Clinical trials: Contact Lens Care
Contact Lens Moisture
Effect of an Investigational Multi-Purpose Solution on Lens Moisture
The purpose of the study is to evaluate the effect of an investigational multi-purpose disinfecting solution (MPDS) compared to a marketed multi-purpose solution on the moisture of silicone hydrogel contact lenses.
- Trial name
- NCT01341990
- Testing
- FID 114675A Multi-Purpose Disinfecting Solution (MPDS), ReNu Fresh Lens Comfort Multi-Purpose Solution (MPS), Silicone Hydrogel Contact Lenses
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Alcon Research
Corneal Epithelial Disruption, Corneal Staining
Evaluation of Corneal Staining With Various Contact Lens/Solution Combinations
The purpose of this study is to quantify the amount of corneal staining observed with various marketed contact lens/multipurpose solution combinations.
- Trial name
- NCT00381446
- Testing
- Marketed contact lens care products
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Andrasko, Gary, OD, LLC
Myopia, Astigmatism
Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers
The purpose of this study was to assess the comfort of OPTI-FREE RepleniSH in soft contact lens wearers.
- Conditions
- Myopia, Astigmatism, Refractive Error
- Trial name
- NCT01211535
- Testing
- OPTI-FREE RepleniSH multipurpose solution, ReNu Biotrue multipurpose solution, Silicone hydrogel contact lenses
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Alcon Research
Corneal Staining
Assessment of Tear Film-Based Proteins Associated With Care Solution Induced Corneal Staining
The purpose of this study was to investigate the association of inflammatory mediators found in the tear film during the development and following the induction of contact lens solution-induced corneal staining.
- Trial name
- NCT01100424
- Testing
- Opti-Free RepleniSH, ReNu MultiPlus, Balafilcon A
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Contact Lens Care
AOSEPT (CLEAR CARE) PLUS Study
The purpose of this post-market clinical follow-up (PMCF) study is to evaluate the long-term safety and performance of 2 commercially available contact lens cleaning and disinfecting systems in a pediatric population.
- Trial name
- NCT06588400
- Testing
- AOSEPT Plus and AOCup lens case, AOSEPT Plus with HydraGlyde and AOCup lens case, Habitual contact lenses
- Where
- United States
- Sponsor
- Alcon Research
Myopia, Refractive Error
Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface
The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.
- Trial name
- NCT01250925
- Testing
- ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
- Where
- 2 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Contact Lens and Punctal Plug in Preventing Corneal Injuries
A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries
Study Rationale: The insertion of a bandage contact lens or punctal plug in a defined group of patients admitted to the ICU may be more effective than standard care in decreasing the incidence of corneal injuries.
- Trial name
- COMLENPLSTAN (NCT01961193)
- Testing
- contact lens, punctal plug
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Rabin Medical Center
Contact Lens Care
OPTI-FREE Family STUDY
The purpose of this post-market clinical follow-up (PMCF) study is to evaluate the long-term safety and performance of 3 commercially available contact lens cleaning and disinfecting solutions in a pediatric population.
- Trial name
- NCT06592521
- Testing
- OPTI-FREE EXPRESS MPDS and Alcon contact lens case, OPTI-FREE PureMoist MPDS and Alcon contact lens case, OPTI-FREE REPLENISH MPDS and Alcon contact lens case
- Where
- United States
- Sponsor
- Alcon Research
Presbyopia
CLEAR CARE® PLUS for Presbyopic Contact Lens Wearers
The purpose of this study is to evaluate CLEAR CARE® PLUS (CCP) compared to non-HYDRAGLYDE® multi-purpose contact lens solutions in presbyopes currently wearing soft contact lenses and experiencing symptoms of dryness.
- Trial name
- NCT02965833
- Testing
- 3% hydrogen peroxide solution with HydraGlyde® Moisture Matrix, Habitual Multi-Purpose Contact Lens Solution, Habitual Contact Lenses
- Volunteers
- 126 people
- Sponsor
- Alcon, a Novartis Company
Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye
Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease
The goal of this research is to determine if the Tangible Boost system adequately replenishes the Hydra-PEG coating on the surface of a rigid contact lens.
- Conditions
- Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye, Sjogren's Syndrome, Dry Eye
- Trial name
- NCT04313725
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Tangible Science
Myopia
Study Intended to Evaluate the Safety and Effectiveness of a Johnson & Johnson Vision Care Inc, (JJVCI) Contact Lens for Use on an Extended-wear Basis for up to 7 Days (6 Nights).
Study in the US intended to evaluate the safety and effectiveness of a Johnson \& Johnson Vision Care Inc, (JJVCI) contact lens for use on an extended-wear basis for up to 7 days (6 nights).
- Trial name
- NCT00241280
- Testing
- etafilcon A, galyfilcon A
- Where
- 25 sites in United States
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia
An Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues
The purpose of this study was to assess and compare the effect of the repeated usage of 2 different care systems (one hydrogen peroxide based cleaning and disinfecting system and one PHMB containing multipurpose system) with…
- Trial name
- ID11-56 (NCT01594294)
- Testing
- AOSEPT® Plus contact lens solution, ReNu MultiPlus® contact lens solution, Etafilcon A contact lenses
- Volunteers
- 100 people
- Sponsor
- Alcon Research
Contact Lens Care
Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues
The purpose of this study was to assess and compare the effect of the repeated usage of two different contact lens care systems (one hydrogen peroxide-based cleaning and disinfecting system, and one polyaminopropyl biguanide…
- Trial name
- NCT01494818
- Testing
- Hydrogen peroxide-based contact lens care system, PHMB-containing contact lens solution, Soft contact lenses
- Volunteers
- 79 people
- Sponsor
- Alcon Research
Symptomatic Contact Lens Wearers
Alcon Multi-Purpose Disinfecting Solution Versus Renu Fresh Multi-Purpose Solution in Symptomatic Contact Lens Wearers
The purpose of this study is to compare two contact lens care solutions in symptomatic wearers of silicone hydrogel contact lenses.
- Trial name
- NCT01187355
- Testing
- FID 114675A Multi-Purpose Disinfecting Solution (MPDS), renu fresh Multi-Purpose Solution (MPS), Contact lenses
- Where
- United States
- Volunteers
- 591 people
- Sponsor
- Alcon Research
Healthy Contact Lens Wearers
Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution
The purpose of this study is to determine if Alcon MPDS is safe and effective for silicone hydrogel and soft hydrogel contact lens wearers.
- Trial name
- NCT01341977
- Testing
- Alcon MPDS, ReNu Fresh MPS
- Where
- United States
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Contact Lens Care
Single Site Study of the Wettability of Contact Lenses With an Investigational Multi-Purpose Disinfecting Solution vs. a Marketed Multi-Purpose Solution
The purpose of this study is to clinically evaluate an investigational multi-purpose disinfecting solution (MPDS) compared to a commercial MPDS with respect to wettability of silicone hydrogel contact lenses.
- Trial name
- NCT00885092
- Testing
- FID 114675A Multi-Purpose Disinfecting Solution (MPDS), RepleniSH Multi-Purpose Disinfecting Solution (MPDS) (OPTI-FREE® RepleniSH®), Senofilcon A contact lens (ACUVUE® Oasys™)
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Contact Lenses
A Clinical Comparison of Three Contact Lens Care Systems and Their Effect on Contact Lenses
The purpose of this study was to evaluate the clinical performance of three differing contact lens care solutions when used in conjunction with three contact lenses.
- Trial name
- NCT00982046
- Testing
- Opti-Free RepleniSH multi-purpose disinfecting solution, ReNu MultiPlus multi-purpose solution, Clear Care cleaning and disinfecting system
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Alcon Research
Contact Lens Care
Corneal Barrier Function With Multi-Purpose Solutions
The purpose of this study is to evaluate the effect on epithelial barrier function of three emarketed multi-purpose solution applied to the human eye with hydrogel lenses as during normal regimen use.
- Trial name
- NCT00407238
- Testing
- Multi-purpose solutions (polyquaternium-1 and PHMB)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Myopia
A Comparison of Two Color Contact Lenses in Habitual Clear Contact Lens Wearers
The purpose of this study is to evaluate the comfort of color contact lenses in a population of clear contact lens wearers who have an interest in wearing color contact lenses.
- Trial name
- NCT02175199
- Testing
- Lotrafilcon B contact lenses with color printing, Phemfilcon A contact lenses with color printing
- Volunteers
- 151 people
- Sponsor
- Alcon Research
Contact Lens Care
Effect of Multi-Purpose Solutions on Ex-Vivo Wetting Angles
To clinically evaluate the effect of a new multi-purpose disinfecting solution compared to a marketed multi-purpose solution on wettability of soft contact lenses worn for 30 days.
- Trial name
- NCT00383201
- Testing
- OptiFree Multi-Purpose Disinfecting Solution
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alcon Research