Clinical trials: Constriction, Pathologic
Coronary Artery Disease, Stable Angina
Investigation of the Role of Hemodynamics in Re-stenosis of CABG Patients
CFD simulations in this study provide detailed hemodynamics information, which cannot be obtained from cardiac images alone. The investigators hypothesize that our proposed simulations will provide strong correlation between…
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- NCT02791087
- Testing
- Computed Tomography Angiography, Intra-operative graft flow rate measurement
- Where
- Singapore
- Volunteers
- 54 people
- Sponsor
- National Heart Centre Singapore
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Acute Coronary Syndrome With ST Elevation on Electrocardiogram, Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Tryptase and Coronary Heart Disease
The main aim of this study will evaluate differences in serum levels of tryptase in study population. Will be selected a number of 350 patients hospitalized for coronary heart disease.
- Conditions
- Acute Coronary Syndrome With ST Elevation on Electrocardiogram, Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Noncritical Coronary Artery Disease Coronary Stenosis Less Than 50 Per Cent, Aortic Aneurysms
- Trial name
- NCT01618279
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Niguarda Hospital
Chronic Obstructive Pulmonary Disease
Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing
This study is aimed to determine factors leading to obstructive granulation tissue formation after placement of Self-Expandable Metallic Stent (SEMS) in patients with benign tracheal diseases.
- Trial name
- NCT01006200
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
IIH - Idiopathic Intracranial Hypertension
IIH Intervention: A Clinical Trial Comparing 2 Treatments (Shunts and Stents) Evaluation Of Clinical Effectiveness And Cost Effectiveness
Background and study aims Idiopathic intracranial hypertension (IIH) is a neurological condition characterised by increased pressure inside the skull, called intracranial pressure (ICP).
- Trial name
- Intervention (NCT07440277)
- Testing
- CSF shunt, DVSS
- Where
- 15 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Birmingham
Carotid Artery Disease
Frequency Analysis of Carotid Artery Disease
The purpose of this study is to determine if carotid artery stenosis can be detected using an electronic stethoscope. This study will use a commercially available electronic stethoscope to record carotid sounds in patients with…
- Trial name
- NCT01042912
- Where
- United States
- Sponsor
- University of Minnesota
Brain Diseases, Ischemic Stroke
Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis
IRIS-sICAS is a multicenter, randomized, double-blind, placebo-controlled clinical trialis a multicenter, randomized, double-blind, placebo-controlled clinical trial, to assess the safety and efficacy of tocilizumab injection in…
- Conditions
- Brain Diseases, Ischemic Stroke, Ischemia, Stroke
- Trial name
- IRIS-sICAS (NCT06447701)
- Testing
- Tocilizumab, NaCl 0.9% 100ml
- Volunteers
- 486 people
- Sponsor
- Zhujiang Hospital
Tracheobronchomalacia, Tracheal Stenosis
Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis
It is not clearly understood what causes tracheobronchomalacia (weakening of the windpipe and airways) or tracheal stenosis (narrowing of the windpipe).
- Trial name
- NCT00705848
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Adult Spinal Deformity, Degenerative Scoliosis
Gait and Paraspinal sEMG in Degenerative Spinal Diseases
This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal…
- Conditions
- Adult Spinal Deformity, Degenerative Scoliosis, Sagittal Deformity, Sagittal Imbalance
- Trial name
- TDGKSEPDSD (NCT07309926)
- Testing
- Gait analysis and surface electromyography analysis
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Application of 3D Printing Guide Plate in Endoscopic Spinal Surgery
Application of 3D printing guide plate in endoscopic spinal surgery
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Radicular Pain, Low Back Pain
- Trial name
- NCT05632835
- Testing
- 3D printing guide plate, Conventional guidance
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Peking University Third Hospital
Biliary Stricture, Biliary Tract Diseases
Percutaneous Biodegradable Biliary Stents for the Treatment of Benign Biliary Strictures.
To assess safety and effectiveness in the long term of percutaneous insertion of Biodegradable (BD) Biliary Stents for the treatment of benign biliary strictures, in a single center experience.
- Conditions
- Biliary Stricture, Biliary Tract Diseases, Bile Duct Stricture, Bile Duct Injury
- Trial name
- NCT05556668
- Testing
- Percutaneous placement of biodegradable biliary stents
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli
Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI)
Non-stenting Treatment Strategy for Acute Myocardial Infarction With Non-severe Stenosis(EROSION IV)
This study is a prospective, multicenter, open-label, non-inferiority, randomized controlled trial. A total of 2,000 patients with STEMI (<24 hours or 7-14 days) or NSTEMI will be recruited from at least 20 centers in China.
- Conditions
- Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction(NSTEMI)
- Trial name
- NCT07567625
- Testing
- Guideline-recommended standard medical therapy alone, DES implantation plus guideline-recommended standard medical therapy
- Where
- 48 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Harbin Medical University
Coronary Artery Disease, Coronary Artery Disease Progression
Disease Characteristics of R-CAD
The present case-control study is designed to investigate the disease characteristics of rapidly progressive coronary artery disease (R-CAD) by comparing the demographics, clinical features, lab results, imaging findings, and…
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Stenosis, Coronary Restenosis
- Trial name
- NCT07239921
- Testing
- Protocol-defined Examinations and Evaluations
- Volunteers
- 52 people
- Sponsor
- Peking Union Medical College Hospital
Stroke, Transient Ischemic Attack
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of stent implantation in patients with symptomatic extra- and intracranial artery stenosis and to determine its role in secondary prevention of ischemic stroke.
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Stenosis
- Trial name
- ESSCAS (NCT00691314)
- Testing
- Stent implantation (Wingspan, Coroflex, and TiTAN2), Standard medical treatment
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Renal Artery Obstruction, Hypertension, Renovascular
Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery
This was a Phase 2a prospective, single center, randomized, double-blind, placebo-controlled study designed to assess the efficacy, pharmacokinetics, safety and tolerability of IV elamipretide for reduction of reperfusion injury…
- Conditions
- Renal Artery Obstruction, Hypertension, Renovascular, Ischemia Reperfusion Injury
- Trial name
- EVOLVE (NCT01755858)
- Testing
- Bendavia
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stealth BioTherapeutics Inc.
Advanced Gastric Carcinoma
Prospective Study on Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers
The purpose of this study is to explore the clinical application value of Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers.
- Trial name
- NCT05545293
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Biliary Obstruction, Oddi's Sphincter Constriction
clınıcal Effects of High-flow Nasal Oxygen Use ın gerıatrıc patıents
It is designed to monitor the efficacy of nasal cannula or hıgh-flow nasal oxygen in geriatric patients for endoscopıc retrograde cholangıopancreatography procedures.
- Conditions
- Biliary Obstruction, Oddi's Sphincter Constriction, Biliary Stones
- Trial name
- HFNO (NCT05432661)
- Testing
- HİGH-FLOW NASAL OXYGEN USE (HFNO)
- Volunteers
- 120 people
- Sponsor
- Yunus Emre
Williams Syndrome, Supravalvular Aortic Stenosis
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank
Williams syndrome is a rare genetic disorder occurring in 1:8000-12,000 individuals. It is caused by the deletion of 25-27 coding genes, including elastin (ELN) on the 7th human chromosome.
- Conditions
- Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
- Trial name
- NCT02706639
- Where
- 3 sites in United States
- Volunteers
- 305 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stenosis
Natural History of Asymptomatic Superior Mesenteric Arterial Stenosis.
The aim of this study was to evaluate asymptomatic superior mesenteric artery (SMA) stenosis prognosis according to the presence of coeliac artery (CA) and/or inferior mesenteric artery (IMA) associated stenosis.
- Trial name
- NCT04785105
- Testing
- No intervention
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Hospices Civils de Lyon