Clinical trials: Complication of Transplanted Liver
Liver Transplant; Complications, Stress
Effects of Comedy Therapy on Anxiety and Vital Signs in Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pre-transplant anxiety levels and vital signs in liver transplant recipients.
- Conditions
- Liver Transplant; Complications, Stress, Care Acceptor, Health
- Trial name
- NCT06919588
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Liver Diseases, Alcoholic, Alcohol-Related Disorders
Cohort/Ethics Study of Patients With Severe Alcoholic Hepatitis Undergoing Early Liver Transplantation
The purpose of this study is to develop a clinical understanding of early liver transplantation (ELT) for patients with severe alcoholic hepatitis (SAH) and identify the public's opinion regarding this practice.
- Conditions
- Liver Diseases, Alcoholic, Alcohol-Related Disorders, Transplant; Failure, Liver, Transplant; Complication, Rejection
- Trial name
- NCT04234139
- Testing
- liver transplant
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Hepatic Artery Thrombosis, Liver Transplant; Complications
Ticagrelor in Post-transplant Patients With Pediatric Hepatic Artery Thrombosis (HAT)
Hepatic artery thrombosis (HAT) represents a major cause of graft loss and mortality after Pediatric liver transplantation. Ticagrelor (a new reversible inhibitor of P2Y12 receptor with faster onset of action and greater platelet…
- Conditions
- Hepatic Artery Thrombosis, Liver Transplant; Complications, Pediatric Disease
- Trial name
- Tip-HAT (NCT04946929)
- Testing
- Ticagrelor Oral Tablet [Brilinta], Low molecular weight heparin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- RenJi Hospital
Liver Transplant Rejection, Kidney Transplant; Complications
VOCs in Kidney and Liver Transplants
Kidney and liver trasplants represent very challenging lifesaving and effective surgical procedures for patients with end-stage kidney and/or liver disease.
- Trial name
- NCT04514666
- Testing
- Breath analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Liver Transplant
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.
- Trial name
- NCT00698399
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Liver Transplant; Complications, Infections
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
In our study, some inflammatory Interleukin-2 , Interleukin-6, Interferon-γ, Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid…
- Conditions
- Liver Transplant; Complications, Infections, Gene Amplification, Immune Response
- Trial name
- NCT05852964
- Testing
- Molecular Immunology , gene expressions
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
Unspecified Complication of Liver Transplant
Effectiveness of N-acetylcysteine on Preservation Solution During Liver Transplantation
Evaluate the effectiveness of the administration produced antioxidant N-acetylcysteine (NAC), decreasing the incidence of primary graft dysfunction and primary failure.
- Trial name
- NCT01866644
- Testing
- N-acetylcysteine, Saline
- Where
- Spain
- Volunteers
- 214 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Iron Overload
Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT
Hematopoietic Stem Cell Transplantation (HSCT) is currently a standard procedure for a wide range of blood-oncological diseases and genetic disorders.
- Trial name
- NCT04423237
- Testing
- Deferasirox
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- University of Pisa
Liver Transplant
Stented Biliary Anastomosis in Living Donor Liver Transplantation
Determination of biliary complications in stented group compared to duct to duct anastomosis without stent
- Trial name
- NCT03636321
- Testing
- living donor liver transplantation with internal biliary stent
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alaa Mstafa Hassan Sewefy
Liver Transplant; Complications, Quality of Life
Starzl Network Patient Reported Outcomes
This study uses a smartphone application/web interface (RealTime Clinic; RTC) to collect patient and parent reports of a pediatric liver transplant recipient's quality of life (QOL), and examines the extent to which QOL…
- Conditions
- Liver Transplant; Complications, Quality of Life, Child Behavior, Adolescent Behavior
- Trial name
- SPaRO (NCT05241847)
- Testing
- PeLTQL delivery via electronic means
- Where
- 7 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
5-day Defibrotide Treatment for Hepatic SOS/VOD
Sinusoidal Obstruction Syndrome (SOS), also referred to as hepatic veno-occlusive disease (VOD), is rare but serious complication of allogeneic stem cell transplantation (allo-SCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Bone Marrow Transplant Complications
- Trial name
- NCT04313036
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Loyola University
Acute Kidney Injury
Cell Cycle Arrest Proteins for Early Diagnosis of Acute Kidney Injury After Solid Organ Transplant
Renal failure is a common complication of lung transplant (LUTX) and orthotopic liver transplantation (OLTX). Early diagnosis of acute kidney injury (AKI) in this cohort is of utmost importance, since AKI after solid organ…
- Trial name
- LUTX/OLTX_AKI (NCT05907434)
- Testing
- Nephrocheck (AKI score)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Policlinico Hospital
End Stage Liver Disease, Impaired Renal Function
CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment
Background: Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors.
- Trial name
- PATRON07 (NCT00604357)
- Testing
- anti-CD 25 mAb, Sirolimus, MMF
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Regensburg
Complication, Death
The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation
Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients…
- Trial name
- NCT01711957
- Testing
- Liver transplantation
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Zurich
Infection
Postoperative Supplemental Oxygen in Liver Transplantation
The aim of this prospective randomized controlled trial is to evaluate the impact of high concentration supplemental postoperative oxygen therapy on short-term and long-term results of liver transplantation, particularly with…
- Trial name
- PSOLT (NCT02857855)
- Testing
- 80% fraction of inspired oxygen for 6 postoperative hours, 28% fraction of inspired oxygen for 6 postoperative hours
- Where
- Poland
- Volunteers
- 193 people
- Sponsor
- Medical University of Warsaw
Blood Loss, Surgical
QStat in Liver Transplant
This study will assess the clinical performance of the Quantra System with the QStat Cartridge in the liver transplant population.
- Trial name
- NCT04114253
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Liver Transplantation
Reducing Pain With Methadone and Ketamine in Liver Transplant
The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery.
- Trial name
- RELIEF-LT (NCT06868589)
- Testing
- Methadone, ketamine, Hydromorphone
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Lahey Clinic
Transfusion Related Complication
Effects of Packed Red Blood Cell Storage Duration on Pediatric Living Donor Liver Transplantation
The patients assigned to either short-storage leukoreduced RBCs group (stored for ≤ 14 days) or longer-term storage leukoreduced RBCs group(stored for ≥21 days).When the hemoglobin concentration fell below 7.0 g per deciliter…
- Trial name
- NCT04413721
- Testing
- RBC transfustion
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital