Clinical trials: Corneal Crosslinking
Keratoconus
Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Randomized Trial (SHARK)
The goal of this clinical trial is to compare CXL with combined treatment with CXL and t-PTK. The main questions it aims to answer are whether combined treatment can give better visual acuity and if the treatments are equally…
- Trial name
- NCT06264024
- Testing
- Corneal collagen cross linking (CXL), Transepithelial phototherapeutic keratectomy (t-PTK)
- Where
- Norway
- Volunteers
- 81 people
- Sponsor
- Oslo University Hospital
Keratoconus
Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized.
- Trial name
- C-CROSS (NCT04532788)
- Testing
- Customized crosslinking, Standard crosslinking
- Where
- 3 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Keratoconus, Corneal Ectasia
Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT01464268
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
Conventional Collagen Crosslinking in Young Keratoconus
Keratoconus is a chronic progressive non - inflammatory disorder characterised by progressive steepening and thinning of cornea and high myopic astigmatism, accounting for poor visual acuity in such individuals.
- Trial name
- PED-CXL (NCT02008175)
- Testing
- Conventional CXL
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Vasan Eye Care Hospital
IOP Readings Before and After Accelerated Corneal Collagen Crosslinking (CXL)
IOP Measurements Using ORA After ACXL in Keratoconus
The investigators measured IOP by Goldmann applanation tonometry(GAT) before and 6 months after accelerated 8 minutes CXL in using Avedro Kxl ,and correlated with corneal resistance factor(CRF)using ORA, AC angle and CCT using…
- Trial name
- NCT04464083
- Testing
- IOP Measurment
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Corneal Ectasia Disorders Including Keratoconus
The Effects of Corneal Collagen Cross-linking
The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as "keratoconus." Recent advances have allowed different techniques for performing this cross-linking treatment.
- Trial name
- NCT01708538
- Testing
- CXL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush Eye Associates
Keratoconus, Corneal Crosslinking
Epi-on PiXL for the Treatment of Progressive Keratoconus.
The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by individually customized Photorefractive intrastromal crosslinking (PiXL) without epithelium debridement in high oxygen…
- Conditions
- Keratoconus, Corneal Crosslinking, Corneal Densitometry, Scheimpflug Photography
- Trial name
- NCT04668924
- Testing
- Epi-on PiXL in high oxygen
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia
This study will determine the efficacy of corneal collagen crosslinking (CXL) combined with Intacs for the treatment of keratoconus and corneal ectasia.
- Trial name
- CXL (NCT01112072)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Corneal Neovascularization
Corneal Crosslinking for Treatment of Corneal Neovascularization
The study objective is to assess safety and efficacy of photo-activation of riboflavin for treatment of corneal neovascularization with or without concomitant inflammation and/or infection.
- Trial name
- NCT04787471
- Testing
- 30 minute photoactivation of riboflavin 0.1%, 10 minute photoactivation of riboflavin 0.1%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Price Vision Group
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus, Ectasia
UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
The primary objective of this study is to evaluate two different ultraviolet (UV) dosing regimens for corneal collagen cross linking to slow the progressive changes in corneal curvature in eyes with progressive keratoconus or…
- Conditions
- Keratoconus, Ectasia, Corneal Ectasia
- Trial name
- NCT01325298
- Testing
- UV-X Light, Riboflavin
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mercy Center for Corrective Eye Surgery
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Corneal Melting in Boston Keratoprosthesis Type I
Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting
The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston…
- Trial name
- CXL-KPro (NCT03041883)
- Testing
- Crosslinking with riboflavin of the corneal graft-support, De-epithelisation of the corneal graft support with instillation of riboflavin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Brittle Cornea Syndrome, Ehlers-Danlos Syndrome Type 6
Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI
Brittle Cornea Syndrome and Ehlers-Danlos Syndrome (EDS) type VI are rare collagen-connective tissue disorders that predispose affected individuals to the development of perforated corneas from the mildest of eye trauma or even…
- Trial name
- NCT01307527
- Testing
- Riboflavin, Kera-X
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- Hadassah Medical Organization
Dry Eye Disease
IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL
A Randomized, Controlled, Double-Masked, Two-Arm Investigator-Initiated study to Assess the Efficacy of OC-01 (varenicline) Nasal Spray on signs and symptoms of Dry Eye Disease in subjects following Corneal Collagen Crosslinking…
- Trial name
- NCT05136924
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision - MT
Myopia, Corneal Crosslinking
Photorefractive Intrastromal Corneal Crosslinking as a Treatment for Low Grade Myopia
To assess the improvement in refractive error and the corneal endothelial safety with a customized corneal crosslinking treatment regimen for low grade myopia.
- Conditions
- Myopia, Corneal Crosslinking, Refractive Errors, Eye Diseases
- Trial name
- NCT03987880
- Testing
- 4.0 mm treatment, 3.5 mm treatment
- Where
- Sweden
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Umeå University
Keratoconus
Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus
Background: Corneal cross linking is a procedure that induces collagen cross linking of the corneal stroma due to release of reactive oxygen radicals upon activation of topically applied riboflavine A by UVA exposure.
- Trial name
- CCL (NCT00626717)
- Testing
- Riboflavin/UVA crosslinking
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Freiburg
Keratoconus
Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT.
Objectives: Measurement of corneal stiffness parameters { Deformation Amlitude (DAR1), Integrated radius, Stress parameter (SP A1), Stress strain index (SSI) and Corvis biomechanical index (CBI) } in keratoconic corneas before…
- Trial name
- NCT05161052
- Testing
- Corvis ST (dynamic Scheimpflug technology)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cairo University
Keratoconus
Corneal Collagen Crosslinking With Riboflavin for Keratoconus Treatment: A Brazilian Study
Cross-linking of the cornea increases the mechanical and biochemical stability of the stromal tissue. The purpose of this study is to assess the effectiveness of riboflavin-ultraviolet light induced cross-linking of corneal…
- Trial name
- NCT00642044
- Testing
- Corneal Collagen Crosslinking
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Federal do Rio de Janeiro