Clinical trials: Coronary Vasospasm, open to volunteers
Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction
The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main…
- Trial name
- REDEFINE-CMD (NCT07337005)
- Testing
- Invasive coronary physiological measurements
- Volunteers
- 100 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Myocardial Infarction, Coronary Microvascular Dysfunction
Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and…
- Conditions
- Myocardial Infarction, Coronary Microvascular Dysfunction, Vasospasm, Coronary
- Trial name
- CMD-MINOCA (NCT05272618)
- Testing
- Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Chonnam National University Hospital
Coronary Spasm
Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm
The goal of this randomized clinical trial is to assess if adjunctive bosentan therapy, in comparison to placebo, can reduce the rate of epicardial vasospasm at follow-up spasm provocation CFT (fuCFT) in patients with previously…
- Trial name
- EDIT-CAS (NCT06432452)
- Testing
- Endothelin Receptor Antagonist
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Radial Artery Spasm, Radial Artery Access
The Effect of Using Virtual Reality Glasses on Anxiety-related Radial Vasospasm in Patients Undergoing Transradial Coronary Angiography
Compared to transfemoral access, transradial access is a safe and effective method for coronary interventions, associated with lower rates of vascular complications, including major bleeding.
- Conditions
- Radial Artery Spasm, Radial Artery Access, Virtual Reality
- Trial name
- NCT06726031
- Testing
- wearing VR glass
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mersin University
Coronary Microvascular Dysfunction, Coronary Artery Vasospasm
Belgian Registry on Coronary Function Testing
The goal of this prospective, multicenter registy is to describe the 'real-world' use of coronary function tests, which may consist of bolus thermodilution measurements of coronary microvascular function and/or invasive…
- Trial name
- BELmicro (NCT06089031)
- Testing
- Coronary Function Test
- Where
- 13 sites in Belgium
- Volunteers
- 650 people
- Sponsor
- University Hospital, Antwerp
Coronary Microvascular Disease, Coronary Vasospasm
Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition
The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.
- Trial name
- MICRO-SNAPE (NCT06125392)
- Testing
- Coronary physiology assessment
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht