Clinical trials: Coronary Artery Bypass Graft Surgery
Coronary Artery Disease, Acute Cerebrovascular Accident
Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit
The prospective, randomized, two centre study investigates acute cerebrovascular events during extracorporal circulation and the early post operative outcome when using either the minimized cardiopulmonary bypass circuit…
- Conditions
- Coronary Artery Disease, Acute Cerebrovascular Accident, Intracranial Embolism, Embolism, Air
- Trial name
- ROCsafeTM (NCT00862160)
- Testing
- ROCsafeTM
- Where
- 2 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Hannover Medical School
Heart Disease, Cardiovascular Disease
Best Bypass Surgery (BBS) Trial
There is evidence linking cardiopulmonary bypass to negative side effects when used for coronary artery bypass grafting. Coronary artery bypass grafting can be performed without the use of cardiopulmonary bypass.
- Trial name
- NCT00120991
- Testing
- Coronary artery bypass grafting
- Where
- Denmark
- Volunteers
- 341 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Arrhythmias, Cardiac
Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter
The purpose of this study is to determine whether a strategy of maintaining serum potassium levels at ≥3.6 mEq/L is non-inferior to a strategy of usual treatment (≥4.5 mEq/L) on the occurrence of new onset atrial fibrillation…
- Trial name
- TIGHT-K (NCT04053816)
- Testing
- Potassium
- Where
- United Kingdom
- Volunteers
- 1,684 people
- Sponsor
- Barts & The London NHS Trust
Postoperative Hemorrhage
Hetastarch and Bleeding Complications After Off-Pump Coronary Bypass Surgery
There has been continuing debate about whether use of hetastarch for volume replacement in coronary artery bypass surgery [CABG] increases the risk of postoperative bleeding.
- Trial name
- NCT00307138
- Testing
- hetastarch
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Kaiser Permanente
Coronary Artery Bypass, Anesthesia, Conduction
Effect of Transversus Thoracic Muscle Plane Block (TTMP) on Analgesia
In this prospective and controlled study, the investigators investigated the effect of transversus thoracic muscle plane block (TTMP) on analgesia in patients who undergo coronary artery bypass graft (CABG) surgery with median…
- Conditions
- Coronary Artery Bypass, Anesthesia, Conduction, Nerve Block, Pain, Postoperative
- Trial name
- NCT06601530
- Testing
- Transversus Thoracic Muscle Plane Block, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University - Cerrahpasa
Myocardial Injury
Remote Ischemic Preconditioning in Coronary Artery Bypass Grafting With Cold Crystalloid Cardioplegic Arrest
Remote ischemic preconditioning (RIPC) with transient upper limb ischemia/reperfusion reduces myocardial injury in patients undergoing on-pump coronary artery bypass (CABG) surgery with cross-clamp fibrillation or blood…
- Trial name
- NCT01406678
- Testing
- RIPC, Control, isoflurane+sufentanil anesthesia
- Where
- Germany
- Volunteers
- 1,204 people
- Sponsor
- University Hospital, Essen
Postoperative Pain, Regional Anaesthsia
Parasternal and Adductor Canal Blocks in CABG
This randomized controlled trial evaluates the effectiveness of different postoperative analgesic strategies in patients undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Postoperative Pain, Regional Anaesthsia, Pain Management
- Trial name
- NCT07599748
- Testing
- parasternal block, Parasternal block + Adductor canal block, conventional analgesic regimen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Zonguldak Bulent Ecevit University
Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation
Once Versus Twice Bisoprolol Dosage Regimen in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft Surgery
The goal of this interventional clinical trial is compare between two different dose regimens of bisoprolol (beta-blocker) in CABG patients in terms of efficacy and safety.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation, Coronary Artery Disease
- Trial name
- NCT05730413
- Testing
- Bisoprolol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Coronary Artery Disease, Postoperative Pain
Five Multimodal AI Configurations Versus Expert Anaesthesiologists for Classifying Pecto-Intercostal Fascial Plane Block Spread in CABG
This prospective observational cohort with a nested archived-image reader study compared the sonographic pecto-intercostal fascial plane block classifications of five general-purpose multimodal artificial-intelligence…
- Trial name
- NCT07581678
- Testing
- Pecto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Artery Bypass Graft Surgery Patients
Improving Outcomes and Quality of Life After CABG
The principal objective to this randomized trial is to compare the efficacy of two strategies of intra-operative hemodynamic management during cardiopulmonary bypass among patients undergoing primary elective coronary artery…
- Trial name
- NCT00256620
- Testing
- Mean arterial pressure during cardiopulmonary bypass 80 mmHg vs. customized
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Weill Medical College of Cornell University
Ischemic Heart Disease
Saline Bag and TEE During Cardiac Displacement
During cardiac displacement for off-pump coronary artery bypass(OPCAB) surgery, the presence of air underneath the displaced heart compromises the transgastric (TG) window for transoesophageal echocardiography(TOE).
