Clinical trials: Concussion, Mild Traumatic Brain Injury
Mild Traumatic Brain Injury
Pro-2-Cool Device Clinical Study
This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling when applied up to 8 days after mild traumatic brain injury (mTBI) among adolescents participating in sporting activities.
- Trial name
- NCT03511339
- Testing
- TecTraum device
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- TecTraum Inc.
Mild Traumatic Brain Injury
Change in Connectivity After mTBI Depending on Cognitive Reserve
The purpose of this study is to investigate the role of cognitive reserve in change in connectivity in the brain (measured with functional magnetic resonance imaging, fMRI) and how this is related to symptoms and symptom…
- Trial name
- NCT05593172
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Danderyd Hospital
Mild Traumatic Brain Injury, Concussion (Diagnosis)
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
Objectives: Approximately one-third of patients with concussion experience persistent symptoms that, in addition to causing serious discomfort, may lead to unemployment and other socioeconomic challenges.
- Trial name
- NCT06644131
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Southern Denmark
Brain Concussion, Brain Injuries
Indirect Intracranial Pressure Measurement in Patients With Suspected or Documented Concussion
The HS-1000 is an innovative non-invasive monitoring device that employs advanced acoustic signal analysis to calculate ICP on a continuous basis.
- Trial name
- NCT02699359
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Children, Only, Traumatic Brain Injury
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
EEG signals have been collected and studied since the early 1990's as a way of assessing brain function at a gross level. As early as the 1930's a derivative of the raw EEG signal - event-related potentials (ERPs) - have been…
- Conditions
- Children, Only, Traumatic Brain Injury, Concussion, Mild, Pediatric ALL
- Trial name
- NCT03889483
- Testing
- NeuroCatch™ Platform
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Esser
Brain Concussion, Cerebral Concussion
Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED)…
- Conditions
- Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild
- Trial name
- DETECT (NCT02776462)
- Testing
- EyeBox CNS
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Oculogica, Inc.
Brain Concussion
Telephone Follow-Up on Outcome After Mild Traumatic Brain Injury
The purpose of this study is to see whether providing education and counseling after a mild traumatic brain injury will help in preventing symptoms from becoming chronic over the first six months after injury.
- Trial name
- TBI (NCT00483444)
- Testing
- Scheduled telephone follow-up
- Where
- United States
- Volunteers
- 366 people
- Sponsor
- University of Washington
Brain Injuries, Traumatic, Concussion, Mild
Objective Brain Function Assessment of mTBI/Concussion
This study (Part 3) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- CAS13-25 (NCT03963804)
- Testing
- BrainScope Ahead 300iP
- Where
- 4 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Post-Traumatic Stress Disorders, Traumatic Brain Injury
Rural Veterans With Post-traumatic Stress Disorder (PTSD) And Comorbid Mild Traumatic Brain Injury (TBI): A Feasibility Study
This study is being conducted to understand whether training in tasks that require perceiving and thinking about things, or cognition, can improve memory in veterans who have been exposed to a blast explosion and have TBI and…
- Trial name
- NCT01278316
- Testing
- Control, Cognitive Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Post Traumatic Stress Disorder
Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury
A pilot study to evaluate feasibility for a full-scale merit application. Specifically, for veterans considering prolonged exposure (PE) therapy, following the model established by Foa et al, we need to establish safety, and…
- Trial name
- NCT04280965
- Testing
- Quetiapine Fumarate, Standard of care meducations
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain Concussion, Vestibular Disorder
Portable Mixed Reality-based Platform for Assessment of Progress in Multisensory Rehabilitation Strategies Post-TBI
The goal of this comparative pilot study is to provide evidence that Praxis, a portable testbed with low-cost wearable sensors and a mixed reality environment, can deliver effective multisensory rehabilitation exercises with…
- Conditions
- Brain Concussion, Vestibular Disorder, Cognition Disorder, Mild Traumatic Brain Injury
- Trial name
- Praxis (NCT06314464)
- Testing
- Praxis, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- BlueHalo
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Transcranial Magnetic Stimulation, Magnetic Resonance Imaging
Brain Stimulation for Concussion
The goal of this clinical trial is to test a new type of magnetic brain stimulation in patients with persistent post-concussive symptoms.
- Conditions
- Transcranial Magnetic Stimulation, Magnetic Resonance Imaging, Neuropsychological Tests, Traumatic Brain Injury
- Trial name
- NCT05889117
- Testing
- Intermittent theta-burst treatment (iTBS) using MagPro Transcranial Magnetic Stimulator (manufacturer: Magventure)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Mind Research Network
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Brain Concussion
The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury
The study is a "proof-of-principle" project to examine the safety and feasibility of implementing a 1-week aerobic exercise program in the post-acute phase after mild traumatic brain injury (mTBI).
- Trial name
- NCT02276079
- Testing
- Aerobic Exercise, Non-Aerobic Exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mild Traumatic Brain Injury, Concussion, Mild
Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) accounts for 70-90% of all diagnosed traumatic brain injuries (TBI) affecting approximately 50-300 per 100.000 individuals annually.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Academic Achievement, Specific Academic or Work Inhibition
- Trial name
- NCT03678077
- Testing
- Mild traumatic brain injury
- Where
- Denmark
- Volunteers
- 45,777 people
- Sponsor
- University of Copenhagen
Mild Traumatic Brain Injury
Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Pilot Trial)
The purpose of this study is to determine the feasibility of combining PoNS therapy with standard vestibular and balance therapy with the proposed double-blind design; evaluate preliminary indications of efficacy.
- Trial name
- NCT02109198
- Testing
- Active CN-NINM PoNS
- Where
- 2 sites in United States
- Sponsor
- U.S. Army Medical Research and Development Command
Concussion, Mild Traumatic Brain Injury
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
In recent years, media attention has focused on the long-term sequelae of repeated concussive episodes in professional athletes.
- Trial name
- NCT01903525
- Testing
- Docosahexaenoic acid (DHA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Concussion, Mild
fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population
This study aims to investigate the efficacy and tolerability of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in the treatment of depressive symptoms in service members with a history of concussive traumatic…
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Depressive Symptoms
- Trial name
- NCT03523507
- Testing
- Active: rTMS
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cerebral Concussion
Concussion in French Amateur Rugby : Survey About the Management and Knowledge of Players
Rugby is a popular contact sport in France the majority of whom are amateur players. Concussion is one of the main risks given its potential severity and frequency (between 2.78 and 10 per 1,000 player hours).
- Trial name
- RUGBY-COM (NCT04760834)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux