Clinical trials: Corneal Diseases
Dry Eyes, Sjogren's Disease With Dry Eyes
Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
To investigate if fresh finger prick autologous blood (FAB) instead of serum from venesection, is a safe and effective treatment for dry eyes and corneal ulcers/ epithelial defects.
- Conditions
- Dry Eyes, Sjogren's Disease With Dry Eyes, Persistent Corneal Epithelial Defects, Chronic Corneal Ulcers
- Trial name
- FAB (NCT02153515)
- Testing
- Your own ( autologous) finger prick of blood produced with a diabetic lancet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust
Endothelial Cell Loss, Corneal, Cataract
Quantification of Factors Influencing Endothelial Damage During Phacoemulsification
The aim of this study is to determine the principal factors that influence endothelial cell loss three month post cataract surgery. Methods: Multi center observational Cohort study, inclusion period from 12/01/2022 to 10/06/2022.
- Conditions
- Endothelial Cell Loss, Corneal, Cataract, Phacoemulsification
- Trial name
- PREDICSPILOT (NCT05529485)
- Testing
- Cataract surgery by phacoemulsification
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal Disease
Corneal Densitometry Changes With Adenoviral SEI
Adenoviral Sub epithelial infiltrates (SEI) affect ocular function.They lead to reduced vision, photophobia, glare, halos, and foreign body sensation.
- Trial name
- NCT04267991
- Testing
- Tacrolimus ointment, phototherapeutic keratectomy
- Where
- United Arab Emirates
- Volunteers
- 63 people
- Sponsor
- Benha University
Glaucoma, Corneal Damage
Corneal Endothelium After Glaucoma Surgery
The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and…
- Conditions
- Glaucoma, Corneal Damage, Intraocular Pressure
- Trial name
- NCT00863018
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Chungnam National University
Cataract
Level of Agreement of Intraocular Lens Power Measurements Between IOLMaster and Verion
Primary objective of this study is to evaluate the level of agreement of two keratometry modules, the IOLMaster and the Verion Reference Unit, in terms of keratometric values and IOL power calculation.
- Trial name
- NCT03876782
- Testing
- IOLMaster, Verion
- Where
- Greece
- Volunteers
- 54 people
- Sponsor
- Democritus University of Thrace
Limbal Insufficiency, Symblepharon
The Application of Oral Mucosal Epithelial Cell Sheets Cultivated on Amino Membrane in Patients Suffering From Corneal Stem Cell Insufficiency or Symblepharon.
Since cultivated autologous oral mucosal epithelial sheets on amniotic membrane have been reported to have good clinical results in treating patients with ocular surface disorders in both human or animal studies, and such…
- Trial name
- NCT00491959
- Testing
- Cultured oral mucosa cell sheet transplantation
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Myopia
Retardation of Myopia in Orthokeratology
The primary aim of this study is to evaluate and compare the eyeball elongation in children wearing orthokeratology lenses and single-vision spectacles.
- Trial name
- ROMIO (NCT00962208)
- Testing
- orthokeratology lenses, single-vision spectacle lenses
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Uveitis
RNFL Thickness Measurements Obtained Using SD-OCT and SLP Using GDx Variable Corneal Compensation
The aim of this study is to evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP) in uveitic eyes compared…
- Trial name
- Real (NCT03206268)
- Testing
- SD-OCT and SLP using GDx variable corneal compensation
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Keratoconjunctivitis Sicca
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain…
- Trial name
- NCT00411827
- Testing
- PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Keratoconus, Ectasia of Cornea
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07124910
- Testing
- Epi-ON corneal cross-linking
- Where
- 12 sites in United States
- Volunteers
- 485 people
- Sponsor
- Woolfson Eye Institute
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Corneal Neovascularisation
Strategies for Management of Corneal Neovascularisation
The cornea is the transparent window of the eye, which allows light to enter into the eye and also contributes to the focusing of the light rays.
- Trial name
- NCT02594423
- Testing
- Fine Needle Diathermy, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Keratoconus, Irregular; Contour of Cornea
Scleral Lens Fitting Using Wide-Field OCT
The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of…
- Trial name
- NCT04570020
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Oregon Health and Science University
Mixed Astigmatism
Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Mixed Astigmatism
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of mixed astigmatism up to 6.0 D, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00761826
- Testing
- MEL 80 Mixed Astigmatism Treatment
- Where
- 5 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Keratoconus, Fuchs Dystrophy
Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty
This pilot study will compare upto 15 patients undergoing femtolaser assisted keratoplasty (using CE[Conformité Européene] approved femtolaser apparatus) with upto 15 patients undergoing conventional keratoplasty with a manual…
- Conditions
- Keratoconus, Fuchs Dystrophy, Corneal Disease
- Trial name
- NCT03619434
- Testing
- Femtosecond Laser, Trephine blade
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Keratoconus
Customized Contact Lenses
The overall goal of this project is to improve the visual quality of individuals who have abnormal corneal conditions that alter the shape of their cornea (eg. keratoconus).
- Trial name
- NCT05134909
- Testing
- Customized contact lens
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Houston
Disorders, Refractive
A Comparison of Two Devices for Measuring the Central Thickness of the Cornea Before and After Surgery (CECOT)
Corneal topography allows the measure of the radii of curvature and of the thickness of the cornea. It is essential for diagnosis in ophthalmology and allows to highlight corneal irregularities such as a keratoconus, or too thin…
- Trial name
- CECOT (NCT02522416)
- Testing
- Central corneal thickness measurement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Keratoconus
Standard Versus Transepithelial Corneal Crosslinking
The gold standard corneal crosslinking (CXL) technique involves the initial step of epithelial removal, in order to achieve a sufficient treatment effect (meaning: stabilisation of progressive keratoconus (KC).
- Trial name
- NCT02349165
- Testing
- Transepithelial versus epithelium-off CXL, Ricrolin TE, Isotonic riboflavin
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Nienke Soeters
Bullous Keratopathy, Corneal Erosion
AONDA Therapeutic Indication Study I
This study will be used to support assessment of AIR OPTIX® NIGHT \& DAY® AQUA (AONDA) Soft Contact Lenses' safety and performance in accordance with updated European Union Medical Device Regulation (EU MDR) requirements.
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05891106
- Testing
- Lotrafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Fuchs' Endothelial Dystrophy, Cataract
The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery
The purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with FED after femtosecond laser assisted cataract surgery.
- Trial name
- NCT06048380
- Testing
- Ripasudil
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore Eye Research Institute
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