Clinical trials: Coronary Circulation
Coronary Artery Disease
Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery
This observational prospective clinical study is to develop software tools to fuse coronary anatomy data obtained from CT coronary angiography with dynamic PET data to noninvasively measure absolute myocardial blood flow, flow…
- Trial name
- NCT04221594
- Testing
- Invasive Cardiac Catheterization (ICA), Coronary Computed Tomographic Angiogram (CCTA), Dynamic Cardiac Positron Emission Tomography (dPET)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 68 people
- Sponsor
- Emory University
Hypoperfusion in Newborn With Congenital Heart Disease
Cerebral Blood Flow in Neonates During Major Cardiac Surgery.
Rationale: During cardiac surgery, neonates are at high risk of cerebral damage: 36-78% will have new cerebral lesions after surgery.
- Trial name
- FLOWER (NCT04713605)
- Testing
- Critical closing pressure detection
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Cardiogenic Shock
Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock
The efficacy and tolerability of norepinephrine and epinephrine in cardiogenic shock after reperfused myocardial infarction will be compared, by following cardiac index evolution as main criteria.
- Trial name
- OptimaCC (NCT01367743)
- Testing
- epinephrine perfusion, norepinephrine perfusion
- Where
- 11 sites in France
- Volunteers
- 58 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease
Comparing Blood Loss, RBC Transfusions and Inflammatory Marker Changes Among Methods of CPB
The purpose of this study is to compare blood loss and the number of transfusions received by each patient having coronary bypass surgery.
- Trial name
- NCT01083914
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Baylor Research Institute
Peripheral Collaterals, Arteriogenesis
Assessment of Natural Bypasses in the Lower Limb
Concerning the promotion of peripheral collateral growth, clinical studies investigating new therapeutic strategies have used imprecise assessment methods and therefore determined only "weak" endpoints.
- Conditions
- Peripheral Collaterals, Arteriogenesis, Coronary Artery Disease
- Trial name
- NCT01742455
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Death, Sudden, Cardiac, Perfusion Index
Is the Perfusion Index an Accurate Predictor of Return of Spontaneus Circulation in Out-of-hospital Cardiac Arrest
The purpose of this pilot feasibility study is to evaluate the ability of the Perfusion Index to predict the return to spontaneous circulation of the out-of-hospital cardiac arrest patient during cardiopulmonary resuscitation.
- Conditions
- Death, Sudden, Cardiac, Perfusion Index, Return of Spontaneous Circulation
- Trial name
- NCT05383885
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure，Congestive
Effect of mechanIcal circulatoRy Support ON Exercise Capacity aMong pAtieNts With Heart Failure
This study will evaluate how the cardiovascular system interacts with mechanical hearts to provide blood flow to the body during exercise.
- Trial name
- IRONMAN (NCT03078972)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Atrial Septal Defect
The Effect of the Hole in the Cardiac Septum Developed by the MitraClip Procedure on the Blood Flow Mechanics
Patients received a MitraClip procedure because of a leakiness of their mitral valves. During this procedure the atrioventricular valves were stuck together permanently via a clip which leads to a reduction of leakiness.
- Trial name
- MitraClipASD (NCT02453451)
- Testing
- 2D-/3D-TTE, 3D-TEE, Walking Test
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Chronic Heart Failure, Hyperuricemia
Allopurinol in Chronic Heart Failure
The purpose of this study is to discover whether the inhibition of the xanthine oxidase with allopurinol leads to a reduction of the production of oxygen free radicals in patients with CHF and thereby improves characteristics of…
- Trial name
- NCT00997542
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- National Heart and Lung Institute
Acute Myocardial Infarction
Transcutaneous Electrical Nerve Stimulation Improves Vascular Conductance After Coronary Artery Bypass Graft Surgery
The investigators will test the hypothesis that transcutaneous electrical nerve stimulation (TENS) may attenuate peripheral vasoconstriction and to improve blood flow redistribution during handgrip exercise in acute myocardial…
- Trial name
- TEBCABG (NCT01777659)
- Testing
- Transcutaneous electrical nerve stimulation
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure
Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure
A Prospective Observational, Multi-Center, Real-World Pharmacological Study Evaluating Adherence to Guideline-Directed Medical Therapy Using the Four-Pillar Strategy in Patients with Advanced Heart Failure
- Trial name
- ad-HUB (NCT07560982)
- Testing
- GDMT, Quality of life questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Fontan Circulation
Fontan Circulation and Reproductive Health in a National Swedish Cohort
In the Swedish registry for congenital heart defects, SWEDCON, over 230 patients with single-ventricle circulation are registered in the adult section.
- Trial name
- NCT06258382
- Testing
- Questionnaires and functional test
- Where
- 15 sites in Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Caroline Lilliecreutz
Fractional Flow Reserve, Absolute Flow Measurement
Myocardial Mass Determination by FFRct and Absolute Coronary Blood Flow
The background for performing the present study is to compare the mass calculations by CT scanning and by invasive absolute blood flow measurements and thereby corroborating both methods.
- Conditions
- Fractional Flow Reserve, Absolute Flow Measurement, FFR-CT, Myocardial Mass
- Trial name
- MyoMass (NCT03393871)
- Testing
- absolute blood flow measurement
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Acute Cardiogenic Shock
Transient Circulatory Support in Cardiogenic Shock
The purpose of this multicenter prospective study is to determine if the decision of transient circulatory support (TCS) in cardiogenic shock is relevant.
- Trial name
- ALLOASSIST (NCT03528291)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Montpellier
Cardiacsurgery
Monitoring of Cerebral Blood Flow Autoregulation Using Near Infrared Spectroscopy
Blood flow to the brain is normally regulated to ensure a constant supply of blood with oxygen and nutrients. During heart surgery using cardiopulmonary bypass, blood pressure is kept at a level that may or may not be below an…
- Trial name
- NCT00769691
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Johns Hopkins University
Stable Coronary Artery Disease
Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD
Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.
- Trial name
- NCT01209637
- Testing
- exercise training, Intensive exercise training
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Magnetic Resonance Imaging, Tetralogy of Fallot
4D Velocity Mapping of the Heart in rTOF Patients
MRI with 4D flow permits to assess the hemodynamic parameters in a parent vessel and its branches inside the same sequence.
- Trial name
- CARDIOFLUX (NCT02980614)
- Testing
- 4D flow imaging
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease
3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.
- Conditions
- Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease, Cardiac Risk Factors, Myocardial Infarction
- Trial name
- NCT05286593
- Testing
- Slow Infusion of Rubidium-82
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Heart Failure
Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.
- Trial name
- NCT00924014
- Testing
- Conivaptan, Furosemide, Conivaptan and furosemide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hennepin County Medical Center, Minneapolis