Clinical trials: Computer Simulation
Motion Sickness, Space, Motion Simulation
Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance
The primary specific aim of this Field Test aim is to evaluate the feasibility and efficacy of administering the intranasal scopolamine gel in operational field settings using both astronaut and ground-control subjects that are…
- Conditions
- Motion Sickness, Space, Motion Simulation, Parabolic Flight
- Trial name
- NCT05852730
- Testing
- DPI-386 Nasal Gel, Other (e.g., promethazine, meclizine)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Repurposed Therapeutics, Inc.
Pelvic Organ Prolapse
A Surgical Simulation Study to Evaluate the Safety of a Device Mechanism as Treatment for Vaginal Apical Prolapse
The purpose of this pilot study is to perform a procedure to evaluate the safety of the placement of a new device (known as the VFIX device).
- Trial name
- NCT00965952
- Where
- 4 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Ethicon, Inc.
Hypercholesterolemia
Study of HSK31679 in Subjects With Hypercholesterolemia With Nonalcoholic Fatty Liver Disease（NAFLD）
The purpose of this study is to assess the efficacy and safety of HSK31679 tablets compared with placebo in reducing low-density lipoprotein cholesterol (LDL-C) and MRI-PDFF after 12 weeks of treatment in patients with…
- Trial name
- NCT05795517
- Testing
- HSK31679 low dose, HSK31679 medium dose, HSK31679 high dose
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Infra Renal Aortic Aneurysm
Patient-Specific Simulation Used for EVAR Procedure Rehearsal - Evaluation of Clinical Performance With and Without Prior Rehearsal
The purpose of this study is to evaluate the procedural and clinical benefits of patient specific pre-procedure rehearsal for operators with various experience levels as a tool for optimizing Endovascular Aneurysm Repair (EVAR)…
- Trial name
- PRS (NCT02151942)
- Where
- 7 sites in United States, France and 1 more
- Volunteers
- 150 people
- Sponsor
- Simbionix US Corporation
PHYSIOLOGICAL PHENOMENA, Homeostasis
Truway Whole-Body Digital Twin and Physiologic Resilience Study (TRU-OMNIBODY)
TRU-OMNIBODY is a prospective observational study designed to develop and independently validate a research-only whole-body digital twin.
- Conditions
- PHYSIOLOGICAL PHENOMENA, Homeostasis, Physical Functional Performance, Cardiorespiratory Fitness
- Trial name
- TRU-OMNIBODY (NCT07805044)
- Testing
- Standardized Physiologic Resilience Challenge, Multimodal Whole-Body Physiologic Monitoring, Research-Only Whole-Body Digital Twin Analysis
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Asthma, COPD
Breathing Parameter Measurements for Lung Deposition Simulation
This study aims to simulate the deposition of aerosol drugs within the airways of asthma and COPD patients based on realistic breathing patterns measured at different pulmonology centers.
- Trial name
- CHOICE (NCT05445349)
- Testing
- Emptied dry powder inhalers (DPI) used in routine asthma and COPD therapy
- Where
- 3 sites in Hungary
- Volunteers
- 163 people
- Sponsor
- Medisol Development Kft.
Diabetic Peripheral Neuropathic Pain (DPNP)
YJ001 Spray for Diabetic Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if YJ001 Spray works to treat diabetic patients with Diabetic Peripheral Neuropathic Pain..It will also learn about the safety of drug YJ001 Spray.This trial is divided into two parts.
- Trial name
- NCT07859111
- Testing
- YJ001 spray simulant, YJ001 spray, Crisugabalin Besilate Capsules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhejiang Hanmai Pharmaceutical Technology Co., Ltd.
COVID, Drug Effect
Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy
This retrospective study aims to perform a medication risk stratification using drug claims data and to simulate the impact of the addition of various repurposed drugs on the Medication Risk Score (MRS) in elderly people enrolled…
- Conditions
- COVID, Drug Effect, Drug Interaction, Adverse Drug Event
- Trial name
- NCT04339634
- Testing
- Simulation of Repurposed Drugs for COVID-19
- Where
- United States
- Volunteers
- 12,873 people
- Sponsor
- Tabula Rasa HealthCare
Manual Ventilation
Prolonged Manual Ventilation Simulation
A pilot study on simulated lung scenarios using the standard manual resuscitator bag, flow limiting resuscitator bag, and an FDA approved flow rate limiting device paired with a standard manual resuscitator.
- Trial name
- NCT06805838
- Testing
- Sotair
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- SafeBVM
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
AIDS
A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment
The primary objective of this trial was to evaluate the safety and preliminary evaluation of Azvudine tablets (FNC) in combination with reverse transcriptase inhibitors therapy in treatment-naive patients with HIV infection.; the…
- Trial name
- FNC (NCT04109183)
- Testing
- The subjects were randomized to the treatment group of 3TC or different doses of FNC. The background drugs were EFV and TDF.
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Henan Genuine Biotech Co., Ltd.
Hepatocellular Carcinoma (HCC)
Computer Guided Microwave Liver Ablation
The goal of this clinical trial is to learn if the intraoperative use of a computer guidance software can improve the success of liver tumor ablation in adults.
- Trial name
- MWA Sim (NCT07226869)
- Testing
- Computer-Assisted Microwave Liver Ablation
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- NE Scientific INC
Effect of Game in Increasing Environmental Health Literacy
Evaluation of Prototype for Simulation for Environmental Exposure Education (SE3)
The goal of this clinical trial is to test a prototype of a new educational game about environmental health literacy with middle school age youth.
- Trial name
- SE3 (NCT05875467)
- Testing
- SE3 Game
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- dfusion Inc
IVF, Controlled Ovarian Simulation
Menopur And Rekovelle Combination Study Version 2.0
The goal of this clinical trial is to evaluate the safety and effectiveness of a personalized ovarian stimulation regimen in women aged 18 to 40 undergoing in vitro fertilization (IVF).
- Conditions
- IVF, Controlled Ovarian Simulation, Fertility Disorders
- Trial name
- MARCS 2 (NCT06997900)
- Testing
- Combination therapy : Follitropin delta and HP-hMG
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Clinique Ovo
Critical Illness, Mechanical Ventilation
Proof of Concept Trial to Confirm That the Recovery of Patients Treated in the Intensive Care Unit Requiring Mechanical Ventilation is Beneficially Affected by the Environmental Simulation of Daytime and Night Time Alternation as Well as by the Nutrition Protocol Corresponding to the Daily Rhythm
The purpose of this study is to determine whether the environmental simulation of daytime and night time alternation as well as by the nutrition protocol corresponding to the daily rhythm are beneficially affect the recovery of…
- Trial name
- NCT02828722
- Testing
- Controlled light and noise, Controlled nutrition
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Achros Health Technologies Corporation
Atherosclerotic Cardiovascular Disease
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Study CKJX839B1FR01 in an In silico trial to predict the efficacy of Inclisiran therapy on major adverse cardiovascular events (MACE) and cardiovascular (CV) death in virtual patients with atherosclerotic cardiovascular disease…
- Trial name
- SIRIUS (NCT05974345)
- Testing
- Inclisiran sodium, Ezetimibe, Evolocumab
- Where
- France
- Volunteers
- 204,691 people
- Sponsor
- Novartis Pharmaceuticals
Major Depressive Disorder
Study of Desvenlafaxine in Treating Major Depressive Disorder.
The primary purpose of this study is to evaluate if the effectiveness of desvenlafaxine succinate sustained-release tablet (50 mg/day) used for 8 weeks is not inferior to duloxetine hydrochloride enteric-coated capsule (60…
- Trial name
- NCT04364997
- Testing
- Duloxetine Hydrochloride Enteric-coated Capsule
- Where
- China
- Volunteers
- 420 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Controlled Ovarian Simulation
Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Pan-Asian Women
To demonstrate non-inferiority of FE 999049 compared with GONAL-F with respect to ongoing pregnancy rate in women undergoing controlled ovarian stimulation.
- Trial name
- NCT03296527
- Testing
- Follitropin alfa, Follitropin delta
- Where
- 26 sites in China, South Korea and 2 more
- Volunteers
- 1,011 people
- Sponsor
- Ferring Pharmaceuticals
Unruptured Intracranial Aneurysm
Assessment of the Clinical and Economic Impact of Sim&Size, a Simulation Software for Implantable Devices Used in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study.
In recent years, endovascular treatment of intracranial aneurysms has seen remarkable growth, now surpassing traditional surgical approaches in terms of frequency of use.
- Trial name
- ESSNAI (NCT07433075)
- Testing
- 3D simulation of placement of neurovascular implantable medical device, Manual planning of endovascular procedure
- Where
- 6 sites in France
- Volunteers
- 576 people
- Sponsor
- Sim&Cure
Infertile Female Subjects Undergoing Controlled Ovarian Hyperstimulation to Suppress Premature LH Surge and Prevent Early Ovulation
To Compare the Efficacy and Safety of Oral SHR 7280 Tablets With Ganirelix Acetate Injection in Infertile Female Subjects
This study is a multi-center, randomized, double-blind, positive drug-controlled, non-inferiority Phase III clinical trial. The study will enroll approximately 316 infertile female subjects undergoing controlled ovarian…
- Trial name
- NCT05994378
- Testing
- SHR7280；Ganirelix Acetate Injection simulant, SHR7280 simulant； Ganirelix Acetate Injection
- Where
- China
- Volunteers
- 317 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.