Clinical trials: Corneal Transplantation
Corneal Transplantation, Graft Rejection
Collaborative Corneal Transplantation Studies (CCTS)
To determine whether histocompatibility matching of corneal transplant donors and recipients can reduce the incidence of graft rejection in high-risk patients.
- Trial name
- NCT00000137
- Testing
- Histocompatibility Matching
- Sponsor
- National Eye Institute (NEI)
Corneal Transplantation
Comparison of DCT, ORA and GAT in Eyes After Penetrating Keratoplasty
To compare intraocular pressure (IOP) measured by the Reichert Ocular Response Analyzer (ORA), Pascal dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT) in eyes after Penetrating Keratoplasty (KPL)
- Trial name
- NCT00834782
- Testing
- IOP measurement
- Where
- 2 sites in Israel
- Volunteers
- 35 people
- Sponsor
- Sheba Medical Center
Corneal Transplantation
Ocular Penetration of 1.5% Levofloxacin and 0.5% Moxifloxacin During Corneal Transplant Surgery
Compare the corneal penetration of levofloxacin 1.5% and moxifloxacin 0.5% in patients undergoing penetrating keratoplasty (PK)
- Trial name
- NCT00764582
- Testing
- 1.5% levofloxacin ophthalmic solution, 0.5% moxifloxacin ophthalmic solution
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Santen Inc.
Corneal Transplantation
A Prospective Study of the Effect of Topical Sodium Hyaluronate Immediately Post-PKP on Time to Reepithelialization
Hypothesis: 1% sodium hyaluronate (Healon), applied at end of surgery to the surface of a corneal transplant will not shorten graft reepithelialization time when compared to coating with nothing.
- Trial name
- NCT00570648
- Testing
- sodium hyaluronate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Corneal Transplantation
A Prospective Randomized Trial on Mycophenolate Mofetil in Risk Penetrating Keratoplasty
The purpose of this prospectively randomized multicentre study was to prove the efficacy and safety of mycophenolate mofetil (MMF) to preventing graft rejection and improvement of clear graft survival following high-risk…
- Trial name
- NCT00411515
- Testing
- Mycophenolate Mofetil 2x 1g
- Where
- Germany
- Sponsor
- University Hospital Freiburg
Corneal Transplantation
Prospective, Randomized Trial of Basiliximab (Simulect) in the Prophylaxis of High-Risk Keratoplasty Patients
Most high risk keratoplasties are currently performed under systemic immunosuppression. Immunosuppressants are currently either Cyclosporine A or mycophenolate mofetile, administered for around 6 months.
- Trial name
- NCT00409656
- Testing
- Basiliximab
- Sponsor
- University Hospital Freiburg