Clinical trials: Concussion Mild
Traumatic Brain Injury
TBI MR Study 3 Houston Methodist
This hypothesis-generating feasibility study to determine potential associations between a broad range of clinical neurological symptoms and Magnetic Resonance Image (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- NCT02218216
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- GE Healthcare
Mild Traumatic Brain Injury
Mobilizing Early Management of Mental Health Complications After Mild Traumatic Brain Injury
Mental health problems frequently complicate recovery from mild traumatic brain injury (mTBI) but are under-recognized and under-treated.
- Trial name
- M4 (NCT04704037)
- Testing
- Guideline implementation tool, Generic information about concussion management
- Where
- 9 sites in Canada
- Volunteers
- 537 people
- Sponsor
- University of British Columbia
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Balance and Mild Traumatic Brain Injury: The Effect of a Weighted Compression Vest
After a mild traumatic brain injury (mTBI) people often report balance problems. At Parkwood hospital we have noticed that balance is improved when patients with mTBI wear a weighted compression vest.
- Trial name
- NCT02084329
- Testing
- Weighted Compression Vest
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Concussion, Mild
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the sub-acute period after concussion, and to document the…
- Trial name
- Breathe (NCT06559865)
- Testing
- Breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Persistent Post Traumatic Headache, Mild Traumatic Brain Injury
Remotely Supervised tDCS for Persistent Post-traumatic Headache
This pilot study is designed to provide preliminary data for a large scale, randomized clinical trial to evaluate the efficacy of remotely administrated at home transcranial Direct Current Stimulation (tDCS) with real-time…
- Trial name
- tDCS for PTH (NCT04012853)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Brain Concussion
Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion
Previous research and position statements have outlined the necessity of balance and gait testing in the post-concussion evaluation of athletes.
- Trial name
- NCT02317107
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Mild Traumatic Brain Injury, Post-Concussion Syndrome
Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury
A substantial number of children and adolescents sustain a mild traumatic brain injury (mTBI) each year. Although research supports that the vast majority of youth will recover quickly and return to normal functioning, some…
- Conditions
- Mild Traumatic Brain Injury, Post-Concussion Syndrome, Insomnia
- Trial name
- NCT03688984
- Testing
- Cognitive Behavioural Therapy for Insomnia
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Persisting Symptoms After Concussion
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persisting symptoms…
- Trial name
- PatACT (NCT06615908)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Post-Traumatic Stress Disorders, Traumatic Brain Injury
Rural Veterans With Post-traumatic Stress Disorder (PTSD) And Comorbid Mild Traumatic Brain Injury (TBI): A Feasibility Study
This study is being conducted to understand whether training in tasks that require perceiving and thinking about things, or cognition, can improve memory in veterans who have been exposed to a blast explosion and have TBI and…
- Trial name
- NCT01278316
- Testing
- Control, Cognitive Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Concussion, Mild
Australian University of California San Francisco (UCSF) Concussion in Athletes (AUSSIE-2)
Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes.
- Trial name
- AUSSIE-2 (NCT05771051)
- Testing
- Headpulse measurements
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Traumatic Brain Injury, Brain Concussion
Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
The purpose of this single center, longitudinal, pilot study is to provide evidence for the use of an eye tracking system as an objective tool to identify mild traumatic brain injury (mTBI) related oculomotor dysfunction (OMD)…
- Conditions
- Mild Traumatic Brain Injury, Brain Concussion, Convergence Insufficiency, Accommodative Insufficiency
- Trial name
- NCT03319966
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Hennepin Healthcare Research Institute
Brain Injuries, Concussion, Mild
Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
This study is designed to collect data which will be used to associate changes in EEG, neurocognitive performance, eNPC and clinical symptoms in concussion subtypes.
- Conditions
- Brain Injuries, Concussion, Mild, Concussion, Brain, Near Point Convergence
- Trial name
- BSC-CI-NPC (NCT04074486)
- Testing
- BrainScope Ahead 300iP-O, SCAT5, Near Point Convergence
- Where
- 6 sites in United States
- Volunteers
- 1,318 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Post-Concussion Syndrome, Traumatic Brain Injury
Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of…
- Trial name
- NCT02089594
- Testing
- Hyperbaric Oxygen, No Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Concussion, Brain, Mild Traumatic Brain Injury
Risk Stratification in Children With Concussion
This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children…
- Trial name
- RSiCC (NCT05825027)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Fatigue, Traumatic Brain Injury
Service Member Fatigue and Lack of Motivation Following Concussion
Background: Many service members have reported feeling tired, a loss of motivation, mood changes, and problems working with others after they have a concussion during deployment.
- Trial name
- NCT01496586
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Concussion, Brain, Pediatric Disorder
RECOVER Clinical Pathway for Pediatric Concussion
The project encompasses the development and implementation of an acute care, pediatric concussion clinical pathway at 5 pediatric emergency departments in the province of Alberta (Canada).
- Conditions
- Concussion, Brain, Pediatric Disorder, Mild Traumatic Brain Injury
- Trial name
- RECOVER (NCT05095012)
- Testing
- Pediatric Acute Care Concussion Clinical Pathway
- Where
- Canada
- Volunteers
- 2,878 people
- Sponsor
- University of Calgary