Clinical trials: Consciousness Disorders
TBI (Traumatic Brain Injury)
Clinical Significance of circMETTL9 Gene in Traumatic Brain Injury
Objective: The relevance of circMETTL9 to the degree of injury, disturbance of consciousness, cognitive function and prognosis in patients with moderate to severe traumatic brain injury (TBI) remains unknown.
- Trial name
- NCT05484921
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Low Mood, Depressive Symptoms
The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood
A randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of 8 weeks of supplementation with Bifidobacterium longum 1714® strain on Beck's Depression Inventory-II Score in adults who experience low mood.
- Trial name
- NCT04925440
- Testing
- Bifidobacterium longum 1714® strain
- Where
- Ireland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- PrecisionBiotics Group Ltd.
Consciousness Disorders
Micro-movements in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness.
- Trial name
- NCT06406413
- Testing
- micro-movement; electroencephalogram; MRI
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Craniocerebral Trauma, Traumatic Brain Injury
Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury.
The aim of this study is to determine whether passive gait training increases arousal, demonstrated as changes in EEG (electroencephalogram) activity.
- Conditions
- Craniocerebral Trauma, Traumatic Brain Injury, "Rehabilitation"
- Trial name
- NCT00430703
- Testing
- body weight support treadmill training
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Locked- in Syndrome
A Method for Communication With Arabic Patients Suffering From Classic Locked- in Syndrome
Aim of the work The aim of this study is to test an Arabic alphabet communication system designed to train physicians to communicate with Arabic-speaking patients with LIS.
- Trial name
- NCT05444075
- Testing
- a method for communication
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Unconscious State
The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery
213 patients undergoing elective on-pump coronary artery bypass grafting (CABG) were enrolled into this prospective-clinical trial.After hundred and sixty three patients were excluded due to various reasons, 50 patients were…
- Trial name
- NCT02520947
- Testing
- BIS, Desflurane
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Lesional Coma
Imaging of the Neural Correlates of Arousal and Awareness
In last decades, several advances in the neuro-intensive management have lead to decrease mortality in Intensive Care Units. A significant morbidity remains as patients survive after a traumatic coma with uncertain quality of…
- Trial name
- IMAGINA (NCT04575454)
- Testing
- Multimodal evaluation of brain function : PET-MRI, electrophysiology, eye-tracking
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Disorders of Consciousness, Psychedelic Experiences
The Effects of Psilocybin on Shared Experience in Film Processing
The goal of this clinical trial is to learn whether certain methods of detecting awareness in vegetative or minimally conscious patients (using neuroimaging) are sensitive to the effects of psilocybin (a psychedelic drug).
- Trial name
- NCT06529939
- Testing
- Psilocybin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Nurse's Role, Nurse-Patient Relations
Effect of Virtual Reality Simulation on Nursing Students' Knowledge and Skill Performance in Respiratory Physical Examination
Aim To compare the effects of immersive virtual reality (I-VR) and peer-assisted small-group practice on nursing students' knowledge, skill performance, and performance time in respiratory system physical examination.
- Conditions
- Nurse's Role, Nurse-Patient Relations, Exanimation
- Trial name
- NCT06536361
- Testing
- Virtual Reality-Based Learning Tool, Traditional Small Group Training
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gazi University
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Consciousness Disorder, Brain Injuries
Neurovascular Reactions to AAT in Patients With DOC
There is practical evidence but no scientific investigations that persons with severe disorders of consciousness can profit from animal-assisted therapy regarding their level of awareness.
- Trial name
- AAT NIRS (NCT03341325)
- Testing
- animal-assisted activity, control activity
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Disorder of Consciousness
Olfactory Stimulation in Severe Brain Injury
The management of patients with disorders of consciousness (DoC) represents a topic of great importance and topicality in the medical-scientific field because of the complexity and extent of associated disabilities and the…
- Trial name
- NCT05747170
- Testing
- Olfactory sstimulation
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Asthma, Syncope
Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death
The investigators' hypothesis is that dysregulation of autonomic function, as revealed during a simulated dive reflex, may result in an attenuation of the heart rate response to a greater degree in asthmatics who collapse during…
- Trial name
- NCT02083029
- Testing
- Simulated dive reflex
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Dental Caries, Tooth Extraction
Treating Children With Extensive Dental Needs
The goal of this qualitative study, using Grounded Theory, is to gain deeper knowledge about dentists' experiences from treating in particular young children with an extensive treatment need (mainly due to caries).
- Conditions
- Dental Caries, Tooth Extraction, Conscious Sedation, Attitude
- Trial name
- NCT06863103
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Malmö University
Anorexia Nervosa
The Embodied Cognition: Exploratory Study of Automatic and Controlled Processes in Anorexia Nervosa.
Anorexia nervosa (AN) is a common psychiatric illness, with severe prognosis (5% mortality) that has changed little over in half a century. One of the forms is the restrictive anorexia nervosa (ANR).
- Trial name
- NCT02538796
- Testing
- TEA + Grober Test + Task 1 + Grober Test, TEA + Grober Test + Task 2 + Grober Test, TEA + Grober Test + Implicit Task 3 + Grober Test
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cataract
Conscious Sedation Efficacy of the MKO Melt (Midazolam, Ketamine, Ondansetron)
The investigators hypothesized that the combination of Valium, Tramadol and Zofran is superior to the substantially more expensive MKO melt in patient satisfaction after cataract surgery.
- Trial name
- NCT03653520
- Testing
- Diazepam, Tramadol, Ondansetron
- Where
- United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Avanti Anesthesia
Brain Death
Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation
The study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the University Hospital Basel, the…
- Trial name
- DISCOVER (NCT06640088)
- Where
- Switzerland
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique
Effects of Pranayama Breathing Technique on Stress Level, Sleep Quality, and Quality of Life Among Older Adults
Aging is associated with progressive tissue deterioration resulting from a continuous decline in the ability to renew homeostatic cell regeneration and replace cells lost during tissue damage.
- Conditions
- Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique, Individuals Without a Malignant Respiratory System Disease (Such as Bronchial and Lung Cancer), Individuals Without a Pathological Condition Affecting Their Level of Consciousness and Concentration
- Trial name
- NCT07451756
- Testing
- Pranayama group
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Cataract, Bilateral Senile Cataract
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
The goal of this pilot clinical trial comparing two different sedation approaches for cataract surgery is to assess the feasibility, completeness, and distribution of data in measuring patient satisfaction, the quality of…
- Conditions
- Cataract, Bilateral Senile Cataract, Anesthesia, Patient Satisfaction
- Trial name
- CaTNAPS-1 (NCT06506669)
- Testing
- Oral sedation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco