Clinical trials: Complication
Peri-Implant Health, Implant Complication
Influence of Zirconia Abutments on Peri-Implant Tissues in Single-Tooth Restorations
Objectives: To compare the influence of pre-fabricated titanium abutments and customized milled zirconia abutments on implant biocompatibility and the peri-implant region, as well as on radiographic bone loss and oral…
- Conditions
- Peri-Implant Health, Implant Complication, Prosthesis and Implants
- Trial name
- NCT07456163
- Testing
- Pre-fabricated standardized titanium abutments, Customized anatomical zirconia abutments
- Where
- Brazil
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Driving Pressure, Neuromuscular Blockade Monitoring
Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries
This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients…
- Conditions
- Driving Pressure, Neuromuscular Blockade Monitoring, Postoperative Respiratory Complications
- Trial name
- NCT07464288
- Testing
- Rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Breast Implant; Complications, Quality of Life
An Analysis of Adverse Events and Satisfaction Outcomes of Women Who Underwent Primary and Secondary Breast Augmentation Using Silimed® Breast Implants
The study investigates the safety and performance of Silimed® silicone gel breast implants with a textured surface and Silimed® silicone gel breast implants with polyurethane coated surface.
- Conditions
- Breast Implant; Complications, Quality of Life, Satisfaction
- Trial name
- STEPS A (NCT03356132)
- Testing
- Silimed® Textured Silicone Gel-Filled Breast Implant, Silimed® Polyurethane Foam Covered Silicone Gel-Filled Breast Implant
- Where
- Brazil
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- Silimed Industria de Implantes Ltda
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Postoperative Complications, Delayed Emergence From Anesthesia
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms.
- Conditions
- Postoperative Complications, Delayed Emergence From Anesthesia, Cognitive Dysfunction
- Trial name
- NCT04529304
- Testing
- Bilateral Bispectral Index and EEG
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Respiratory Function Loss, Respiratory Complication
Shear-wave Elastography Compared to Respiratory Function Testing
The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts…
- Trial name
- NCT04959526
- Testing
- Shear-wave elastography
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Implant; Complications, Quality of Life
An Analysis of Adverse Events and Satisfaction Outcomes of Women Who Underwent Primary and Secondary Breast Augmentation Using Silimed® Breast Implants With Smooth Surface
The study investigates the safety and performance of Silimed® brand smooth surface breast implants in women born with indication for primary and secondary (revision) augmentation to be followed up for 10 years.
- Conditions
- Breast Implant; Complications, Quality of Life, Satisfaction, Safety and Performance
- Trial name
- STEPS S (NCT05345821)
- Where
- Brazil
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Silimed Industria de Implantes Ltda
Rib Fractures, Oxygenation
Deep Breathing Exercises and Incentive Spirometry After Rib Fracture
Chest trauma patients constitute approximately 10-15% of all traffic accidents. Many complications may occur after chest trauma, including rib fracture, pneumothorax, hemothorax, lung contusion, flail chest, atelectasis…
- Trial name
- NCT06853002
- Testing
- Breathing exercise with spirometry, Breathing exercise with deep breathing method
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Samsun University
Joint (Knee or Hip Replacement), Infection as Complication of Medical Care
Swiss Revision Cohort
This study follows patients with infections after a joint replacement over time. During follow-up, treatment outcomes are carefully measured to determine whether the infection can be cured.
- Trial name
- REVCO (NCT07473089)
- Testing
- Revision for periprosthetic joint infections of the hip, knee, shoulder, elbow or ankle
- Where
- 5 sites in Switzerland
- Volunteers
- 329 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glioblastoma, Radiotherapy; Complications
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma
This study is to determine if an oral drug called Ramipril can lower the chance of memory loss in patients with glioblastoma getting chemoradiation.
- Conditions
- Glioblastoma, Radiotherapy; Complications, Cognitive Decline, Chemoradiation
- Trial name
- NCT03475186
- Testing
- Ramipril
- Where
- 423 sites in United States, Guam
- Volunteers
- 75 people
- Sponsor
- Wake Forest University Health Sciences
Nausea and Vomiting, Postoperative, Cesarean Section Complications
Dexamethasone vs Ondansetron After Cesarean Delivery
The goal of this clinical trial is to compare medications in women having a cesarean delivery. The main question it aims to answer are: Which medication is better to use as a first-line prevention agent for nausea and vomiting…
- Trial name
- NCT05692245
- Testing
- Ondansetron, Dexamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetes
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye
The intervention in this trial is intraocular islet transplantation. A single dose of 1000 - 3000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the eye through a self-sealing…
- Trial name
- NCT02846571
- Testing
- Human Pancreatic Islet Transplantation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Midhat H. Abdulreda
Pain, Procedural, Procedural Anxiety
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
The purpose of this study is to assess the use of virtual reality (VR) as an adjunct or alternative to pharmacologic sedation in pediatric patients undergoing renal biopsy.
- Conditions
- Pain, Procedural, Procedural Anxiety, Sedation Complication
- Trial name
- NCT05267704
- Testing
- Oculus Go Virtual Reality Headset
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Morbid Obesity, Ventilation Therapy; Complications
Intubation of Obese Patients in the Operating Room With or Without Face Mask Ventilation
The aim of the study is to answer a daily question in the operating room: what is the safest technique for intubation of severe/morbid obese patients (BMI 35 or more).
- Trial name
- VENT OR NOT (NCT05930678)
- Testing
- No ventilation with face mask, Ventilation with face mask
- Where
- 13 sites in France
- Volunteers
- 725 people
- Sponsor
- Nantes University Hospital
Obesity in Pregnancy, Labor Complication
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0
Obesity increases the risk of pregnancy complications, including puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- NCT06488781
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 787 people
- Sponsor
- University of Oklahoma
Acute Normovolemic Hemodilution, Cardiac Surgery
Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery
Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion.
- Conditions
- Acute Normovolemic Hemodilution, Cardiac Surgery, Postoperative Complication, Pleth Variability Index
- Trial name
- NCT07466082
- Testing
- acute normovolemic hemodilution, PVI dependant acute normovolemic hemodilution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Vitamin D Deficiency, Vitamin D3 Deficiency
PREDIN: Pregnancy and Vitamin D Intervention Study
Vitamin D deficiency is common among certain risk groups in Sweden, and occurs approximately in every tenth pregnant woman.The aim of the randomized double-blind controlled trial Pregnancy vitamin D intervention (PREDIN) is to…
- Conditions
- Vitamin D Deficiency, Vitamin D3 Deficiency, Pregnancy Complications
- Trial name
- PREDIN (NCT05329428)
- Testing
- Vitamin D Supplementation 20 µg/day, Vitamin D Supplementation 40 µg/day, Usual Antenatal Care
- Where
- Sweden
- Volunteers
- 105 people
- Sponsor
- Göteborg University
Colorectal Surgery, Enhanced Recovery
CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery
In colorectal surgery, one of the most feared complications is anastomotic leak (AL). To limit the consequences of AL, it must be diagnosed as early as possible, before it becomes symptomatic.
- Conditions
- Colorectal Surgery, Enhanced Recovery, CRP Point-of-care Testing Trajectory, Post-operative Complication
- Trial name
- CRP (NCT07464600)
- Testing
- blood sample, Blood taken from a fingertip, Abdomino-pelvic CT scan
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Blood Pressure Determination, Hemodynamic Monitoring
Continuous Vs Intermittent Non Invasive Blood Pressure Monitoring in Preventing Post Operative Organ Failure
Continuous non-invasive arterial pressure monitoring has the potential to decrease the duration of intraoperative hypotension and hypertension compared to conventional intermittent blood pressure monitoring. Chen et al.
- Conditions
- Blood Pressure Determination, Hemodynamic Monitoring, Postoperative Complications
- Trial name
- NiMon (NCT05496322)
- Testing
- Continuous Non Invasive Blood Pressure Monitoring, Intermittent Non Invasive Blood Pressure Monitoring
- Where
- Italy
- Volunteers
- 1,267 people
- Sponsor
- University of Messina
Dysbiosis, Inflammation Gum
Microbiome Alterations With Xylitol (MAX) in Pregnancy
The purpose of this study is to understand if chewing xylitol-gum initiated before 20 weeks of pregnancy and continued until delivery affects the bacteria that are found in the oral and vaginal cavities, signs of inflammation…
- Conditions
- Dysbiosis, Inflammation Gum, Placenta-mediated Pregnancy Complications, Microbioata
- Trial name
- MAX (NCT06329596)
- Testing
- Xylitol gum, Sorbitol gum
- Where
- Malawi
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
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