Clinical trials: Consolidation Therapy
Stroke, Aging
Enhancing Sleep Dependent Consolidation by Non-invasive Brain Stimulation
Stroke, one of the most common causes for acquired adult disability, is not only a burden for the individual but also for his or her close relatives and caregivers.
- Trial name
- E-ConS (NCT05843656)
- Testing
- Non-invasive brain stimulation
- Where
- Switzerland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Friedhelm Hummel
Sleep, Consolidation
Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study
Memory benefits from sleep and these benefits are putatively achieved through reactivation of the neural memory trace during sleep.
- Trial name
- NCT04702724
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Multiple Sclerosis
Consolidation & Interference in Multiple Sclerosis
The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.
- Trial name
- NCT02081508
- Testing
- Interference onset
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Rectal Neoplasms
Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer
Given the growing focus on preserving organ function and the utilization of neoadjuvant therapy, it is important to investigate and enhance the application of comprehensive neoadjuvant therapy in low rectal cancer.
- Trial name
- NCT06417476
- Testing
- Short-course radiotherapy, Irinotecan, Oxaliplatin
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Pei-Rong Ding
Sleep
The Effect of tDCS Applied During Sleep on Memory Consolidation
This study will attempt to use a type of non-invasive brain stimulation technology during sleep to improve measures of sleep quality and memory in young healthy students and older adults.
- Trial name
- NCT02596568
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Learning, Humans
Human Learning of New Structured Information Across Time and Sleep
Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use.
- Conditions
- Learning, Humans, Consolidation, Sleep
- Trial name
- NCT05910762
- Testing
- Associative inference, Category learning, Sleep
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Sleep, Memory
Hypnotic Medications and Memory: Effect of Drug Exposure During the Night
The purpose of this study is to determine the effect of two hypnotic medications, zolpidem extended release and zaleplon, on memory.
- Trial name
- NCT01159652
- Testing
- zaleplon, zolpidem extended release
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Sleep Architecture, Cognitive Function
The Impact of Glycemic Index on Sleep and Memory Consolidation
The study will test whether the consumption of a low versus a high glycemic index pre-bed drink influences sleep architecture, memory consolidation, nocturnal glucose metabolism, and mood.
- Conditions
- Sleep Architecture, Cognitive Function, Mood, Glucose Metabolism
- Trial name
- NCT05591573
- Testing
- Low glycemic index drink, High glycemic index drink
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swansea University
Sleep
Modulation of Memory Consolidation in Humans
The goal of the present study is to optimize effects of slow oscillatory transcranial direct current stimulation (so-tDCS) on sleep physiology and memory consolidation in humans by combining computational and experimental human…
- Trial name
- NCT04714879
- Testing
- Device: anodal tDCS, Device: no stimulation
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Sleep
Implications of Anesthetics on Sleep Consolidation
Sleep leads to consolidation of learning in humans, restoring memories that were forgotten over a waking day and protecting memories against future forgetting.
- Trial name
- NCT04329091
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Language Development Disorders
Perceptual Learning and Memory Consolidation in Adults With and Without LI
This study tests a memory-based account of atypical speech perception in adults with language-based learning disability (also known as developmental language impairment [LI]).
- Trial name
- NCT03609502
- Testing
- behavioral training
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Parkinson Disease, Aging
Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults
People with Parkinson's disease (pwPD) often present difficulty consolidating newly learned skills into long-term memory. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted…
- Trial name
- TARGET-SLEEP (NCT04144283)
- Testing
- NAP, WAKE
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Sleep
Effects of WiFi Exposure on Sleep in Women
Effects of Wifi exposure on sleep and sleep-related memory consolidation are investigated in a double-blind, sham-controlled fully counterbalanced study design in young healthy women.
- Trial name
- NCT04583397
- Testing
- radio frequency electromagnetic fields
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Pain, Acute, Motor Activity
Effects of Acute Pain vs Context Change on Motor Learning Retention in Young Adults
To date, the effects of pain on motor learning have not been thoroughly investigated. When examining potential effects on retention of motor learning, it is important to dissociate any effects of pain from effects of a context…
- Trial name
- NCT05626582
- Testing
- pain delivery - learning only, pain delivery - learning and retention
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Intrusive Memories
Behavioral Modulation of Intrusive Memories
The purpose of the study is to examine whether sleep affects the development of intrusive memories.
- Trial name
- NCT03227081
- Testing
- Sleep Deprivation
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Elderly Subjects
Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Elderly Healthy Subjects
The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent…
- Trial name
- NCT01791790
- Testing
- Stimulation
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Attention Deficit Disorder With Hyperactivity
Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.
Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram.
- Trial name
- HYPNOS (NCT05876286)
- Testing
- Neurological examinations
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Intrusive Memories, PTSD
The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03875391
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany