Clinical trials: Corneal Diseases
- Condition Corneal Diseases
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Presbyopia
A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near Vision in Presbyopic Patients
This study will be a prospective, multicenter clinical trial in which a total of 400 subjects will be enrolled. All subjects will be followed over a 36 month time frame with a maximum of 15 clinical sites participating.
- Trial name
- NCT01373580
- Testing
- The Raindrop Near Vision Inlay
- Where
- 11 sites in United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- ReVision Optics, Inc.
Cataract, Healthy Eye
The Heidelberg Engineering ANTERION Anterior Segment Cornea and IOL Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess anterior segment parameters with the ANTERION
- Conditions
- Cataract, Healthy Eye, Cornea Abnormality, Post-Keratorefractive Surgery
- Trial name
- NCT04130490
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Presbyopia
Safety and Efficacy of an Intrastromal Transform™ Corneal Allograft (TCA) for Presbyopia Correction
The objective of this clinical study is to evaluate the safety and effectiveness of intrastromal implantation of the Allotex TransForm corneal allograft (TCA) for improving near vision in presbyopic subjects.
- Trial name
- NCT03671135
- Testing
- TCA Intrastromal Inlay
- Where
- 4 sites in Belgium, Ireland and 1 more
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Allotex, Inc.
Hyperopia
Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of hyperopia, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00762281
- Testing
- MEL 80 Hyperopic LASIK Treatment
- Where
- 6 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Healthy, Keratoconus
Comparison of WaveLight Analyzer and Alcon LadarWave
Comparison of repeated WaveLight Analyzer and Alcon LadarWave measurements in phakic and pseudophakic eyes.
- Trial name
- NCT00863876
- Where
- Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- WaveLight AG
Ametropia
Endothelial Bleb Response With Toric Lenses
Evaluate the short-term corneal response of oxygen deprivation when using toric contact lenses. The response will be noted by endothelial bleb formation in both open eye and closed eye state.
- Trial name
- NCT00630305
- Testing
- alphafilcon A toric, lotrafilcon B toric, senofilcon A toric
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Acanthamoeba Keratitis
Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects
Randomized, double-masked, placebo-controlled, multiple center, parallel-group Phase 1 study to evaluate the safety and tolerability of 3 doses of preservative-free PHMB ophthalmic solution compared to placebo in healthy subjects
- Trial name
- NCT02506257
- Testing
- 0.04% PHMB, 0.06% PHMB, 0.08% PHMB
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- SIFI SpA
Myopia
Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Moderate to High Myopia
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of moderate to high myopia (nearsightedness), when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00762541
- Testing
- MEL 80 Treatment of High Myopia
- Where
- 5 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Normal Cornea, Corneal Abnormality
The Heidelberg Engineering ANTERION Corneal Epithelium Thickness Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess corneal epithelial thickness parameters with the ANTERION
- Trial name
- NCT05051813
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Myopia
Corneal Refractive Therapy Design Comparison for -4 to -6 Diopter Treatment for Overnight Wear for Myopia
The primary objective of this study is to compare the effectiveness of two proximity control geometry lens designs to treat eyes with pretreatment myopia between -4.00 and -6.00 D myopia with and without refractive astigmatism in…
- Trial name
- NCT05438615
- Testing
- Corneal Refractive Therapy-spherical, Corneal Refractive Therapy-aspherical
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)
Corneal Neovascularization
Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment
A Phase 1 randomized, double blinded, placebo-controlled, single dose escalation (SDE) and repeat dose escalation (RDE) study to evaluate safety and tolerability, and PK of KDR2-2 in healthy volunteers.
- Trial name
- NCT04620109
- Testing
- KDR2-2
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Guangzhou HuiBoRui Biological Pharmaceutical Technology Co. Ltd
Glaucoma, Retinal Disease
OCT Agreement and Crossed Precision Study
The purpose of this study is to asses the agreement of the RS-3000 Lite and RS-3000 Advance to the RS-3000, assess the crossed precision of each study device and to assess the transference of a reference database from the RS-3000…
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT02050880
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Glaucoma, Retinal Disease
Nidek RS3000 Comparative Study
The primary objective of this clinical study is to compare the Nidek RS-3000 Optical Coherence Tomography (OCT) device to the Optovue RTVue OCT.
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT01384487
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Retinal Disease
Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- COMFORT (NCT05750589)
- Testing
- IRX-101, Providone-Iodine
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Corneal Diseases
Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions
The purpose of this study is to determine the ability of a proprietary software screening tool to discriminate normal corneas (front surface of the eye) from previously diagnosed corneal conditions…
- Trial name
- NCT00396188
- Where
- 4 sites in United States
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Myopia
Post-market Follow Up Study on Paragon CRT® 100 (Paflufocon D)
The main objective of this post market clinical study is to evaluate the effectiveness and safety of the Paragon CRT®100 Contact Lens.
- Trial name
- NCT04187599
- Testing
- Paragon CRT®100 Contact Lens
- Where
- 4 sites in China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)
Cataract, Keratoconus
Clinical Study - ES 900 - 2020-2
The EYESTAR 900 with software version i9.5.1.0 includes new analysis functionality. Since its clinical performance cannot be assessed based solely on clinical literature as found in the Clinical Evaluation Report, further data…
- Trial name
- NCT04392349
- Testing
- Haag-Streit EYESTAR 900, Tomey CASIA 2, Oculus PENTACAM HR
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Haag-Streit AG
Astigmatism
Corneal Astigmatism Measurement Study
To assess which commercially available measurement device is most accurate in measuring low (< 1.0 D) degrees of corneal astigmatism.
- Trial name
- NCT00818532
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Retinal Disease
SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- RELIEF (NCT05747430)
- Testing
- IRX-101, Providone-Iodine
- Where
- 7 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Healthy Cornea
Evaluation of Corneal Endothelium Health Following Articaine Ophthalmic Solution Administration
The goal of this clinical trial is to evaluate the corneal endothelium health of eyes treated with articaine ophthalmic solution in adult participants.
- Trial name
- NCT07838129
- Testing
- Articaine (CYKLX), Vehicle
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea