Clinical trials: Coronary Vessel
Coronary Artery Disease
Effects of Guiding Catheter on FFR and NHPR for the Assessment of Coronary Artery Stenoses (Disengage@Rest)
The DISENGAGE@rest study is a prospective registry carried out at Federico II University of Naples with the aim to evaluate the influence of the guiding catheter engagement within the coronary ostium on both FFR and…
- Trial name
- Disengage@Rest (NCT04975425)
- Testing
- Fractional Flow Reserve
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Plaque, Atherosclerotic Disease
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
The BioImage Study is a study of the characteristics of subclinical cardiovascular disease, as measured by imaging modalities, unsupervised circulating biomarker measurements, and risk factors that predict progression to overt…
- Conditions
- Plaque, Atherosclerotic Disease, Heart Disease, Stroke
- Trial name
- NCT00738725
- Where
- 2 sites in United States
- Volunteers
- 7,687 people, healthy volunteers welcome
- Sponsor
- BG Medicine, Inc
Diabetes Mellitus, Coronary Artery Disease
Efficacy and Safety of Polymer-free Amphilimus-eluting Stent According to the Diabetes
Drug-eluting stents (DES) have been found to reduce the rate of stent restenosis compared to bare metal stents (BMS), but the first generation DES caused an increase in stent thrombosis.
- Trial name
- NCT05759676
- Testing
- Cre8™/Cre8™ EVO drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,800 people
- Sponsor
- Korea University Anam Hospital
LVAD, Frailty
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to…
- Conditions
- LVAD, Frailty, GI Bleed, Right Heart Failure
- Trial name
- NCT06039176
- Testing
- HeartMate 3 (R) left ventricular assist device
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- International Consortium of Circulatory Assist Clinicians
Coronary Artery Stenosis, Coronary Artery Disease
IRIS-Coroflex NEO Cohort
The objective of this study is to evaluate the effectiveness and safety of Coroflex ISAR NEO stents in comparison to other drug-eluting stents (DES) in real-world practice.
- Trial name
- IRIS Coroflex (NCT06177743)
- Testing
- Coroflex ISAR NEO stent
- Where
- 11 sites in South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seung-Jung Park
Depression, Coronary Heart Disease
Depression Outpatient Cardiology Screening Study
This study compares the effects of depression screening and case management to usual care in cardiology outpatients with documented evidence of coronary heart disease.
- Trial name
- DOCS (NCT01552889)
- Testing
- Collaborative Care
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease
Knowledge-based Iterative Model Reconstruction at Low-kilovoltage (kV) Cardiac Computed Tomography (CT)
The purpose of this study was to compare FBP-, hybrid IR-, and IMR techniques to assess their role in the identification of coronary artery disease and abnormalities in cardiac structures.
- Trial name
- NCT01896674
- Volunteers
- 21 people
- Sponsor
- Kumamoto University
Computed Tomography Angiography, Coronary Artery Disease
Techniques and Pitfalls of Multi-Slice CT Coronary Angiography
The goal of this study is to describe the techniques for coronary multi-slice CT angiography and to illustrate the spectrum of artifacts that can simulate coronary artery stenosis and lead to non-assessable segments using 128…
- Trial name
- NCT05729490
- Testing
- Coronary computed tomography angiography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Coronary Artery Disease
Multislice CT Angiography of Coronary Bifurcations and Outcomes After Intervention
This is prospective, observational study, that will be conducted in two high-volume university interventional cardiology centers.
- Trial name
- NCT01943643
- Testing
- multislice CT angiography
- Where
- Serbia
- Volunteers
- 70 people
- Sponsor
- Clinical Hospital Center Zemun
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Angina Pectoris
Evaluation of Graft Material in Coronary Artery Bypass Grafting (CABG)
The aim of the study is to evaluate the patency in different kinds of vessels used as graft material in coronary artery bypass grafting.
- Trial name
- NCT01310725
- Testing
- Coronary artery bypass grafting
- Where
- Sweden
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Coronary Artery Disease, Aortic Atherosclerotic Disease
Evaluation of the Strategy of "One-stop" Endovascular Treatment for Concomitant Coronary Artery Disease and Aortic Atherosclerotic Disease
The study is a prospective, randomized, controlled, exploratory trail to evaluate the strategy of "one-stop" endovascular treatment for concomitant coronary artery disease and aortic atherosclerotic disease.
- Trial name
- NCT03563768
- Testing
- One-stop strategy group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease, Coronary Artery Disease
Cardiovascular Evaluation Before Renal Transplantation
Due to rising importance of cardiovascular disease before and after renal transplantation we have changed our standard diagnostic procedure and perform stress echocardiography and myocardial scintigraphy.
- Trial name
- NCT01064674
- Testing
- diagnostic procedure
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Aortic Valve Stenosis, Postoperative Complications
Comparing Suture vs. Combined Closure Strategies for Large Blood Vessel Access in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)
The goal of this clinical trial is to compare two strategies for closing the main artery access site in adult patients undergoing transcatheter aortic valve implantation (TAVI) through a blood vessel in the leg (transfemoral…
- Conditions
- Aortic Valve Stenosis, Postoperative Complications, Vascular System Injuries, Hemorrhage
- Trial name
- SEAL-TAVI (NCT07743697)
- Testing
- Single Suture-Based Vascular Closure Device, Extravascular Collagen Plug-Based Closure Device
- Where
- Switzerland
- Volunteers
- 705 people
- Sponsor
- University Hospital, Basel, Switzerland
Hemorrhage, Gastrointestinal, Myocardial Infarction
A Study of Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications
The Purpose of this study is to examine whether evidence of channeling exists by analyzing within a cohort of participants with first prescriptions of single-ingredient paracetamol or ibuprofen (or both) whether participants with…
- Conditions
- Hemorrhage, Gastrointestinal, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- NCT02830178
- Where
- United States
- Volunteers
- 144,337 people
- Sponsor
- Janssen Research & Development, LLC
Atherosclerosis, Ischemic Heart Disease
Interleukin-4 (IL-4) as a Marker of Atherosclerosis
In recent years, medical research into the cause and progression of heart disease due to narrowing and blockage of blood vessels to the heart muscle has improved the understanding of ischemic heart disease.
- Trial name
- NCT00256035
- Testing
- Measuring IL-4 levels
- Sponsor
- Melbourne Health
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)
Many patients with non-ST-segment elevation myocardial infarction (NSTEMI) have multivessel coronary artery disease (MVD), which is associated with poor clinical outcomes.
- Conditions
- Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis, Multi Vessel Coronary Artery Disease
- Trial name
- NCT04968808
- Testing
- Staged in-hospital complete revascularization, Immediate complete revascularization
- Where
- South Korea
- Volunteers
- 1,014 people
- Sponsor
- Chonnam National University Hospital
Refractory Angina
Cardiac Rehabilitation in Patients With Refractory Angina
The purpose of this study is to evaluate the safety and feasibility of cardiovascular rehabilitation in Patients with refractory angina, evaluate the effect of cardiovascular rehabilitation in patients with angina Refractory, by…
- Trial name
- NCT03218891
- Testing
- Cardiac Rehabilitation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
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