostosis, Craniosynostosis
Frontal Reconstruction Without Orbital Advancement for Moderate Metopic Craniosynostosis
Metopic craniosynostosis is a condition caused by the early fusion of the metopic suture, leading to restricted frontal bone growth and a triangular head deformity termed trigonocephaly.
- Conditions
- Metopic Craniosynostosis, Craniosynostosis, Metopic Synostosis
- Trial name
- NCT07837453
- Testing
- Frontal vault remodelling without orbital advancement
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Cranial Defects
Efficacy and Safety of 3D-Printed PEEK Skull Implants in Cranioplasty
The goal of this clinical trial is to determine the efficacy and safety of customized skull implants made of polyetheretheretherketone by three-dimensional printing in patients undergoing cranioplasty.
- Trial name
- NCT06782711
- Testing
- cranioplasty, customized skull implants made of polyetheretheretherketone (PEEK) using 3D printing
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- CIMET SCIENTIFIC CORPORATION
Brain Pathology
VR in Neurosurgery: Planning, Training & Communication
This prospective study analyzes the broad impact of virtual reality (VR) assistance on aneurysm surgeries through two primary focuses: first, it evaluates VR-assisted clip planning by examining its clinical outcomes in the…
- Trial name
- NCT06565234
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Wound Closure, Brain Tumor Adult
Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures
This research is studying a device already approved by the Food and Drug Administration (FDA) to treat wound closures. Researchers are studying a large group of people to continue to learn information about the safety of the…
- Conditions
- Wound Closure, Brain Tumor Adult, Spine, Neurovascular
- Trial name
- NCT07225101
- Testing
- STRATAFIX PDS and Monocryl suture
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Michigan
Neurosurgery, Surgical Planning
Real Time Craniotomy Planning Using Mixed Reality
This study is a prospective observational study designed to evaluate the effectiveness of Brainlab's Mixed Reality Viewer in enhancing the accuracy and efficiency of preoperative craniotomy planning.
- Conditions
- Neurosurgery, Surgical Planning, Brain Tumor Adult, Craniotomy Tumor Removal Surgery
- Trial name
- NCT07468370
- Testing
- Mixed Reality Glasses/Viewer, Survey using a questionnaire.
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brainlab AG
Brain Tumor Adult, Brain Tumor Benign
Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures
The purpose of this study is to compare two commonly used methods of closing the skin after surgery for an intracranial tumor. Skin closure is one of the most important steps in neurosurgical procedures, as it has a major…
- Conditions
- Brain Tumor Adult, Brain Tumor Benign, Meningioma, Glioma
- Trial name
- NEURO-SUTURE (NCT07413796)
- Testing
- Absorbable running intradermal suture, Non-absorbable interrupted transdermal suture
- Where
- Poland
- Volunteers
- 382 people
- Sponsor
- Medical University of Warsaw