Clinical trials: Contractions
Chest Pain Atypical Syndrome
Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Non-cardiac chest pain (NCCP) is a common disorder whose pathophysiology is poorly understood. Some evidence suggests it may be related to sustained esophageal contractions (SECs) of longitudinal smooth muscle.
- Trial name
- NCT01839058
- Testing
- Esophageal Manometry
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Queen's University
Postpartum Hemorrhage
Investigating the Effect of Pulsatile Administration of Oxytocin on the Desensitization of Human Myometrium In-vitro
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle (myometrium) tone after delivery.
- Trial name
- NCT02338089
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Thumb Joint Stiffness
Electrical Stimulation to Recover Greater Range of Motion After Surgery
Background One of the potentially debilitative complications of operative repair and subsequent immobilization is stiffness that appears secondary to inflammation and adhesions.
- Trial name
- NCT01082432
- Testing
- electrically induced muscle activation
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Joseph Fourier
Obstructive Sleep Apnea, Breathing, Sleep-Disordered
Cheeks Appearance as a Novel Predictor of Obstructive Sleep Apnea The CASA Score Study
Cheeks appearance is a screening tool developed based on cheeks observation to identify volume, flaccidity or both to predict people with probable obstructive sleep apnea.
- Conditions
- Obstructive Sleep Apnea, Breathing, Sleep-Disordered, Muscle Weakness, Muscle Disorder
- Trial name
- CASA (NCT04980586)
- Testing
- CASA score protocol to Non-obstructive sleep apnea Group, CASA score protocol to Mild obstructive sleep apnea Group, CASA score protocol to Moderate obstructive sleep apnea Group
- Where
- Brazil
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pre Term Labor, Multiple Pregnancy
Study to Support Fetal Heart Rate and Uterine Contraction for Preterm Labor in Singleton and Multiple Pregnancies
The purpose of this study is to compare the Monica AN24 fetal monitor to previously FDA approved devices for Fetal Heart Rate and Uterine Contractions in labor for Multiples and pre term labor.
- Trial name
- NCT01360905
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Monica Healthcare Ltd
Ventricular Premature Complexes, Atrial Premature Complexes
Oral Magnesium Supplementation in Athletes With Premature Ventricular Contractions or Premature Atrial Contractions.
Magnesium is a mineral which is essential to many of the processes which happen in the body. This includes normal function of muscles; including the heart.
- Trial name
- NCT04186728
- Testing
- Magnesium glycinate
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pelvic Floor Muscle Weakness
Comparison of Teaching Methods of Pelvic Floor Muscle Contraction in Women
The aim of our study; To evaluate the effectiveness of different teaching methods on correct pelvic floor muscle contraction in women who have not received pelvic floor muscle training (PFMT) before.
- Trial name
- NCT06306703
- Testing
- group1, group2, group 3
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Duygu Sultan Oge
Healthy
Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways
In this study, the investigators will evaluate if the food intake associated with the infusion of erythromycin is caused by the phase 3 contractions or by another yet unknown effect of erythromycin.
- Trial name
- NCT02633579
- Testing
- erythromycin lactobionate, Atropine, Erythromycin with atropine
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Premature Ventricular Contractions
Concealed Myocardial Abnormalities by Cardiac Magnetic Resonance Imaging in Idiopathic VT
Idiopathic Ventricular arrhythmia (VAs) refers to VAs that occur in the absence of clinically apparent structural heart disease.
- Trial name
- NCT06146556
- Testing
- catheter based ablation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Maximum Voluntary Contraction
Muscular Force Generation in Microgravity
The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals.
- Trial name
- ForceGeneratio (NCT02850328)
- Testing
- examination of muscle function and MVC in weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Dystocia, Contractions
Internal Versus External Tocodynamometry and Labor Outcome
In this study, parturients will be randomized to either internal or external tocodynamometry contractions' follow up. Investigators recruit primiparous, those who try to have vaginal birth after cesarean section and multiparous…
- Trial name
- NCT02941393
- Testing
- Intrauterine pressure catheter, External tocodynamometry
- Where
- 2 sites in Finland
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Stroke, Paralysis Arm
PNS Motor Stimulation Study
Paralysis is one of the most disabling features of Spinal cord injury and stroke. In select cases, where the nerve is intact, stimulation can achieve meaningful muscle contraction e.g. to restore grip and release function.
- Conditions
- Stroke, Paralysis Arm, Spinal Cord Injury
- Trial name
- NCT07810712
- Testing
- Stimulation of the motor unit
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Walton Centre NHS Foundation Trust
Premature Ventricular Contractions
Use of MIBG Scan Images in PVC Ablations
The purpose of this study is to assess if Single Photon Emission Computed Tomography (SPECT) demonstrating cardiac innervation can be integrated into current electrophysiology voltage mapping system and provide improved guidance…
- Trial name
- PVC-MIBG (NCT02279030)
- Testing
- MIBG nuclear scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy Control Subjects
Optimisation of Eccentric Exercises
Regular physical activity is an important public health lever and is recognised as an alternative in the management of certain long-term conditions.
- Trial name
- OPTIMEX (NCT06193824)
- Testing
- Experimental: downhill treadmill walking at -10% and -20% gradient
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Resistance Training, Eccentric Exercise Training
EFFECT OF RESISTANCE TRAINING VOLUME WITH INERTIAL FLYWHEEL ON MUSCLE ADAPTATIONS IN UNTRAINED MEN
Muscular strength is essential for health and quality of life, impacting body composition, balance, locomotion, functional independence, and mental health.
- Trial name
- RCT (NCT06924060)
- Testing
- Flywheel Resistance Training with two sets, Flywheel Resistance Training with four sets, Flywheel Resistance Training with six sets
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Vicosa
Exercise Induced Muscle Damage, Cryotherapy
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more…
- Trial name
- NCT07211412
- Testing
- Cryotherapy, Eccentric exercise-induced muscle damage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Postpartum Hemorrhage, Uterine Atony
Comparison of Effect of Two Different Doses of Intravenous Oxytocin on Patients Undergoing Elective Cesarean Section
Uterine atony and postpartum hemorrhage are important causes of maternal morbidity and mortality following cesarean section. Oxytocin is routinely administered to stimulate uterine contractions and prevent postpartum uterine…
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Elective Cesarean Section
- Trial name
- OXY-CS (NCT07922083)
- Testing
- Oxytocin 5 IU (Low Dose), Oxytocin 10 IU (High Dose)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shalamar Hospital
Pelvic Floor, Motor İmagery Ability
Validity and Reliability of the Kinesthetic Motor Imagery of Pelvic Floor Muscle Contraction Questionnaire in Turkish
The aim of this study is to adapt the questionnaire named "Kinesthetic Motor Imagery of Pelvic Floor Muscle Contraction Questionnaire (KMI-PFQ)" into Turkish in healthy women and to introduce it to the literature as a valid and…
- Trial name
- NCT06882694
- Testing
- Pelvic Floor Imagery Questionairre
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Knee Arthritis, Osteoarthritis, Osteo Arthritis of the Knee
Quadriceps Muscle Quality and Clinical Outcomes in Knee Osteoarthritis
The purpose of this cross-sectional, observational study is to evaluate the relationship between quadriceps muscle quality-specifically muscle echogenicity and thickness change during isometric contraction-and clinical outcomes…
- Trial name
- NCT07541274
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital