Clinical trials: Contraception
HIV Infections, Contraception
DYnamic decisioN Support for IntegrAting PrEP in Clinics for Young People in Alabama and Botswana
This study evaluates strategies to improve access to HIV prevention through the integration of pre-exposure prophylaxis (PrEP) into existing healthcare settings, rather than limiting delivery to specialty clinics.
- Conditions
- HIV Infections, Contraception, PrEP
- Trial name
- DYNAMIC PrEP (NCT07597824)
- Testing
- Observational cohort (PrEP use in real-world settings)
- Where
- Botswana
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy, Fertility
Creighton Model Effectiveness, Intentions and Behaviors Assessment (CEIBA)
The Creighton Model (CrM) FertilityCare System is a natural family planning method that teaches couples to recognize and chart the signs of fertility and infertility in the woman's cycle and to use that knowledge to either…
- Trial name
- CEIBA (NCT01012596)
- Testing
- Creighton Model System of Natural Family Planning
- Where
- 18 sites in United States, Canada
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- University of Utah
Postpartum Family Planning
Impact Evaluation of a Targeted mHealth Intervention to Improve Uptake of Postpartum Contraception in Kenya
The goal of this study is to explore approaches to improve postpartum contraceptive counseling, information, and uptake through a collaboration between the Harvard Chan School, Rutgers School of Public Health, Jacaranda Health…
- Trial name
- NCT06266780
- Testing
- PROMPTS Enhanced Family Planning Counselling
- Where
- Kenya
- Volunteers
- 4,190 people, healthy volunteers welcome
- Sponsor
- Jacaranda Health
Contraception, Menopause
Study Conducted to Further Understand the Elimination Pathways, Metabolite Profile and PK Profile of 14C-estetrol
This study is being conducted to further understand the elimination pathways, metabolite profile and pharmacokinetic (PK) profile of carbon 14 labelled estetrol ([14C] estetrol).
- Trial name
- NCT02720224
- Testing
- Estetrol
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Estetra
Contraception
Comparative Efficacy of Lidocaine Spray Versus Vaginal Dinoprostone in IUD Insertion
the aim of this study is to compare the safety and Efficacy of Lidocaine Spray Versus Vaginal dinoprostone in relieving pain during levonorgestrel IUD Insertion in nulliparous women
- Trial name
- NCT04339361
- Testing
- lidocaine spray, vaginal dinoprostone
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hormonal Intrauterine Contraception
The Aim of This Study is to Estimate the Discontinuation Rate of Low-dose Levonorgestrel-releasing Intrauterine System Due to Self-reported Unacceptable Menstrual Bleeding Pattern in Spanish Women Who Are Using it for the First Time How Intrauterine System for Long Acting Contraception
Researchers are looking for better ways to help women prevent pregnancy. Every month, a woman's body prepares for pregnancy in a process called the menstrual cycle. When pregnancy does not happen, menstruation occurs.
- Trial name
- CORA (NCT04785950)
- Testing
- Low-dose levonorgestrel intrauterine systems (LNG-IUS)
- Where
- Spain
- Volunteers
- 316 people
- Sponsor
- Bayer
Abortion
Trial of Immediate Versus Delayed Initiation of Transdermal Hormonal Contraception After Therapeutic Abortion
This is a randomized, controlled trial investigating whether immediate versus standard, "Sunday Start", initiation of transdermal hormonal contraception (the patch) in post-abortion subjects can improve compliance and the…
- Trial name
- NCT00235547
- Testing
- timing of initiation of transdermal patch after an abortion
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy (Unwanted), Sexually Transmitted Disease (STD)
#TranscendentHealth: A Text Messaging Pregnancy Prevention Program for Transgender Boys
Transgender and gender-diverse young people who were assigned female at birth (AFAB), including transgender boys, nonbinary youth, and others, face real sexual health disparities.
- Conditions
- Pregnancy (Unwanted), Sexually Transmitted Disease (STD), HIV Infection, Sexual Behavior
- Trial name
- THPP (NCT07681908)
- Testing
- #TranscendentHealth, Universal Sexual Health Program
- Where
- United States
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Contraception
Ethyl Chloride Spray Versus Subcutaneous Lidocaine Anaesthetic Prior to Contraceptive Implant Insertion
Study to look at the acceptability of local anaesthetic spray versus injection, prior to contraceptive implant insertion
- Trial name
- NCT02651207
- Testing
- Questionnaire based study looking at pain scores felt by patients either having a lidocaine injection or ethyl chloride spray prior to insertion of a contraceptive implant
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tayside Medical Science Centre
Contraception
An Open-label Study to Evaluate Contraceptive Efficacy and Safety of the Transdermal Contraceptive System of Norelgestromine and Ethinyl Estradiol
The purpose of this study is to evaluate the contraceptive efficacy, safety, cycle control, compliance, and subject satisfaction of the transdermal contraceptive system, norelgestromine and ethinyl estradiol (NLGM / EE).
- Trial name
- NCT00307632
- Testing
- Norelgestromine (NLGM)/ethinyl estradiol (EE)
- Where
- 12 sites in Brazil, Mexico
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag Farmaceutica Ltda.
Female Contraception
Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small.
- Trial name
- WOMEN&More (NCT06394999)
- Testing
- Mifepristone 50 mg
- Where
- 14 sites in Netherlands
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pharmacokinetics
The Pharmacokinetics of 12 Week Continuous Patch Use
Investigators propose a descriptive pharmacokinetic study of the serum hormone levels of estrogen and progesterone with extended use (12 weeks) of the contraceptive patch.
- Trial name
- NCT02585999
- Testing
- Xulane Contraceptive Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Diabetes Mellitus, Type 2
A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause
Novo Nordisk is developing a combination therapy with the investigational drug NNC0480-0389 and an already approved medicine called "semaglutide" for the treatment of type-2 diabetes (T2D).
- Trial name
- NCT05153564
- Testing
- Semaglutide 1.34 mg/mL, Semaglutide 3.0 mg/mL, NNC0480-0389 10 mg/mL
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy
Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Men
This is a prospective, randomized, double-blinded, two-center trial to evaluate the gonadotropin suppressive activity of transdermal treatment with a combined NES/T gel, or T gel alone, for 28 days.
- Trial name
- NCT02432261
- Testing
- Nestorone® /testosterone gel, Testosterone only gel
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
IUD, Contraception
IUD Self-Removal: Evaluating an Online Guide for Self-removal in Clinical and Non-clinical Settings
Investigators previously developed a guide to help people with IUD self-removal. In this randomized study, the goal is to see if this guide makes it easier for IUD-users to remove their own IUDs.
- Trial name
- NCT06042556
- Testing
- IUD self-removal guide
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Washington
Breastfeeding, Post Partum
Acceptability & Tolerance of Immediate Versus Delayed Postpartum Contraceptive Implant
To study and compare acceptability and tolerance between breast-feeding post-partum woman, who receive contraceptive implant 48-72 hours after giving birth or at 5-7 weeks after giving birth, using either Levonorgestrel or…
- Trial name
- NCT03353012
- Testing
- Etonogestrel Drug Implant, Levonorgestrel Drug Implant
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Pregnancy
Better Contraceptive Choices: Immediate or Delayed Insertion of IUC After Second Trimester Abortion
Hypothesis Intrauterine contraception placed immediately after a second trimester abortion will result in fewer pregnancies than current standard practice of intended placement at 4 weeks post-abortion.
- Trial name
- NCT00877344
- Testing
- Immediate insertion, Interval insertion
- Where
- 3 sites in Canada
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Contraception
YAZ, Oral Contraceptive Registration in China
The purpose of this study is to evaluate the effectiveness in terms of prevention of pregnancy and safety of the oral contraceptive YAZ in healthy Chinese women.
- Trial name
- NCT00819312
- Testing
- YAZ (SH T00186, BAY86-5300)
- Where
- 17 sites in China, Hong Kong
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- Bayer
Sex, Unprotected Sex
Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents
The objective of this research study is to evaluate a culturally tailored sexual and reproductive health intervention among American Indian (AI) youth.
- Conditions
- Sex, Unprotected Sex, Contraception, Alcohol Use
- Trial name
- TPP (NCT02904629)
- Testing
- Respecting the Circle of Life (RCL), Control Program
- Where
- United States
- Volunteers
- 1,072 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health