Clinical trials: Coronary Microvascular Disease
Wiskott-Aldrich Syndrome, Thrombocytopenia
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
The purpose of this project is to describe the pathophysiology of thrombocytopenia and bleeding in patients with Wiskott-Aldrich Syndrome (WAS) and determine the response to thrombopoietic agents in vitro and in vivo.
- Conditions
- Wiskott-Aldrich Syndrome, Thrombocytopenia, Bleeding
- Trial name
- WAS (NCT00909363)
- Testing
- Promacta, blood drawing in patients with WAS, blood drawing in healthy controls
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Tinnitus, Metabolic Syndrome X
Lifestyle Changes in Older Adults With Metabolic Syndrome and Tinnitus
The problem of tinnitus (subjective type) is prevalent in obese older adults with different diseases such as metabolic syndrome. The changes of lifestyle are very important to lose weight, improve tinnitus and metabolic syndrome
- Conditions
- Tinnitus, Metabolic Syndrome X, Obesity, Elderly
- Trial name
- NCT06702085
- Testing
- Lifestyle Management
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cardiomyopathy, Hypertrophic, Coronary Disease
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart…
- Conditions
- Cardiomyopathy, Hypertrophic, Coronary Disease, Healthy, Myocardial Ischemia
- Trial name
- NCT00001459
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Microvascular Disease
Microvascular Disease Exercise Trial
For part of this study, we are collecting information from patients that have been experiencing the symptoms mentioned above. We are taking this information and creating a chest pain registry to follow trends and compare…
- Trial name
- MOVE (NCT02045459)
- Testing
- Exercise Program
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- University of Virginia
Anterior Myocardial Infarction
Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL
In this study we pretend to determine the molecular (miRNAs expression, angiogenic and inflammatory biomarkers) and microcirculatory (assessed by the innovative continuous intracoronary thermodilution technique) effects of PiCSO…
- Trial name
- PiCSO-STEMI (NCT05644925)
- Testing
- PiCSO Impulse System, Percutaneous Coronary Intervention (PCI)
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Coronary Microvascular Disease, CMD
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary…
- Trial name
- ExINOCA (NCT06529848)
- Testing
- Exercise training
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Metabolic Syndrome X, Insulin Resistance
Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia
Lipid abnormalities in people with the Metabolic Syndrome (the Insulin Resistance Syndrome) are characterized by elevations in triglycerides and LDL cholesterol; low levels of HDL cholesterol; and small, dense LDL particles.
- Trial name
- NCT00304993
- Testing
- fenofibrate, niacin, rosiglitazone
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Foundation Research, Florida
Cardiomyopathies, Microcirculation
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at…
- Conditions
- Cardiomyopathies, Microcirculation, Microvessels
- Trial name
- IMPAIRED (NCT02705170)
- Testing
- index of microvascular resistance
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Metabolic Syndrome X, Cardiovascular Problems in Elderly
Effect of Blood Flow Restriction on Cardiovascular Function in Elderly with Metabolic Syndrome X
The purpose of the study is to investigate the effect of aerobic exercise with Blood flow restriction training (BFR) on cardiovascular function and quality of life in hypertensive elderly patients.
- Trial name
- NCT06877130
- Testing
- Aerobic exercise with BFR, Aerobic training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2, Metabolic Syndrome X
A Phase IIa Proof-of-concept Study of NC-503 in Patients With Type II Diabetes
The main objectives of the current study are to establish the safety and clinical proof-of-concept of NC-503 in inadequately controlled patients with Type 2 diabetes and features of metabolic syndrome treated with either…
- Trial name
- NCT00675857
- Testing
- NC-503 (eprodisate disodium)
- Where
- 21 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Bellus Health Inc. - a GSK company
Metabolic Syndrome X
Effects of Tumor Necrosis Factor (TNF)-Alpha Antagonism in Patients With Metabolic Syndrome
Metabolic syndrome is associated with increased inflammatory cytokines and reduced adiponectin, that may be mediated in part by TNF production from abdominal fat.
- Trial name
- NCT00111956
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metabolic Syndrome X
The Effects of Omega-3 Fatty Acids on Metabolic Syndrome
The purpose of this study is to determine the effects of omega-3 fatty acids in the form of fish oil supplementation (approximately 2 grams per day) on the carotid intima-media (CIMT)progression (primary objective) and…
- Trial name
- NCT00350194
- Testing
- Omega-3 fatty acids
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Microvascular Angina
Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease
Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease
- Trial name
- NCT06076551
- Testing
- Adenosine stress echocardiography
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea University Anam Hospital
Metabolic Syndrome X
Environmental Triggers Of Cardiometabolic Disease
The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and India), are likely to provide new and much…
- Trial name
- AIRCMD (NCT01548300)
- Where
- 3 sites in United States, China
- Volunteers
- 66 people
- Sponsor
- Sanjay Rajagopalan
Peripheral Artery Disease, Coronary Disease
Evaluation of Patients With Known or Suspected Heart Disease
In this study researchers will admit and evaluate patients with known or suspected heart disease referred to the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).
- Conditions
- Peripheral Artery Disease, Coronary Disease, Diabetes and Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT00001313
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Sarcopenia
Diet and Exercise Interventions to Increase Muscle Strength and Function
The objective of this study is to test the effects of a healthy diet \& walking (Controls) compared to a healthy diet, walking, and balance/strength exercises (Intervention) on muscle density in two populations: elderly…
- Conditions
- Obesity, Sarcopenia, Metabolic Syndrome X
- Trial name
- NCT02850562
- Testing
- Walking, Walking + Exercise
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Multi Vessel Coronary Artery Disease, STEMI
Assessing Microvascular Resistance Via IMR To Predict Cumulative Outcome in STEMI Patients Undergoing Primary PCI
The purpose of this study is to assess whether the Index of Microcirculatory Resistance (IMR) can be considered a prognostic predictor for the occurrence of events at one year of follow up after primary Percutaneous Coronary…
- Trial name
- AMICRO (NCT02325973)
- Testing
- PressureWire Certus guidewire
- Where
- 14 sites in Italy
- Volunteers
- 242 people
- Sponsor
- Abbott Medical Devices