Clinical trials: Coronary Microvascular Disease
Coronary Microvascular Disease
Clinical Evaluation of Aromatic Wentong in the Treatment of Coronary Microvascular Disease
Coronary Microvascular Disease (CMD) is a condition where patients experience chest pain (angina) even though their coronary arteries appear normal on angiography.
- Trial name
- NCT06901570
- Testing
- Kuangxiong Aerosol
- Where
- China
- Volunteers
- 528 people
- Sponsor
- China-Japan Friendship Hospital
Coronary Microvascular Dysfunction, Ischaemia With Non Obstructed Coronary Arteries
Mechanisms Behind Microvascular Dysfunction in INOCA
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
- Trial name
- ExINOCA-P1 (NCT06529861)
- Testing
- [15O]H2O-PET Imaging
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Coronary Microvascular Dysfunction, Cardiotoxicity
Effects of Immune Checkpoint Inhibitors on Coronary Microvasculature
This is an observational study that includes patients with breast cancer or non-small cell lung cancer who will be treated with immune checkpoint inhibitor (ICI) therapy.
- Conditions
- Coronary Microvascular Dysfunction, Cardiotoxicity, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- NCT06332131
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Coronary Microvascular Disease
An Observational Study of Coronary Microvascular Disease of China
Non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels.
- Trial name
- CCMD (NCT06676137)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Simultaneous Assessment of Coronary Microvascular Dysfunction and Ischemia With Non-obstructed Coronary Arteries With Intracoronary Electrocardiogram and Intracoronary Doppler
Coronary Microvascular Dysfunction has been consistently shown to play a considerable role in pathophysiology of Ischaemia with non-obstructed coronary arteries (INOCA).
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Non-Obstructive Coronary Atherosclerosis, Microvascular Angina
- Trial name
- NCT05471739
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Istanbul University
Prediabetic State, Metabolic Syndrome X
Culturally-adapted Diabetes Prevention Lifestyle Intervention for Latinos (E-LITE Latinos)
The purpose of the study is to develop a culturally adapted intervention (CAI) program to improve weight and physical activity in overweight or obese adult Latinos at high risk for developing type 2 diabetes and/or cardiovascular…
- Conditions
- Prediabetic State, Metabolic Syndrome X, Insulin Resistance
- Trial name
- NCT02459691
- Testing
- Vida Sana, Usual Care Only
- Volunteers
- 191 people
- Sponsor
- Palo Alto Medical Foundation
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness
Cilostazol is an antiplatelet agent used to reduce the symptoms of intermittent claudication. Cilostazol inhibits phosphodiesterase III (PDE III), which causes it to be a vasodilator and inhibitor of platelet aggregation.
- Trial name
- NCT00573950
- Testing
- cilostazol
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Korea University Anam Hospital
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Self-Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD) (SERRA-I Study)
VahatiCor's Coronary Sinus Reducer (A-FLUX) has been designed to improve angina or angina-like symptoms in patients with CMD. SERRA-I is an early feasibility study that evaluates the safety and clinical performance of the A-FLUX…
- Trial name
- NCT06991322
- Testing
- A-FLUX Reducer System
- Where
- 3 sites in Netherlands, Poland and 1 more
- Volunteers
- 30 people
- Sponsor
- VahatiCor, Inc.
Coronary Microvascular Perfusion in Patients With Ischemic Heart Disease
PGE1 Improves Coronary Microcirculation Dysfunction in Patients With CAD and Diabetes
This study is undertaken to determine if intravenous Lipo-PGE1 therapy would improve coronary microvascular perfusion in patients with ischemic heart disease by CMRI.
- Trial name
- NCT03159559
- Testing
- Lipo-PGE1
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Myocardial Ischemia
Comparative Study of Magnetocardiography and Emission Computed Tomography.
Coronary atherosclerotic heart disease (CHD) and Coronary Microvascular Disease (CMVD), as the primary etiologies of myocardial ischemia, have garnered increasing clinical attention due to their high prevalence and severe…
- Trial name
- NCT07078266
- Testing
- Magnetocardiography examination
- Volunteers
- 218 people
- Sponsor
- Yang Jing
Myocardial Ischemia
Microvascular Coronary Disease In Women: Impact Of Ranolazine
1. To evaluate the impact of ranolazine extended-release tablets in women with subendocardial ischemia due to microvascular endothelial dysfunction on myocardial ischemia (Cardiac Magnetic Resonance (CMR) extent, severity. 2.
- Trial name
- NCT00570089
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Congenital Heart Disease
International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease
The international multicenter registry aims to collect real-world data on clinical outcomes and evaluate the net clinical success of transcatheter microvascular plug (MVP)-based pulmonary flow restrictors (PFRs) in patients with…
- Trial name
- RESTRICT (NCT07791069)
- Testing
- Transcatheter pulmonary flow restriction
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Hypertension, Metabolic Syndrome X
Clinical EvaluatioN of TElmisartan-based Antihypertensive Regimen
To determine the efficacy and safety of telmisartan-based treatment among patients with metabolic syndrome in actual setting in Philippines.
- Trial name
- NCT00613314
- Where
- 122 sites in Philippines
- Volunteers
- 15,268 people
- Sponsor
- Boehringer Ingelheim
Psoriasis, Cardiovascular Disease
MIcrovascular dysfuNction In Moderate-severe Psoriasis
Psoriasis, a common chronic inflammatory skin disease affecting approximately 2% of the population, is associated with increased cardiovascular (CV) risk.
- Trial name
- MINIMA (NCT04271540)
- Testing
- Tildrakizumab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Marcelo F. Di Carli, MD, FACC
Heart Failure, Congestive
MR, Myocardial Infarct and Heart Failure
KoMPiS is a contrast aided cardiac magnetic resonance study of microvascular obstruction and left ventricular remodelling following acute revascularised anterior myocardial infarction.
- Trial name
- KoMPiS (NCT00465868)
- Testing
- PCI (percutaneous coronary intervention)
- Where
- Norway
- Volunteers
- 44 people
- Sponsor
- Helse Stavanger HF
Sickle Cell Disease
Microvessels and Heart Problems in Sickle Cell Disease
Background: Small blood vessels (microvessels) in many different organs are affected by diseases such as diabetes and atherosclerosis. These microvessels may also be abnormal in people who have sickle cell disease.
- Trial name
- NCT01602809
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Stenosis
Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI
The Physiological Study of Haemodynamic and Microcirculatory Evolution before/after Transcatheter Aortic Valve Replacement (TAVI) aims to investigate the physiological changes induced by the implantation of a prosthetic aortic…
- Trial name
- TAVI (NCT06154642)
- Testing
- Determination of arterial compliance using blood pressure waveform analysis, Measurement of plasma Vascular Endothelium Growth Factor, Skin temperature gradient
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Geneva
Metabolic Syndrome X
OPUS School Meal Study
The aim of this randomized crossover study, is to investigate the effect of school meals based on a sustainable New Nordic Diet on growth, learning abilities, well-being, sleep quality, physical activity and risk markers of…
- Trial name
- NCT01457794
- Testing
- School meals based on the principles of the New Nordic Diet
- Where
- Denmark
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- Arne Astrup
Chronic Coronary Syndrome, Coronary Artery Disease
Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
AID-ANGIO is an observational, prospective, single arm, longitudinal study. Its objective is to investigate the diagnostic yield of the systematic use of a diagnostic strategy hierarchically addressing both obstructive and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Microvascular Angina, Coronary Vasospasm
- Trial name
- AID-ANGIO (NCT05635994)
- Testing
- AID strategy
- Where
- 4 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Hospital San Carlos, Madrid