Clinical trials: Control
ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation
Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT
Acute Respiratory Distress Syndrome (ARDS) is a serious condition where the lungs become inflamed, leading to severe breathing difficulties.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation, Patient-Self Inflicted Lung Injury
- Trial name
- OSIRIS-1 (NCT07588217)
- Testing
- Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Elevated Triglycerides, Hypertriglyceridemia
Effects of Replacing Energy From Solid Fats and Added Sugars (SoFAS) With Avocado
The objective of this study is to assess the effects of replacing energy from SoFAS with energy from avocado on non-high-density lipoprotein cholesterol (non-HDL-C) and other aspects of the cardiometabolic health profile…
- Trial name
- NCT04990817
- Testing
- Average American Diet With SoFAS Replaced With Avocado, Average American Diet
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Low Mood, Depressive Symptoms
The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood
A randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of 8 weeks of supplementation with Bifidobacterium longum 1714® strain on Beck's Depression Inventory-II Score in adults who experience low mood.
- Trial name
- NCT04925440
- Testing
- Bifidobacterium longum 1714® strain
- Where
- Ireland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- PrecisionBiotics Group Ltd.
Bipolar Disorder, Bipolar Depression
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
This is a randomized, double-blind, placebo-controlled study of the investigational drug uridine as a treatment for depressed adolescents with bipolar disorder (i.e. "bipolar depression").
- Conditions
- Bipolar Disorder, Bipolar Depression, Manic Depression
- Trial name
- NCT01805440
- Testing
- Uridine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Utah
Positive Parenting
An Adapted Evidence-Based Coaching Program for Fathers and Their Young Children in the Context of Home Visiting
Father-child pairs (N=200; children ages 12-36 months) will be randomized to FIND-F or a waitlist control group. Assessments comparing the two groups will occur at baseline, end of program, and 6 months post-program.
- Trial name
- NCT07676240
- Testing
- Filming Interactions to Nurture Development (FIND)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Washington
Schizophrenia
Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-1117568 in Adults With Schizophrenia
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, multi-arm, multi-stage inpatient study designed to assess the efficacy, safety, tolerability, and pharmacokinetics (PK) of NBI-1117568 compared with…
- Trial name
- NCT05545111
- Testing
- NBI-1117568
- Where
- 15 sites in United States
- Volunteers
- 210 people
- Sponsor
- Neurocrine Biosciences
Lung Disease, Pulmonary Lobectomy
PleuraSeal Post Market Study (Europe)
To further characterize the PleuraSeal Sealant System as compared to standard of care (sutures and staples only) in subjects undergoing an elective pulmonary lobectomy and segmentectomy via open thoractomy.
- Trial name
- NCT00704171
- Testing
- Standard Tissue Closure Techniques, PleuraSeal Lung Sealant System
- Where
- 9 sites in United States, Austria and 4 more
- Volunteers
- 121 people
- Sponsor
- Integra LifeSciences Corporation
Behavioral Symptoms, Autistic Disorder
Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD)
This study will compare the effectiveness (how well the drug works) of aripiprazole with placebo (fixed dose) in reducing serious behavioral problems in children and adolescents with a diagnosis of autistic disorder (AD).
- Trial name
- NCT00337571
- Testing
- Aripiprazole
- Where
- 31 sites in United States
- Volunteers
- 218 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Scar
Postoperative Skin Surface Tension Relaxing in Prevention of Facial Surgical Skin Scarring
The purpose of this study is to evaluate the efficacy and safety of early postoperative skin surface reduction in improving scar formation after facial surgery.
- Trial name
- NCT03842644
- Testing
- Tension reduction device
- Where
- China
- Volunteers
- 55 people
- Sponsor
- XiaoXi Lin
Atelectasis
Chest Compression Technique in Infants
Evaluate the effect of chest manual compression technique (CCT) in the variables of oxygenation, hemodynamic and respiratory work in infants with respiratory diseases that are associated with atelectasis.
- Trial name
- NCT01858844
- Testing
- CHEST COMPRESSION TECHNIQUE (CCT)
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Diabetes, Kidney Disease
Improving Outcomes in Patients With Kidney Disease Due to Diabetes
Kidney disease affects about one out of three people with diabetes mellitus, a common medical problem. Treatment of kidney disease with medications that lower blood pressure can slow the kidney disease but there is no known cure.
- Conditions
- Diabetes, Kidney Disease, Hypertension
- Trial name
- NCT00381134
- Testing
- losartan 100 mg orally once daily, spironolactone 25 mg orally once daily
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Psychological Trauma, Stress Disorders, Post-Traumatic; Mental Disorders
Trauma-Focused Group Therapy for Adults With Trauma-Related Symptoms in Primary Care
Psychological trauma is common and can lead to long-lasting emotional distress, difficulties in daily functioning, and reduced quality of life.
- Trial name
- NCT07757334
- Testing
- Trauma-Focused Group Intervention, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Luis Eduardo Estévez Cachafeiro
Naltrexone, Methylphenidate Abuse
Study for Naltrexone on the Abuse Potential of Methylphenidate
The current abuse liability study aims to assess the potential for co-administration of naltrexone (NTX) to reduce the abuse potential of methylphenidate (MPH).
- Trial name
- NCT03769064
- Testing
- Methylphenidate 60 mg, Treatment Phase Sequence 4213, Treatment Phase Sequence 2134
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Avekshan LLC
Gastric Intestinal Metaplasia
Efficacy of an AI System in Training Endoscopists to Assess Gastric Intestinal Metaplasia Via the EGGIM Score
This prospective randomized controlled trial with a crossover design incorporated image-enhanced endoscopy (IEE) videos demonstrating complete standardized examinations of five standard gastric areas (antrum greater curvature…
- Trial name
- NCT07208864
- Testing
- AI-assisted EGGIM scoring, Conventional EGGIM scoring
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qilu Hospital of Shandong University
Condylar Remodeling Exercises, CCM Malalignment
To Investigate the Effect of Condylar Remodeling Exercises on Proprioception of Neck and Temporomandibular Joint in Cranio-cervico-mandibular Malalignment.
Cranio-cervico-mandibular (CCM) malalignment is associated with forward head posture (FHP) and tempromandibular joint (TMJ) disorders and affects masticatory muscles.
- Trial name
- NCT07642609
- Testing
- Condylar remodeling exercises Included 1)Range of motion phase, 2)Bite phase, 3)Bite return phase, 4)Protrusion, 5)isometric contraction phase Tubing distraction phase, Postural correction exercises Kendall exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Tooth Extraction
The Effect of Alveolar Ridge Preservation After Tooth Extraction in the Posterior Maxilla
This study is designed to assess the effects of Alveolar Ridge Preservation (ARP) after tooth extraction compared to extraction alone in the posterior maxilla.
- Trial name
- NCT02952209
- Testing
- Xenograft
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Cardiovascular Diseases
Effects of the Low-level Laser Therapy on Inflammatory Profile of the Patients With Coronary Artery Bypass Surgery
Cardiovascular diseases are the leading causes of morbidity and mortality in Brazil and surgical procedures to treat these disorders have grown dramatically in recent years.
- Trial name
- NCT02709499
- Testing
- 0J LLLT, 6J LLLT
- Volunteers
- 38 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Endometriosis
Efficacy and Safety of SH T00660AA in Treatment of Endometriosis
The purpose of this study is to demonstrate safety and efficacy of SH T00660AA compared to placebo in the treatment of endometriosis
- Trial name
- NCT00225199
- Testing
- Visanne (BAY86-5258, SH T00660AA)
- Volunteers
- 198 people
- Sponsor
- Bayer
Dentin Hypersensitivity, Post Operative Sensitivity Control
Dipotassium Oxalate for Postoperative Sensitivity in NCCLs
Postoperative sensitivity is a common complication following Class V composite restorations, particularly in non-carious cervical lesions (NCCLs).
- Trial name
- DIPOX-RCT (NCT07540299)
- Testing
- Dipotassium Oxalate Gel
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Hepatitis C Virus
TMC435-TiDP16-C125 - Study in Healthy Volunteers to Evaluate the Potential of TMC435 to Increase the Sensitivity of the Skin Towards Exposure to Sun Light
The purpose of the study is to evaluate the potential effect of TMC435 on the sensitivity of the skin towards exposure to sunlight.
- Trial name
- NCT01124799
- Testing
- TMC435, Ciprofloxacin
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland