Clinical trials: Concussion
Brain Concussion
Exercise Reset for Concussion in a Military Environment
Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM.
- Trial name
- NCT05498038
- Testing
- Aerobic Exercise
- Where
- 2 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury
Kids Injury Detection Study Using the i-STAT
KIDS-STAT is a prospective study evaluating whether a rapid blood test measuring the brain injury biomarkers GFAP and UCH-L1 using the i-STAT Alinity system can help identify children with mild traumatic brain injury who do not…
- Conditions
- Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury, Head Trauma
- Trial name
- KIDS-STAT (NCT07835919)
- Testing
- i-STAT TBI Cartridge with the i-STAT Alinity System
- Volunteers
- 700 people
- Sponsor
- Children's Healthcare of Atlanta
Concussion, Brain, Treatment
Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects…
- Conditions
- Concussion, Brain, Treatment, Aerobic Exercise, Inflammation
- Trial name
- MEDIC (NCT05434130)
- Testing
- High Dose Exercise
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Colorado, Denver
Mild Traumatic Brain Injury, Suicidal Ideation
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicidal Ideation, Impulsivity
- Trial name
- NCT05647044
- Testing
- intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Focus: Healthy Adults Without Brain Injury
Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL)
The purpose of the research study is to collect information about brain function and structure among active duty military personnel or civilians who are healthy.
- Trial name
- NORMAL (NCT01925963)
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Lindell Weaver
Mild Traumatic Brain Injury (mTBI), Traumatic Brain Injury
Examining the Efficacy of the Man Therapy Platform in Reducing Problematic Anger Among Military Service Members With and Without a TBI History
The goal of this randomized controlled trial is to determine if an interactive digital solution, Man Therapy, reduces indices of problematic anger in male military service members who screen positive for problematic anger.
- Conditions
- Mild Traumatic Brain Injury (mTBI), Traumatic Brain Injury, Anger
- Trial name
- NCT07604701
- Testing
- Man Therapy
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Colorado, Denver
Mild Traumatic Brain Injury
Evaluating Huddles as a Novel Approach to Improving Concussion Safety
Investigators will conduct a randomized controlled trial assessing the effectiveness and implementations of Pre-Game Safety Huddles (Huddles) in youth soccer.
- Trial name
- NCT06864611
- Testing
- Pre-Game Safety Huddles
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Concussion, Intermediate
Unblinded Data Collection Study of Concussion Using BrainPulse
This is a prospective, non-blinded, matched control study of young athletes (ages 10-28 years old) in collegiate sports. The cohorts are defined in accordance to the athlete's exposure of injury.
- Trial name
- NCT02992795
- Testing
- BrainPulse
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of all TBI, and although its prognosis is…
- Trial name
- BIOTRABIS (NCT04641767)
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Virgen Macarena
Concussion, Mild
Sex and Age Ultrasound Response to Differential Jugular Vein Pressure
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03017937
- Testing
- Q-collar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild
Reverse King-Devick Test and History of Multiple Concussions
The purpose of this study is to examine the effects of concussion history and reading direction on baseline King- Devick Test (KDT) performance, a common component of sideline concussion assessments.
- Trial name
- NCT04560400
- Testing
- Conventional King-Devick test, Reverse King-Devick test
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sports-related Concussion
The Impact of Riboflavin on Sports-related Concussion
The purpose of this study is to investigate the effectiveness of riboflavin to decrease the duration of time for a student-athlete to return to participation in sports after a sports related concussion.
- Trial name
- NCT02772237
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Post Concussive Syndrome, Concussion
Pulsed Electromagnetic Field (PEMF) Therapy for Post-Concussive Syndrome
The objectives are to evaluate impact of Pulsed electromagnetic field (PEMF) therapy on patients with Post-Concussive Syndrome with Rivermead Post Concussion Symptom Questionnaire (RPQ) as a primary outcome, followed by fatigue…
- Trial name
- PEMF (NCT02643836)
- Testing
- PEMF
- Sponsor
- Spaulding Rehabilitation Hospital
Post Concussion Syndrome
mHealth Technology in the Treatment of Post-concussion Symptoms
Patients with concussion symptoms are asked by their doctors to stretch, exercise, and practice mindfulness daily. Patients can have a hard time sticking to these activities, which can cause patients to feel symptoms for longer…
- Trial name
- PERSIST (NCT05848193)
- Testing
- MyHeadHealth online application, Standard of Care
- Volunteers
- 88 people
- Sponsor
- McMaster University
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Concussion Post Syndrome, Concussion
Effect of Vestibular Rehabilitation on Gait, Balance, and Coordination in Post Concussion Combat Athletes
This randomized controlled trial aims to evaluate the effectiveness of vestibular rehabilitation in improving gait and balance among post-concussion combat athletes aged 18-25 years.
- Trial name
- NCT07717528
- Testing
- Vestibular Rehabilitation Program, Conventional Post-Concussion Rehabilitation
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Depressive Symptoms, Mild Traumatic Brain Injury
Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel
The Center for Neuroscience and Regenerative Medicine (CNRM) Clinical Trials Unit has developed the first cognitive-behavioral therapy (CBT) digital therapeutic (DTx) mobile application to counteract depressive symptoms in…
- Trial name
- NCT05147506
- Testing
- CNRM DTx, Psychoeducation Comparison
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Mild Traumatic Brain Injury, Concussion
Effect of Early Rest on Recovery From Pediatric Concussion
The purpose of this study is to find out if strict rest for 5 days helps children get better after concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
- Trial name
- NCT01101724
- Testing
- Mandated Rest, Intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical College of Wisconsin
Brain Injuries, Brain Concussion
Measuring Head Impacts in Sports
Head impacts in sports can lead to brain injury even when the participant is wearing a helmet. The forces that contribute to brain injury from sports-related head impacts are not well understood.
- Trial name
- NCT00060827
- Testing
- Head Impact Recording Technology (HIRT)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Craniocerebral Trauma, Head Injury, Minor
Exercise in Patients With Post-Concussion Symptoms
Physical activity and exercise have traditionally not been much of a focus in treatment of postconcussion symptoms and posttraumatic headache.
- Conditions
- Craniocerebral Trauma, Head Injury, Minor, Postconcussion Syndrome, Posttraumatic Headache
- Trial name
- NCT04001192
- Testing
- aerobic exercise program
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital