Clinical trials: Constipation
Constipation
Clinical Study of Resistant Starch in Improving Constipation
Constipation is one of the most common gastrointestinal (GI) disorders in clinical practice, with approximately 11-20% of adults worldwide suffering from constipation.
- Trial name
- NCT06292949
- Testing
- Resistant starch
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huaping Xie
Constipation, Constipation - Functional
The Effects of TTNS, TTNS Combined With PHUS, and Conventional Therapy With PHUS in the Treatment of PFC.
This study is a randomized, controlled trial designed to evaluate the effects of transcutaneous tibial nerve stimulation (TTNS), TTNS combined with pocket-sized handheld ultrasound (PHUS), and conventional therapy with PHUS on…
- Trial name
- constipation (NCT07077044)
- Testing
- The transcutaneous posterior tibial nerve stimulation device, PSUS
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Children, Only
Correlation Between Toilet Sitting Position, Ankle Range of Motion, and Lower Limb Strength in Children
This study investigates the relationship between different toilet sitting styles (squat vs. western) and their effects on ankle range of motion (ROM), constipation symptoms, and lower limb strength in school-going children aged…
- Trial name
- NCT07576491
- Where
- Pakistan
- Volunteers
- 191 people
- Sponsor
- Riphah International University
Constipation
A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
This research is studying how the availability of a Food and Drug Administration (FDA)-cleared point-of-care, bedside device bedside device called Rectal Expulsion Device (RED) can be used to evaluate constipation in the…
- Trial name
- NCT07032376
- Testing
- Survey, Rectal Expulsion Device use
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
Functional Constipation (FC)
Fiber Nutritional Supplement for Management of Constipation During Pregnancy
This study aims to evaluate the effectiveness of a daily Fiber Nutritional Supplement (Materna® Opti fiber), containing partially hydrolyzed guar gum (PHGG) and vitamins C, D, zinc, and selenium, combined with nutritional…
- Trial name
- NCT07588633
- Testing
- fiber supplement (PHGG) with counselling for constipation management
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Constipation - Functional
Cross-Cultural Adaptation, Validity, and Reliability of the Wexner Questionnaire in Patients With Constipation
The investigators will conduct a validity and reliability study of the Wexner Constipation Questionnaire, used for constipation, in Turkish.
- Trial name
- NCT07340203
- Testing
- survey
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Bowel Symptoms, Constipation
Final Examination Stress and Bowel Symptoms
This prospective observational study aims to investigate the association between final examination stress and bowel symptoms in university students.
- Conditions
- Bowel Symptoms, Constipation, Gastrointestinal Symptoms
- Trial name
- NCT07838259
- Testing
- Observational Assessment During the Final Examination Period
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Faecal Incontinence, Constipation - Functional
Peristeen Light Explorative Clinical Investigation
The goal of this exploratory clinical investigation is to understand the clinical benefits of Peristeen Light in adult patients with faecal incontinence, chronic constipation and/or time-consuming bowel management procedures.
- Trial name
- NCT07126327
- Testing
- Peristeen Light - trans anal irrigation system
- Where
- 2 sites in Denmark, Italy
- Volunteers
- 60 people
- Sponsor
- Coloplast A/S
Irritable Bowel Syndrome With Constipation (IBS-C)
Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years
This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety and tolerability of tenapanor (25 mg and 50 mg) in pediatric patients (≥12 and <18 years old) with IBS-C when administered twice daily…
- Trial name
- NCT05643534
- Testing
- Tenapanor 50 MG, Tenapanor 25 mg bid
- Where
- 39 sites in United States
- Volunteers
- 180 people
- Sponsor
- Ardelyx
Constipation, Surgical Procedure, Unspecified
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
The goal of this clinical trial is to test the use of a laxative before surgery in women having surgery to fix pelvic prolapse that do not have constipation.
- Conditions
- Constipation, Surgical Procedure, Unspecified, Prolapse; Female
- Trial name
- NCT06159777
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University Hospitals Cleveland Medical Center
Anxiety, Bowel Habits
Test Anxiety on Bowel Health and Constipation in Students
This observational cross-sectional study aims to examine the relationship between test anxiety, bowel health, and constipation in university students.
- Conditions
- Anxiety, Bowel Habits, Constipation
- Trial name
- NCT07654959
- Testing
- Observational assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Constipation, Chronic Constipation
Balloon Inflation in Biofeedback
Chronic constipation, particularly due to dyssynergic defecation, is common and impacts quality of life. Biofeedback therapy (BFT) is the most effective conservative treatment, teaching patients to coordinate abdominal and anal…
- Conditions
- Constipation, Chronic Constipation, Dyssynergia, Anismus
- Trial name
- NCT07705542
- Testing
- Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Irritable Bowel Syndrome With Constipation
Home Transcutaneous Electrical Acustimulation (TEA)
This study will assess the efficacy of two active treatments with TEA and a chemical neuromodulator (escitalopram aka Lexapro) versus a sham comparator or control group on abdominal pain.
- Trial name
- Home-TEA (NCT05519683)
- Testing
- TEA, Lexapro
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Michigan
Constipation
Investigation of the Additional Effects of Aerobic Exercise Training to Abdominal Massage in Functional Constipation
The aim of this study was to investigate the additional effects of aerobic exercise to abdominal massage in patients with functional constipation.
- Trial name
- NCT06298331
- Testing
- Aerobic Exercise, Abdominal Massage, Patient Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Autism Spectrum Disorder, Gastrointestinal Symptoms
Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder
This protocol is a blinded randomized controlled study of the effects of BB-12 with LGG at different doses in 70 healthy children with autism spectrum disorders at lower and higher doses over an 56-day period and a 28- day…
- Trial name
- NCT03514784
- Testing
- BB-12 with LGG (Higher Dose), BB-12 with LGG (Lower Dose)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Constipation
Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
The study is being completed to test the pilot implementation of a rapid clinical care pathway for chronic constipation in the University of Michigan Gastroenterology clinic.
- Trial name
- NCT06352827
- Testing
- Survey
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Michigan
Refractory Constipation, Somatic Symptom Disorder (DSM-5)
Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features
This single-center, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of fluoxetine (40 mg/day) versus placebo in 194 adults with refractory chronic constipation exhibiting Somatic Symptom…
- Conditions
- Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)
- Trial name
- REFLECT (NCT06506136)
- Testing
- Fluoxetine
- Volunteers
- 194 people
- Sponsor
- Zhifeng Zhao, PhD
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital