Clinical trials: Congenital Cataract
Fuchs' Endothelial Dystrophy, Cataract
Risk Assessment for Progression to DMEK Following Cataract Surgery in Fuchs Endothelial Corneal Dystrophy
Justification. Fuchs' corneal endothelial dystrophy (FECD) is one of the main causes of corneal transplantation. In many cases, the corneal decompensation derived from this dystrophy is triggered as a consequence of cataract…
- Trial name
- NCT04072029
- Testing
- Phacoemulsification with intraocular lens implantation
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Congenital Cataract Polar Posterior
Visual Function in Pediatric Patients With Posterior Lens Opacities
Prognostic factors determining visual outcomes in patients with posterior polar cataracts and posterior lenticonus are largely unknown.
- Trial name
- NCT05207007
- Testing
- Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Sun Yat-sen University
Childhood Cataract
Increased Risk of ADHD Among Children With Bilateral Congenital Cataracts
In this study, the investigators conducted a cross-sectional, face-to-face investigation to evaluate the behavioral and psychological disorders and the risk of ADHD among children with bilateral congenital cataracts using the…
- Trial name
- NCT03692728
- Testing
- Psychological and Behavioral Problems
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cataract, Glaucoma
Potential Research Participants for Future Studies of Inherited Eye Diseases
This study will evaluate potential candidates for future clinical research studies related to diagnosed or undiagnosed genetic eye disorders or diseases.
- Conditions
- Cataract, Glaucoma, Retinitis Pigmentosa, Macular Degeneration
- Trial name
- NCT00559234
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)
Inclusion Body Myositis, Sporadic, Inclusion Body Myopathy, Autosomal-recessive
Natural History in CCFDN and IBM Syndromes
So far, only limited data is available regarding the natural course in Congenital Cataract Facial Dysmorphism Neuropathy Syndrome (CCFDN) and sporadic and hereditary inclusion body myopathies (IBM).
- Conditions
- Inclusion Body Myositis, Sporadic, Inclusion Body Myopathy, Autosomal-recessive, Inclusion Body Myopathy, Autosomal-dominant, Congenital Cataracts, Facial Dysmorphism, And Neuropathy
- Trial name
- NCT01902940
- Testing
- Natural History
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cataract
A Novel Congenital Cataract Category System
Congenital cataracts (CC) are the leading cause of childhood visual disabilities and treatable childhood blindness worldwide1. CC patients have a wide range of presentations of lens opacities and are generally categorized into…
- Trial name
- NCT02793869
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Sun Yat-sen University
Fuchs Endothelial Corneal Dystrophy
SUCCESS Score Validation in Fuchs Dystrophy
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal…
- Trial name
- SUCCESS (NCT07265388)
- Testing
- Phacoemulsification Cataract Surgery
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Instituto Ramón y Cajal de Investigación Sanitaria
Crystalline Cataract, Lens; Anomaly
Age-related Changes of Crystalline Lens Tilt and Decentration: A Swept-source Optical Coherence Tomography Study
230 participants at Eye Hospital of Wenzhou Medical University during June, 2019 and August, 2019 were enrolled in this study. 230 right eyes and 88 left eyes were included for the measurement.
- Trial name
- NCT04487795
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Yune Zhao
Fuchs Endothelial Corneal Dystrophy
A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.
- Trial name
- NCT05826353
- Testing
- Ripasudil
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 110 people
- Sponsor
- Kowa Research Institute, Inc.
Cerebrotendinous Xanthomatosis
The Prevalence of CTX Disorder in Juvenile Cataract Cases in Turkey
Epidemiologic observational study. Study will include two phases: 1. Retrospective cross-sectional phase: At this stage of the study, retrospective screenings are carried out at study sites and all juvenile cataract cases are…
- Trial name
- GEN-EYE-I (NCT03584893)
- Testing
- Blood sampling for Cholestanol Analysis
- Where
- 36 sites in Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- TRPHARM
Congenital Cataract
Digital Imaging Versus Ophthalmoscopy
Cataract (cloudiness of the lens) is the major cause of avoidable child blindness in the world and affects 1 in 3000 UK infants.
- Trial name
- DIvO (NCT05282147)
- Testing
- Neocam
- Volunteers
- 140,000 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Congenital Cataract
Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy
Selecting the appropriate surgical approach for congenital cataracts presents challenging for ophthalmologists. This prospective, randomized controlled study aims to compare the prognosis of posterior continuous curvilinear…
- Trial name
- NCT05136209
- Testing
- PCCC procedure without A-vit, PCCC+A-Vit procedure
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Fuchs Endothelial Corneal Dystrophy, Cataract
The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy
The goal of this study is to learn if topical ROCK inhibitors protect endothelial corneal cells in patients with glaucoma and Fuchs endothelial corneal dystrophy after cataract surgery.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Cataract, Glaucoma
- Trial name
- NCT06969586
- Testing
- Netarsudil 0.02% Ophthalmic Solution, artificial tear substitute
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Pediatric Glaucoma
Combined Phacoaspiration and Angle Surgery Versus Phacoaspiration in Pediatric Cataract
The aim of this study is to report the effectiveness of phacoaspiration when combined with angle surgery in preventing postoperative glaucoma following pediatric cataract surgery
- Trial name
- NCT05401760
- Testing
- Group A :combined phacoaspiration and angle surgery, Group B : phacoaspiration only
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Congenital Cataract
The Impact of Interactive, Multifaceted Approach Education on Congenital Cataract
To evaluate the impact of a health education program on parental anxiety, the comprehension-memorization of the information and their satisfaction.
- Trial name
- NCT03564990
- Testing
- interactive, multifaceted approach, conventional approach
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Unilateral Cataract Extraction, Congenital Cataract
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
The purpose of this study is to evaluate the effect of OMS302 compared to phenylephrine when administered in irrigation solution during cataract extraction on intraoperative pupil diameter, acute postoperative pain, and safety in…
- Trial name
- ILR7 (NCT02132312)
- Testing
- OMS302, Phenylephrine HCl
- Where
- 11 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeros Corporation
Congenital Cataract
Infant Aphakia Treatment Study (IATS)
The primary purpose is to determine whether infants with a unilateral congenital cataract are more likely to develop better vision following cataract extraction surgery if they undergo primary implantation of an intraocular lens…
- Trial name
- IATS (NCT00212134)
- Testing
- Contact lens correction of aphakia, Intraocular lens implantation
- Where
- 13 sites in United States
- Volunteers
- 114 people
- Sponsor
- Stanford University
Fuchs' Corneal Dystrophy, Cataract
Combined Cataract Surgery and Planned Descemetorhexis
A pilot study designed to assess the feasibility of planned descemetorhexis for the treatment of Fuchs' corneal dystrophy.
- Trial name
- NCT02206594
- Testing
- Descemetorhexis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical College of Wisconsin
Lowe Syndrome
Genetic Analysis of Oculocerebrorenal Syndrome of Lowe
This study will investigate the genetic basis of oculocerebrorenal syndrome of Lowe (OCRL)-a rare X-linked disorder (carried by females and passed to males).
- Trial name
- NCT00359515
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Human Genome Research Institute (NHGRI)