Clinical trials: Corneal Ectasia
Keratoconus, Irregular Astigmatism
Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Aberrations are the spreading of light from a point focus. Aberrations of the eyes can be objectively evaluated with a wavefront aberrometer.
- Conditions
- Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront
- Trial name
- WFG Sclerals (NCT04698590)
- Testing
- Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Corneal Ectasia of Both Eyes
Collagen Cross-linking Clinical and Oct Study
1. Assessment of corneal changes in AS-OCT after collagen cross-linking (corneal thickness and demarcation line). 2. Assessment of the effect of collagen cross-linking on best-corrected visual acuity
- Trial name
- NCT05717517
- Testing
- anterior segment oct
- Volunteers
- 100 people
- Sponsor
- Assiut University
Keratoconus, Corneal Diseases
Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.
- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Trial name
- NCT03029104
- Testing
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Where
- 9 sites in United States
- Volunteers
- 2,228 people
- Sponsor
- Cxlusa
Ectasia
Intrastromal Corneal Ring for Ectasia After Refractive Surgery (Anel)
To evaluate the clinical outcomes of intrastromal corneal ring segment (ICRS) implantation to correct keratoconus on eyes with prior refractive surgery.
- Trial name
- NCT02008253
- Testing
- INTRASTROMAL CORNEAL RING SEGMENT
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Instituto de Olhos de Goiania
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Keratoconus, Unstable, Ectasia Corneal
Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position
To determine whether the Peschke PXL-330 is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
- Trial name
- NCT04213885
- Testing
- PXL 330 Platinum device/Riboflavin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eye Specialists of Indiana
Refractive Surgery
Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.
WHAT WAS KNOWN *Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications of the standard protocol were introduces to reduce its complications especially long exposure to ultraviolet rays.
- Trial name
- NCT03791684
- Testing
- Cross linking
- Volunteers
- 111 people
- Sponsor
- Menoufia University
Keratoconus, Ectasia
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01189864
- Testing
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 16 sites in United States
- Volunteers
- 3,493 people
- Sponsor
- Cxlusa
Corneal Ectasia
Evaluating Risk Factors of Post-LASIK Ectasia
Ectasia after refractive surgery is a relatively rare complication which can lead to sight-threatening complications if not detected and treated in time.
- Trial name
- NCT03708575
- Volunteers
- 25 people
- Sponsor
- Assiut University
Keratoconus, Cornea Ectasia
Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking
Corneal ectasia is characterized by irregularity and thinning of the cornea, causing the cornea to bulge forward and cause distorted vision and impaired visual acuity.
- Trial name
- NCT03095235
- Testing
- Dietary riboflavin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04094090
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Goodman Eye Center
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia
This study will determine the efficacy of corneal collagen crosslinking (CXL) combined with Intacs for the treatment of keratoconus and corneal ectasia.
- Trial name
- CXL (NCT01112072)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Ocular Surface Disease
Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE…
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia
- Trial name
- NCT04649177
- Testing
- Ocular surface optical coherence tomography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Keratoconus, Post-Laser Retinal Condition
Investigator Initiated, Prospective Study of Xenia Corneal Lenticule
Cornea ectatic conditions such as keratoconus and post-LASIK (Laser In situ Keratomileusis) ectasia are disorders of the eye that are notorious for its uncontrolled progression over time, leading to loss of vision.
- Trial name
- NCT04741230
- Testing
- Gebauer Lenticule
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Progressive Keratoconus, Corneal Ectasia
Corneal Crosslinking in Keratoconus and Corneal Ectasia
Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoconus or corneal ectasia.
- Trial name
- CXL (NCT00679666)
- Testing
- Riboflavin
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Unstable Corneas
Corneal Cross-Linking Comparing Variables
The purpose of this study is to evaluate the Safety and Efficacy of Corneal Cross Linking in a Continuous Beam versus Pulsed Treatments across epithelium on and epithelium off surfaces.
- Trial name
- NCT02095730
- Testing
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Crowd Health Research, LTD
Keratoconus
PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus
Keratoconus causes irregular astigmatism and reduced vision. Epi-off corneal crosslinking (CXL) stabilizes the cornea but often leaves higher-order aberrations uncorrected.
- Trial name
- PRoTECT (NCT07372911)
- Testing
- Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana