Clinical trials: Constipation - Functional
Constipation - Functional
Lubiprostone in Children With Functional Constipation
Study to determine if children (6-17 years old) with functional constipation will respond to being treated with lubiprostone for 12 weeks.
- Trial name
- NCT02042183
- Testing
- Lubiprostone
- Where
- 117 sites in United States, Belgium and 5 more
- Volunteers
- 606 people
- Sponsor
- Sucampo Pharma Americas, LLC
Constipation
Bowel Function After Minimally Invasive Hysterectomy
Postoperative constipation affects up to a third of women undergoing minimally invasive (MIS) gynecologic surgery and is a major source of anxiety and discomfort.
- Trial name
- NCT04263896
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Constipation
Lcr35 for Children With Functional Constipation
The aim of this study is to assess the effectiveness of Lactobacillus casei rhamnosus Lcr35 administration for the treatment of functional constipation in children.
- Trial name
- NCT01985867
- Testing
- Lactobacillus casei rhamnosus Lcr35
- Where
- Poland
- Volunteers
- 94 people
- Sponsor
- Medical University of Warsaw
Constipation-Predominant Irritable Bowel Syndrome
Randomized Trial of Mosapride Versus Placebo in the Treatment of Constipation-Predominant Irritable Bowel Syndrome
The purpose of this study is to determine whether Mosapride, an agent which acts on serotonin receptors in the gastrointestinal tract, is effective in the treatment of constipation-predominant irritable bowel syndrome (C-IBS).
- Trial name
- NCT00742872
- Testing
- Mosapride Citrate
- Where
- Lebanon
- Volunteers
- 41 people
- Sponsor
- American University of Beirut Medical Center
Irritable Bowel Syndrome
Study of LX1031 in Subjects With Non-Constipating Irritable Bowel Syndrome
The purpose of the study is to evaluate the safety, tolerability, and effectiveness of LX1031 versus a placebo control in subjects with non-constipating irritable bowel syndrome.
- Trial name
- NCT00813098
- Testing
- LX1031 High Dose, LX1031 Low Dose
- Where
- 36 sites in United States
- Volunteers
- 155 people
- Sponsor
- Lexicon Pharmaceuticals
Constipation
Prunes for Gastrointestinal Function After Gynecologic Surgery
This is a prospective, randomized control trial that randomizes patients post-operatively into standard care versus standard care plus prunes.
- Trial name
- NCT03523715
- Testing
- Prunes, Docusate Sodium
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Southern California
Chronic Constipation
Physiotherapeutic Intervention in Children With Chronic Functional Constipation
The purpose of this study is to determine whether physiotherapy is effective in the treatment of the chronic functional constipation in children.
- Trial name
- NCT00906971
- Testing
- diaphragmatic breathing, isometric training of the abdominal muscles and abdominal massage
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Universidade Federal de Pernambuco
Irritable Bowel Syndrome With Constipation
Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
The purpose of this study is to determine the safety, efficacy, and dose response of a range of oral doses of linaclotide administered to patients meeting criteria for IBS-C.
- Trial name
- NCT00460811
- Testing
- Linaclotide Acetate
- Where
- 85 sites in United States, Canada
- Volunteers
- 420 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Joint Diseases, Arthritis
A Study to Compare the Frequency of Constipation Symptoms With Tapentadol Immediate Release (IR) Treatment Versus Oxycodone IR Treatment in Patients With End-stage Joint Disease
The purpose of this study is to compare bowel function/constipation that occurs during tapentadol treatment with that occuring during oxycodone treatment, as measured by the frequency of spontaneous bowel movements per week.
- Conditions
- Joint Diseases, Arthritis, Osteoarthritis
- Trial name
- NCT00784277
- Testing
- oxycodone CR, oxycodone IR, Tapentadol ER (CG5503)
- Volunteers
- 597 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Spinal Cord Injury, Constipation
Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI
An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels.
- Conditions
- Spinal Cord Injury, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT02406859
- Testing
- Bowel Biofeedback, Anorectal Manometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Constipation
Effects of Exercise Training on Pelvic Floor Symptoms and Function in Adults With Constipation
Constipation is a common problem in the general population. Defecation disorders caused by abnormal contraction or insufficient relaxation of the pelvic floor muscles during defecation may be one of the most possible causes of…
- Trial name
- NCT04661202
- Testing
- multimodal exercise training
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- National Cheng Kung University
Constipation
Effects of Alpha-1 Antagonist, Stress and Relaxation on Anorectal Functions
This study is designed to better understand the effects of effects of stress, relaxation, and a medication alfuzosin on bowel control and emptying in healthy people and patients with bowel problems.
- Trial name
- NCT01834729
- Testing
- Alfuzosin
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Idiopathic Constipation
SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation
This is a Phase 2a, randomized, double-blind, placebo-controlled, 14-day repeat oral, dose ranging study to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) effects of SP-304 in patients with chronic…
- Trial name
- CIC (NCT01053962)
- Testing
- SP-304 0.3 mg, SP-304 1.0 mg, SP-304 3.0 mg
- Where
- 14 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bausch Health Americas, Inc.
Irritable Bowel Syndrome With Constipation
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation
The purpose of this study is to evaluate the safety and efficacy of linaclotide for the treatment of Irritable Bowel syndrome with Constipation (IBS-C), in children age 7-17 years.
- Trial name
- LIN-MD-63 (NCT02559817)
- Testing
- Linaclotide Dose A, Linaclotide Dose B, Linaclotide Dose C
- Where
- 48 sites in United States, Canada
- Volunteers
- 101 people
- Sponsor
- Forest Laboratories
Functional Constipation
Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation
This is a single-center, randomized, parallel group, double-blind, placebo-controlled, dose response, pharmacodynamic and pharmacokinetic study evaluating the effects of A3309 on gastric, intestinal and colonic transit in…
- Trial name
- NCT01038687
- Testing
- A3309
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Michael Camilleri, MD
Constipation
A Dose Determination Study of Chinese Herbal Medicine for Functional Constipation
Functional constipation (FC) is common with 14.3% estimated prevalence in Hong Kong, but treatment for this condition in conventional medicine is suboptimal.
- Trial name
- NCT00299975
- Testing
- MaZiRenWan (MZRW) Low dose, MaZiRenWan (MZRW) Median dose, MaZiRenWan (MZRW) High dose
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Hong Kong Baptist University
Constipation
B. Lactis HN019 for Functional Constipation
This study will investigate the effects of 4-week probiotic supplementation on whole gut transit time and gastrointestinal symptoms in adults with functional constipation.
- Trial name
- CTT (NCT01463293)
- Testing
- B. lactis HN019
- Where
- 12 sites in United States
- Volunteers
- 224 people
- Sponsor
- Fonterra Research Centre
Functional Constipation in Children Ages 6-17 Years
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)
The purpose of this study was to evaluate dose response of the safety and efficacy of linaclotide for the treatment of functional constipation (FC), in children age 6-17 years.
- Trial name
- NCT02559570
- Testing
- LIN Dose A, LIN Dose B, LIN Dose C
- Where
- 62 sites in United States, Canada
- Volunteers
- 173 people
- Sponsor
- Forest Laboratories
Constipation-predominant Irritable Bowel Syndrome
Cheno Effect on Transit in Health and IBS-C
The study hypothesis is that the naturally occurring bile acid, chenodeoxycholic acid, induces acceleration of colonic transit in health and in patients with constipation-predominant Irritable Bowel Syndrome (IBS-C).
- Trial name
- Chenotransit (NCT00912301)
- Testing
- Sodium chenodeoxycholate (NaCDC)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Constipation, Fecal Incontinence
A Colonic Tube to Improve Bowel Function in Spinal Cord Injury
The investigators want to know if placing a tube through the skin and into the colon to flush out the colon is safe and effective in helping spinal cord Veterans with bowel management.
- Conditions
- Constipation, Fecal Incontinence, Spinal Cord Injury
- Trial name
- NCT00345397
- Testing
- Percutaneous endoscopic colostomy (PEC) tube
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development