Clinical trials: Corneal Edema
Corneal Edema, Fuchs
Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells [mHCECs]), compared with a placebo injection, in…
- Conditions
- Corneal Edema, Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- EMERALD (NCT07729137)
- Testing
- 150K cells, 500K cells
- Where
- 10 sites in United States
- Volunteers
- 121 people
- Sponsor
- Emmecell
Corneal Edema, Corneal Endothelial Dysfunction
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK)
- Trial name
- NCT07368959
- Testing
- Combination Product: AURN001 + Y-27632
- Where
- 12 sites in United States
- Volunteers
- 130 people
- Sponsor
- Aurion Biotech
Corneal Edema After Cataract Surgery
A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery
The purpose of this study is to assess the safety and efficacy of K-321 in subjects after cataract surgery
- Trial name
- NCT05528172
- Testing
- Ripasudil
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 330 people
- Sponsor
- Kowa Research Institute, Inc.
Corneal Edema
EndoArt® Implantation in Subjects With Chronic Corneal Edema - US Study
The EndoArt® device is intended to treat patients with chronic corneal edema due to endothelial dysfunction, in whom prior multiple keratoplasty (EK/PK) have failed, and who are not reasonable candidates for any form of corneal…
- Trial name
- NCT07344168
- Testing
- The EndoArt® (Corneal Artificial Endothelial layer)
- Volunteers
- 123 people
- Sponsor
- Eye-yon Medical
Corneal Edema, Fuchs' Endothelial Dystrophy
PVEK Corneal Implant For Treatment of Corneal Edema
The goal of this clinical trial is to learn if PVEK, a corneal implant , is safe and well tolerated for people with corneal swelling caused by Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy who need endothelial…
- Conditions
- Corneal Edema, Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Corneal Endothelial Dysfunction
- Trial name
- CIFRE (NCT07325097)
- Testing
- Precise Vision Endothelial Keratoplasty (PVEK) Implant
- Where
- 3 sites in Armenia, Israel
- Volunteers
- 15 people
- Sponsor
- Precise Bio
Corneal Edema, Corneal Endothelial Dysfunction
A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)
The goal of this clinical trial is to compare different doses of AURN001 in patients with corneal edema secondary to corneal endothelial dysfunction.
- Trial name
- CLARA (NCT06041256)
- Testing
- AURN001, Corneal Endothelial Cells, Y27632
- Where
- 20 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Aurion Biotech
Corneal Edema, Corneal Endothelial Dysfunction
Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema
Corneal edema is the most common indication for corneal transplantation, accounting for approximately 70% of penetrating keratoplasty (PK), and 100% of endothelial keratoplasty (EK) procedures annually.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Corneal Endothelial Dystrophy, Fuchs Dystrophy
- Trial name
- NCT04894110
- Testing
- EO2002, EO2002 low dose, EO2002 mid dose
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- Emmecell
Corneal Edema
Study of Cryopreserved AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the safety and efficacy of cryopreserved AURN001 in patients with corneal edema secondary to endothelial dysfunction.
- Trial name
- NCT06630169
- Testing
- Cryopreserved AURN001
- Where
- El Salvador
- Volunteers
- 25 people
- Sponsor
- Aurion Biotech
Bullous Keratopathy, Corneal Erosion
Air Optix® Night and Day® Aqua Therapeutic Wear
The purpose of this study is to support the safety and performance assessment of Air Optix Night and Day Aqua (AONDA) soft contact lenses for therapeutic use in accordance with updated EU Medical Device Regulation (MDR)…
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05956535
- Testing
- Lotrafilcon A contact lenses, Balafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 168 people
- Sponsor
- Alcon Research
Corneal Edema
EndoArt® Implantation in Subjects With Chronic Corneal Edema
The EndoArt® is intended to be used as an endothelial prosthesis in patients with chronic corneal edema.The EndoArt® (Artificial Endothelial layer) is a permanent implant, constructed of a clear, transparent, foldable…
- Trial name
- NCT05139771
- Testing
- THE ENDOART® IMPLANTATION (Artificial Endothelial layer)
- Where
- 12 sites in France, Georgia and 4 more
- Volunteers
- 52 people
- Sponsor
- Eye-yon Medical
Corneal Edema
A Safety and Efficacy Study of Corneal Injection for Endothelial Dysfunction Using Human Corneal Endothelial Cell Therapy in Subjects With Corneal Edema Secondary to Endothelial Dysfunction
The purpose of this study is to assess the safety of a fixed dose of human corneal endothelial cells when administered with varying concentrations of Rho kinase inhibitor (Y-27632) in patients with corneal edema secondary to…
- Trial name
- Escalon (NCT05309135)
- Testing
- HCEC-1
- Where
- El Salvador
- Volunteers
- 22 people
- Sponsor
- Aurion Biotech
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Bullous Keratopathy, Corneal Erosion
AONDA Therapeutic Indication Study I
This study will be used to support assessment of AIR OPTIX® NIGHT \& DAY® AQUA (AONDA) Soft Contact Lenses' safety and performance in accordance with updated European Union Medical Device Regulation (EU MDR) requirements.
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05891106
- Testing
- Lotrafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Corneal Edema
A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal Dystrophy
Two different dosing regimens (QD and BID) of netarsudil will be studied to evaluate their efficacy in reducing or resolving corneal edema in subjects with FCD.
- Trial name
- Fuchs (NCT04498169)
- Testing
- Netarsudil Ophthalmic
- Where
- 12 sites in United States
- Volunteers
- 40 people
- Sponsor
- Aerie Pharmaceuticals
Corneal Edema
Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema
The Hyper-CL™ lenses are indicated for therapeutic use as a bandage to protect the corneal surface and to relieve corneal pain in the treatment of acute or chronic ocular pathologies, such as bullous keratopathy, corneal…
- Trial name
- NCT01890252
- Testing
- Hyper CL, saline solution
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Eye-yon Medical
Corneal Edema
Efficacy and Tolerance of Hypertonic Sodium Chloride (NaCl 5%) Eye Drops Without Preservatives in Corneal Edema
Corneal edema is frequently found in clinical practice as a common sign of acute corneal disease due to different etiologies that cause an accumulation of extracellular fluid in the cornea.
- Trial name
- NCT04125394
- Testing
- hypertonic Sodium chloride (NaCl 5%) eye drops solution in single-dose
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Tiedra Farmacéutica SL
CORNEAL EDEMA
Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema
The Hyper-CL™ lenses are indicated for therapeutic use as a bandage to protect the corneal surface and to relieve corneal pain in the treatment of acute or chronic ocular pathologies, such as bullous keratopathy, corneal…
- Trial name
- NCT02660151
- Testing
- Hyper-CL™ lens, Regular soft contact lens, Salt solution
- Where
- 4 sites in Israel, Poland
- Volunteers
- 68 people
- Sponsor
- Eye-yon Medical
Fuchs' Endothelial Dystrophy, Corneal Edema
ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy
Clinical observation to confirm the clinical safety and efficacy of ODM 5 in the treatment of corneal edema caused by Fuchs' endothelial dystrophy.
- Trial name
- NCT02332109
- Testing
- ODM 5
- Where
- 4 sites in Germany
- Volunteers
- 29 people
- Sponsor
- TRB Chemedica AG