- Trial name
- NCT01616979
- Testing
- placing saline bag during cardiac displacement
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease, Atherosclerosis
Radial Artery Patency and Clinical Outcomes Trial
Coronary Artery Bypass Graft (CABG)Surgery is commonly used to treat patients with coronary artery disease (atherosclerosis) for the relief of angina (chest pain) and improve heart muscle function.
- Trial name
- RAPCO (NCT00475488)
- Testing
- Coronary artery bypass grafting
- Where
- Australia
- Volunteers
- 605 people
- Sponsor
- Austin Health
Cardiovascular Diseases, Coronary Artery Disease
The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia
The goal of this study is to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Hypoxia
- Trial name
- VENTMICS-II (NCT05417217)
- Testing
- Discontinued ventilation, Continued ventilation
- Where
- Belgium
- Volunteers
- 165 people
- Sponsor
- Jessa Hospital
Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG)
Mechanical Power and Pulmonary Complications in CABG Surgery
This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative…
- Conditions
- Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG), Prolonged Mechanical Ventilation
- Trial name
- MP-CABG (NCT07639489)
- Testing
- Intraoperative Mechanical Ventilation Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fusun Gozen
Coronary Artery Disease
Collagen-thrombin Matrix Efficacy During Cardiac Surgery: a Prospective Randomized Controlled Trial
In this prospective open-label randomized trial, 160 patients with elective off-pump coronary artery bypass (OPCAB) surgery were enrolled.
- Trial name
- NCT04310150
- Testing
- Collastat, Floseal
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
CHD - Coronary Heart Disease
Assessment of the Usefulness of Hemopatch in Coronary Artery Bypass Graft Surgery
The study aim is to assess polyethylene glycol (PEG) coated collagen patch (Hemopatch) on the quality of drainage after surgery, the length of hospital stay, the number of reoperations due to haemorrhage and treatment cost.
- Trial name
- Hemopatch (NCT03340090)
- Testing
- Medical Device Hemopatch-PEG-coated collagen patch
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Lodz
Coronary Artery Disease, Surgery--Complications
Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery
This is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. Prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill.
- Trial name
- NCT03376542
- Testing
- Cardiopulmonary Exercise Testing
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Eduardo Tibirica, MD, PhD
Coronary Artery Bypass Grafting, Mitral Valve Surgery
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass
A study to evaluate levosimendan compared with placebo in reducing the composite event rate of all-cause death, perioperative MI, need for new dialysis, or use of mechanical assist (IABP, LVAD or ECMO) in subjects with reduced…
- Conditions
- Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
- Trial name
- LEVO-CTS (NCT02025621)
- Testing
- Levosimendan
- Where
- 60 sites in United States, Canada
- Volunteers
- 882 people
- Sponsor
- Tenax Therapeutics, Inc.
Coronary Artery Disease
Desflurane Versus Propofol Anesthesia for Off-Pump CABG
The purpose of this study is to prove if anesthesia maintained with the inhaled volatile anesthetic desflurane is superior to the intravenously applied propofol anesthesia in off-pump coronary artery bypass grafting (OP-CABG)…
- Trial name
- NCT00528515
- Testing
- Diprivan (propofol), Astra-Zeneca, Suprane (desflurane), Baxter
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Angina Pectoris
Vein vs Arterial Grafts for Coronary Artery Bypass Grafting Surgery
The investigators have developed a novel technique for saphenous vein graft harvesting for coronary artery bypass grafting (CABG) where the graft is harvested with a pedicle of surrounding tissue.
- Trial name
- NCT02158455
- Testing
- NT SVG grafts
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Region Örebro County