Clinical trials: Confusional State
Diplopia, Binocular Vision Suppression
Understanding Visual Confusion Using Stereoscopic Displays
In this research study we want to test how people understand a visual scene when the same image is presented to both the eyes, but portions of these images are altered in terms of contrast, depth or in some cases motion.
- Conditions
- Diplopia, Binocular Vision Suppression, Binocular; Fusion, With Defective Stereopsis, Monocular Diplopia
- Trial name
- NCT04957745
- Testing
- Binocular visual confusion (unilateral opaque), Unilateral monocular visual confusion (unilateral see-through), Bilateral monocular visual confusion (bilateral see-through)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Delirium, Sleep Fragmentation
Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones
This study seeks to examine the effects of overnight noise reduction in critically ill patients who are receiving mechanical ventilation.
- Trial name
- NCT01343095
- Testing
- Foam Earplugs, Noise Canceling Headphones
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University
Acute Kidney Injury, Post-Operative Delirium
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that…
- Conditions
- Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure
- Trial name
- NCT00791648
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Vanderbilt University Medical Center
Strabismus
Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
This study evaluates the association between the depth of general anesthesia and the occurrence of emergence agitation (EA). The investigators hypothesized that optimal level of anesthetic depth could decrease the incidence of EA…
- Trial name
- NCT02521259
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Bundang Hospital
Agitation, Anesthesia
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Emergence delirium (ED) from general anesthesia posts risk and harm to pediatric population undergo general anesthesia. The purpose of the study is to compare the use of dexmedetomidine versus placebo in reducing the incidence…
- Conditions
- Agitation, Anesthesia, Pediatrics
- Trial name
- DexPeds (NCT00857727)
- Testing
- Dexmedetomidine, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Delirium, Agitation
Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium
The purpose of the research is to see if dexmedetomidine (a drug that has a calming effect - a sedative) is effective for the treatment of acute delirium
- Trial name
- NCT00351299
- Testing
- Dexmedetomidine, Standard of Care
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Delirium
The Effect of Guanfacine on Delirium in Critically Ill Patients
Delirium in patients in the intensive care unit (ICU) is a common problem associated with increased mortality and morbidity, including increased hospital and ICU length of stay, greater hospital cost, increased ventilator days…
- Trial name
- NCT04578886
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Delirium, Impaired Cognition
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
The long-term objective of the MIND-USA (Modifying the Impact of ICU-Induced Neurological Dysfunction-USA) Study is to define the role of antipsychotics in the management of delirium in vulnerable critically ill patients.
- Conditions
- Delirium, Impaired Cognition, Long Term Psychologic Disorders
- Trial name
- MIND-USA (NCT01211522)
- Testing
- Haloperidol, Ziprasidone
- Where
- 16 sites in United States
- Volunteers
- 566 people
- Sponsor
- Vanderbilt University Medical Center
Delirium
Prevention of Delirium After Bone Marrow Transplantation
The purpose of this study is to find out if using bright light sessions during bone marrow transplant can prevent people from developing confusion also known as delirium.
- Trial name
- NCT01700816
- Testing
- Bright light therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Delirium, Respiratory Depression
Acupuncture for Sedation in the Intensive Care Unit (ICU)
BACKGROUND Many patients in the trauma intensive care unit (TICU) require mechanical ventilation and sedation or anxiolysis. Mechanical ventilation means that a machine is helping a patient breathe if he can't breathe on his own.
- Conditions
- Delirium, Respiratory Depression, Overmedication
- Trial name
- NCT01362270
- Testing
- Verum Acupuncture
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Hip Fractures, Delirium
Post-Operative Delirium in Elderly Surgical Patients
This research is being done to see what effects sedative drugs during surgery have on peoples' thinking processes after they wake up.
- Trial name
- STRIDE (NCT00590707)
- Testing
- Deeper sedation, Moderate sedation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Postoperative Pain, Postoperative Delirium
Multimodal Versus Opioid aNalgesia in carDiAc Surgery
To compare standard "Fentanyl - Tramadol - Paracetamol - Oxycodone" regimen to a multimodal painmanagement "pregabalin- minimal fentanyl-ketamine-lidocain-dexmedetomidine- paracetamol" to determine which therapy provides the most…
- Trial name
- MONDAY (NCT04987372)
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Post Operative Delirium
Effect of Anesthesia on Post-operative Delirium in Elderly Patients Undergoing Hip Fracture Surgery
The purpose of this study is evaluate postoperative delirium after general anesthesia and regional anesthesia in elderly patients undergoing hip fracture surgery.
- Trial name
- RAGADelirium (NCT02213380)
- Testing
- method of anesthesia
- Where
- 13 sites in China
- Volunteers
- 950 people
- Sponsor
- Wenzhou Medical University
Delirium
Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
This is a pilot randomized controlled trial that will test whether a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical…
- Trial name
- NCT04007523
- Testing
- Family Support System, HELP Support System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Postoperative Delirium, Sleep
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
This study aims to determine whether, compared with placebo, the nighttime administration of a intravenous dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in extubated post-cardiac surgical…
- Conditions
- Postoperative Delirium, Sleep, Anesthesia
- Trial name
- MINDDS (NCT02856594)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Emergence Delirium
Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
The aim of this study is to investigate the effect of sugammadex vs. a conventional acetylcholinesterase inhibitor, neostigmine on emergence delirium (ED) during sevoflurane-rocuronium anesthesia in pediatric patients…
- Trial name
- NCT03229486
- Testing
- Sugammadex Injection [Bridion], Neostigmine+Glycopyrronium
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Pusan National University Yangsan Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
This research study will evaluate the effectiveness and estimate the feasibility of administering an investigational drug called 'CN-105' (the study drug), to prevent postoperative cognitive decline, delirium (serious confusion)…
- Trial name
- MARBLE (NCT03802396)
- Testing
- CN-105
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Miles Berger, MD PhD
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University