Clinical trials: Coronary Circulation
Cardiac Surgery, Extracorporeal Circulation
Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome
Observational, prospective, monocentric study conducted in the cardiac surgery department about biological markers to predict the short-term outcome of heart surgery patients.
- Trial name
- VARIOXY (NCT06840327)
- Testing
- Blood and tissue samples, walking test
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Failure of Fontan Type Circulation, Fenestration
Occlutech AFR Fontan Study
The goal of this observational clinical study look at the safety and effectiveness of the Occlutech Atrial Flow Regulator in the treatment of patients with failing Fontan circulation.
- Conditions
- Failure of Fontan Type Circulation, Fenestration, Univentricular Heart, Congenital Anomaly
- Trial name
- NCT07532369
- Testing
- Occlutech Atrial Flow Regulator Retrospective Data Collection
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Occlutech International AB
Cardiac Arrest, Sudden Death
A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest (APACAR2)
Cardiac arrest (CA) affects approximately 40,000 people in France. It is still a major cause of death in a young population. Management of CA is defined by international recommendations, detailed by learned societies in each…
- Trial name
- APACAR2 (NCT02527031)
- Testing
- ECMO Insertion on pre hospital setting, In Hospital ECMO
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Seizures
Neural Circulatory Control and SUDEP Risk.
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP).
- Trial name
- NC-SUDEP (NCT02813980)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Extracorporeal Circulation, Hemofiltration
Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB
In a lot of cases during cardiac surgery cardiopulmonary bypass initiates SIRS due to release of cytokines during immunological response. They are induced by different types of inductors ( intrinsic and extrinsic).
- Trial name
- REMOTE (NCT03104179)
- Testing
- Cytosorb Adsorber
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Klinikum Nürnberg
Circulatory Shock, Sepsis
Shock and Acute Conditions OutcOmes Platform
In-hospital mortality of patients admitted in the intensive care unit (ICU) for circulatory shock remains high (between 20 and 40%).
- Conditions
- Circulatory Shock, Sepsis, Cardiogenic Shock, Major Trauma
- Trial name
- ShockCO-OP (NCT06376318)
- Testing
- Inotrope, Mechanical circulatory support, anti-bodies
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Heart Failure; With Decompensation, Cardiorenal Syndrome
The Aortix CRS Pilot Study
The Aortix CRS Pilot Study: An Evaluation of the Safety and Performance of the Aortix System for Intra-Aortic Mechanical Circulatory Support in Patients with Cardiorenal Syndrome
- Conditions
- Heart Failure; With Decompensation, Cardiorenal Syndrome, Cardio-Renal Syndrome, Heart Failure
- Trial name
- NCT04145635
- Testing
- Aortix System
- Where
- 19 sites in United States, Australia
- Volunteers
- 21 people
- Sponsor
- Procyrion
Cardiacsurgery
Monitoring of Cerebral Blood Flow Autoregulation Using Near Infrared Spectroscopy
Blood flow to the brain is normally regulated to ensure a constant supply of blood with oxygen and nutrients. During heart surgery using cardiopulmonary bypass, blood pressure is kept at a level that may or may not be below an…
- Trial name
- NCT00769691
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Johns Hopkins University
Cardiogenic Shock
Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock
The efficacy and tolerability of norepinephrine and epinephrine in cardiogenic shock after reperfused myocardial infarction will be compared, by following cardiac index evolution as main criteria.
- Trial name
- OptimaCC (NCT01367743)
- Testing
- epinephrine perfusion, norepinephrine perfusion
- Where
- 11 sites in France
- Volunteers
- 58 people
- Sponsor
- Central Hospital, Nancy, France
Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease
3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.
- Conditions
- Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease, Cardiac Risk Factors, Myocardial Infarction
- Trial name
- NCT05286593
- Testing
- Slow Infusion of Rubidium-82
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Coronary Artery Disease
Multi-center Trial of SPECT Myocardial Blood Flow Quantitation for Detection of Coronary Artery Disease
Patients with suspected or known coronary artery disease who are scheduled for clinically indicated SPECT myocardial perfusion imaging (MPI) and will receive invasive coronary angiogram are recruited to receive SPECT MBF study.
- Trial name
- NCT03637725
- Where
- 4 sites in China
- Volunteers
- 221 people
- Sponsor
- China National Center for Cardiovascular Diseases
Non-Obstructive Coronary Atherosclerosis
Effect of Mental Stress on Myocardial Perfusion in Women
Mental stress-induced myocardial ischemia(MSIMI) has been recognized a significant clinical problem. Evidence has shown that individuals with MSIMI have 2 to 2.5 times higher risk to develop a major averse cardiovascular events…
- Trial name
- MS in women (NCT03982901)
- Testing
- Mental Stress Test
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Butylphthalide, Cardiac Arrest
Neuroprotective Effect of Butylphthalide for Cardiac Arrest Patients
Cardiac arrest is one of the critical illnesses that is directly life-threatening, and patients who survive cardiac arrest develop severe neurological deficits or even die.
- Conditions
- Butylphthalide, Cardiac Arrest, Neuroprotective Drugs
- Trial name
- NCT06572085
- Testing
- Butylphthalide and Sodium Chloride Injection, Saline Solution
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tang Ziren
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Clinical Efficacy of Permanent Internal Mammary Artery Occlusion in Stable Coronary Artery Disease
Cardiovascular diseases remain the number one cause of death globally, primarily consequence of myocardial infarction. Although widely used in stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) has not…
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Ischemia, Circulation, Collateral
- Trial name
- NCT03710070
- Testing
- Amplatzer vascular plug 4
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Health, Subjective
Effects of Blood Flow Restriction Training on Exercises in Healthy Individuals.
Partial restriction of blood flow to working muscles during exercise is proven to increase muscle mass and strength even with low-intensity of exercise.
- Trial name
- NCT06254586
- Testing
- Aerobic exercises, Resisted exercises
- Where
- Saudi Arabia
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Organ Transplant
DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors
The purpose the research is to evaluate whether patients who receive a Donation after Circulatory Death (DCD) heart for cardiac transplantation using either normothermic regional perfusion (NRP) or direct procurement and…
- Trial name
- NCT05462041
- Testing
- DBD Donor Heart Transplantation, DCD Donor Heart Transplantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Type 2 Diabetes Mellitus
Endothelial and Metabolic Effects of Glucagon-like Peptide-1 (GLP-1) in Coronary Circulation in Patients With Type 2 Diabetes Mellitus
GLP-1 is an incretin hormone which is discharged from the intestines after food intake. The hormone is known for its powerful insulinotropic and trophic effects on the beta cells in the pancreas and is currently used as an…
- Trial name
- NCT00923962
- Testing
- Glucagon like peptide-1, Adenosine
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Heart Failure, Circulatory Disorders Postprocedural Complication
Observational Hemodynamic Monitoring During LVAD Implantation Among Individuals With Advanced Heart Failure
The overall objective of this pilot analysis is to characterize the hemodynamic changes that occur during implantation of a left ventricular assist device (LVAD) in patients with advanced heart failure - specifically, how right…
- Conditions
- Heart Failure, Circulatory Disorders Postprocedural Complication, Cardiomyopathy, Congestive, Surgery
- Trial name
- BATMAN (NCT03464981)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver