Clinical trials: Continuous Insulin Infusion System
Type 1 Diabetes Mellitus
Assessment of the Safety of SAR342434 and Humalog® When Administered as Continuous Subcutaneous Insulin Infusion
Primary Objective: Assess the safety of SAR342434 and Humalog when used in external pumps. Secondary Objectives: Intervals for infusion set changes. Incidence of insulin pump alarms for infusion set occlusion.
- Trial name
- NCT02603510
- Testing
- SAR342434, insulin lispro
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 2 Diabetes
Validation of Insulin Dose Prediction Model Based on Artificial Intelligence Algorithm
The present study aims to conduct a prospective controlled trial comparing an LSTM-based artificial intelligence (AI) prediction model and clinicians' experience in the efficacy and safety of blood glucose control in hospitalized…
- Trial name
- NCT07066891
- Testing
- CSII in the prediction model group, CSII in the empirical group
- Where
- China
- Volunteers
- 203 people
- Sponsor
- Sun Yat-sen University
Type 1 Diabetes Mellitus
Safety Assessment of SAR341402 and NovoLog® Used in Continuous Subcutaneous Insulin Infusion for Type 1 Diabetes Mellitus Patients
Primary Objective: To assess the safety of SAR341402 and NovoLog® when used in external insulin pumps in terms of the number of patients with infusion set occlusions.
- Trial name
- NCT03436498
- Testing
- Insulin aspart SAR341402, Insulin aspart
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1
A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to learn more about a new formulation of insulin lispro when given by an insulin pump to participants with type 1 diabetes mellitus.
- Trial name
- NCT04161976
- Testing
- LY900027, Insulin Lispro
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1 Diabetes
Closed Loop From Onset in Type 1 Diabetes
The purpose of the study is to use a novel treatment approach, the artificial pancreas, after diagnosis of type 1 diabetes (T1D) to improve glucose control with the anticipated improvements of residual C-peptide secretion.
- Trial name
- CLOuD (NCT02871089)
- Testing
- Closed-loop system (Florence M or CamAPS FX), Multiple Daily Injections
- Where
- 7 sites in United Kingdom
- Volunteers
- 96 people
- Sponsor
- University of Cambridge
Type 2 Diabetes Mellitus
Effect of Intensive Therapy Associated With CSII on β-cell Function With Newly Diagnosed Type 2 Diabetes
The purpose of this study is to investigate and evaluate the effects of different interventions (1.continuous subcutaneous insulin infusion,2.continuous subcutaneous insulin infusion combined with rosiglitazone 3.continuous…
- Trial name
- NCT00948324
- Testing
- CSII,ALA,MET,RSG
- Volunteers
- 400 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Type I
The Effectiveness of Continuous Glucose Monitoring in Diabetes Treatment for Infants and Young Children
The purpose of this study is to see if the use of a real-time glucose sensor improves diabetes control in young children (less than 4 years old) with Type I diabetes when they are initiated on insulin pump therapy.
- Trial name
- Gerber RTSA (NCT00875290)
- Testing
- Real-time glucose sensor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
Automated Closed-loop in Children and Adolescents With Type 1 Diabetes
People with type 1 diabetes need regular insulin injections or continuous delivery of insulin using a pump. Keeping blood sugars in the normal range is known to reduce long term complications.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam09 (NCT02129868)
- Testing
- Closed-loop (Android Closed-Loop platform)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Cambridge
Type 1 Diabetes Mellitus
Pediatric Diabetics Type 1 Using InsuPatch
This study is a prospective, single-center, open label, randomized; two-arms cross over study. This is the test protocol for the InsuPatch device, whose purpose is to improve insulin delivery into the blood when the insulin is…
- Trial name
- NCT01368978
- Testing
- InsuPatch
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Insuline Medical Ltd.
Diabetes Mellitus, Type 2
Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes
The purpose of this study is to compare the blood glucose control, glycaemic fluctuation and oxidative stress for Type 2 Diabetes between two therapies, one is glargine combined with oral drugs and the other is continuous…
- Trial name
- COGFOST (NCT02526810)
- Testing
- insulin lispro, Insulin Glargine
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type1 Diabetes
Effect of Dual-wave Insulin Bolus on Postprandial Glycaemia
A study was conducted in adolescents with type 1 diabetes (T1D) examining the effect of different bolus types on 6-h postprandial glucose levels after the consumption of 3 standard meals with varying composition.
- Trial name
- NCT03179280
- Testing
- insulin
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 2 Diabetes Mellitus
Safety and Efficacy Study of Insulin Lispro Versus Insulin Aspart in Participants With Type 2 Diabetes on Insulin Pump Therapy
This study will provide information on the use of insulin lispro and insulin aspart in insulin pumps in participants with type 2 diabetes.
- Trial name
- NCT01474538
- Testing
- Insulin Lispro, Insulin Aspart
- Where
- 12 sites in United States
- Volunteers
- 122 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Pharmacokinetics/Dynamics of Basal (Continuous) Insulin Infusion Administered Either Intradermally or Subcutaneously
The primary objective of this study will be to assess the PK/PD responsiveness of basal ID administered insulin compared to SC, and to determine the safety and local tolerability of extended (two six-hour periods) microneedle…
- Trial name
- NCT01061216
- Testing
- Intradermal insulin delivery: BD Research Catheter Set, Subcutaneous insulin delivery:ACCU-CHEK Rapid-D Infusion Set
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Becton, Dickinson and Company
Diabetes
TReatment by Insulin Continuous Infusion in Type 2 DIAbetes
The aim of the TRICIDIA2 study is to compare two modalities of administration of insulin. In our future study, the investigators wish to study if the treatment by continuous infusion of insulin improves the insulinosensitivity of…
- Trial name
- TRICIDIA2 (NCT01889914)
- Testing
- 2 different procedures of administration of insulin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Quality of Life, Burden, Dependency
Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life
The use by diabetes patients of real-time Continuous Glucose Monitoring (CGM) system is becoming widespread and has changed diabetic practice. Automated closed-loop (CL) insulin therapy has come of age.
- Trial name
- IMPLIQUE (NCT04939766)
- Testing
- Activation of a closed loop device in an insulin pump device with GCM
- Volunteers
- 250 people
- Sponsor
- VitalAire
Type 1 Diabetes Mellitus
Efficacy of Continuous Glucose Monitoring in Subjects With Type 1 Diabetes Mellitus on Multiple Daily Injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) Therapy
The purpose of this study is to evaluate the effectiveness of the Continuous Glucose Monitoring System (DexCom™ SEVEN PLUS®) and to evaluate the impact of CGM on glycemic control when worn for up to 6-months by subjects 18 to 70…
- Trial name
- NCT01104142
- Testing
- CGM
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- DexCom, Inc.
Type 1 Diabetes Mellitus
A Study Comparing LY900014 to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes Using Insulin Pump Therapy
The reason for this study is to compare the study drug LY900014 to insulin lispro (Humalog) when both are used in insulin pump therapy in adults with type 1 diabetes (T1D).
- Trial name
- PRONTO-Pump-2 (NCT03830281)
- Testing
- Ultra-Rapid Lispro, Insulin Lispro
- Where
- 83 sites in United States, Australia and 9 more
- Volunteers
- 471 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Randomized, Double-blind, Crossover, Pharmacokinetic (PK) and Glucodynamic (GD) Study of Continuous Subcutaneous Insulin Infusion (CSII) in Participants With Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to determine if recombinant human hyaluronidase PH20 (rHuPH20) will change the exposure and action of approved insulin analogs when given by continuous subcutaneous insulin infusion (CSII) in…
- Trial name
- NCT01275131
- Testing
- Insulin aspart, Recombinant human hyaluronidase PH20 (rHuPH20)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Halozyme Therapeutics
Insulin Resistance, Endothelial Dysfunction
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance
The hypothesis is that GHRP-3 will exert beneficial effects on endothelial function and insulin resistance in older men and women via hormonal (GH, IGF-I, IGFBP-3,-1, insulin) and non-hormonal actions (anti-inflammatory).
- Trial name
- NCT00846872
- Testing
- GHRP-3 low dose, GHRP-3 high dose, Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Type 1 Diabetes
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
This research is being done to better understand how insulin effects muscle, blood, and the body in people with Type 1 Diabetes.
- Trial name
- NCT05985135
- Testing
- Muscle Biopsy, Jell-O with Amino acids, Dextrose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic