Clinical trials: Complication
Cervical Cancer
mHealth-supported Telecolposcopy for Cervical Cancer Programs in Low-resource Settings: Evaluation (mIVAA)
The central hypothesis is that use of mIVAA (mobile Inspección Visual con Ácido Acético - Spanish for Visual Inspection with Acetic Acid (VIA)) will increase the proportion of VIA positive women who complete follow-up clinical…
- Trial name
- NCT04421131
- Testing
- Pocket colposcope/Mobile phone camera, mIVAA
- Where
- Peru
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Duke University
Hemorrhage; Complicating Delivery
Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage
To demonstrate that the combined used of oxytocin and misoprostol prevent from post partum haemorrhage better than oxytocin alone, following vaginal birth at 36 to 42 weeks.
- Trial name
- CYTOCINON (NCT01113229)
- Testing
- Misoprostol
- Where
- France
- Volunteers
- 1,721 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Minimal Change Disease
Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease
The purpose of this study is to compare the effectiveness of tacrolimus (prograf) versus prednisolone for the treatment of nephrotic syndrome secondary to minimal change disease.
- Trial name
- MinTAC (NCT00982072)
- Testing
- tacrolimus, prednisolone
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Imperial College Healthcare NHS Trust
Postoperative Pain, Vascular Access Device
Serratus Posterior Superior Intercostal Plane Block in Port Catheter Implantation
This randomized prospective study aims to compare the analgesic efficacy of serratus posterior superior intercostal plane (SPSIP) block and standard local anesthetic infiltration in patients undergoing port catheter implantation.
- Trial name
- NCT07579572
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Local Anesthetic Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Pain, Chronic, Fistula
Effect of Mirror Therapy on the Arteriovenous Fistula Cannulation-related Pain and Anxiety
Pharmacological and non-pharmacological methods are frequently used to reduce cannulation-related pain in patients with fistulas.
- Conditions
- Pain, Chronic, Fistula, Hemodialysis Complication
- Trial name
- NCT06683495
- Testing
- Mirror Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Flu-like Symptoms
Flu-Like Symptoms as a Complication of Botulinum Toxin Therapy
Botulinum toxin (BoNT) has become a revolutionary treatment for many neurological, autonomic, gastrointestinal, genitourinary, and cosmetic disorders.
- Trial name
- NCT01337453
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Christine Hunter
Surgical Site Infection
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to…
- Trial name
- NCT06363877
- Testing
- Povidone-Iodine, Normal Saline
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Loma Linda University
Gastric Cancer (Diagnosis), Postoperative Complications
DeepComp for Prediction of Gastric Cancer Postoperative Complications (DeepComp-Prospective)
Gastric cancer is a leading cause of cancer-related mortality, and radical surgery remains the primary treatment. However, postoperative complications are common and can significantly impact patient recovery and quality of life.
- Trial name
- NCT07401173
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Qun Zhao
Adults Undergoing Otorhinolaryngology Surgery
Intravenous Magnesium Sulphate Versus Dexmedetomidine for Prevention of Emergence Agitation in Adult Otorhinolaryngologic Surgery
The goal of this clinical trial is to learn whether intravenous magnesium sulphate can reduce emergence agitation as effectively as intravenous dexmedetomidine in adult patients undergoing otorhinolaryngology surgery under…
- Trial name
- NCT07544173
- Testing
- Magnesium sulphate, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Universitas Indonesia
Advanced Solid Tumors, Breast Cancer
A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations
This is a Phase 1, open-label study to evaluate the safety and tolerability of ATV-1601 administered orally in adults with AKT1 E17K-mutant, advanced solid tumors and also in HR+/HER2- advanced and metastatic breast cancer, with…
- Conditions
- Advanced Solid Tumors, Breast Cancer, Breast Carcinoma, Breast Neoplasms
- Trial name
- NCT07038369
- Testing
- ATV-1601, ATV-1601 + Fulvestrant
- Where
- 8 sites in United States, France and 2 more
- Volunteers
- 134 people
- Sponsor
- Atavistik Bio, Inc
Pelvic Floor Disorders
Perineal Massage Combined With Hip Joint Training
The goal of this clinical trial is to learn if perineal massage combined with hip joint training works to improve pelvic function (urinary incontinence, constipation and hip motion) in pregnant women.
- Trial name
- NCT06359366
- Testing
- perineal massage combined hip joint training
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Shenzhen Hospital of Southern Medical University
Congenital Adrenal Hyperplasia (CAH)
Fertility And Sexual Function In CAH: CALLIOPE
This is a multicenter study designed to assess the effects of groundbreaking CAH therapies on a spectrum of clinical and biochemical outcomes, with a special emphasis on reproductive and sexual health.
- Trial name
- CALLIOPE (NCT07099456)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Gastroesophageal Reflux, Sleeve Gastrectomy
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
This study aims to determine if preoperative EndoFlip measurement can effectively predict postoperative GERD-related quality of life and lower esophageal acid exposure.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT05690022
- Testing
- sleeve gastrectomy
- Volunteers
- 100 people
- Sponsor
- Laval University
Ovarian Clear Cell Adenocarcinoma, Platinum-Sensitive Ovarian Carcinoma
Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer
This phase II trial tests whether pembrolizumab combined with bevacizumab with or without agonist anti-CD40 CDX-1140 works to shrink tumors in patients with ovarian cancer that has come back (recurrent).
- Conditions
- Ovarian Clear Cell Adenocarcinoma, Platinum-Sensitive Ovarian Carcinoma, Recurrent Endometrial Serous Adenocarcinoma, Recurrent Fallopian Tube Carcinoma
- Trial name
- NCT05231122
- Testing
- Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Bevacizumab, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Roswell Park Cancer Institute
Infertility, Female
Rapid Detection Method for Microorganisms in the Lower Genital Tract
Mycoplasma, chlamydia, and gonococcal infection of the female lower genital tract can lead to infertility and various adverse pregnancy outcomes.
- Trial name
- NCT05678751
- Testing
- lower genital tract microorganisms detection using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shenzhen Second People's Hospital
Postoperative Complications, Appendicitis
Impact of SARS-Cov2 Pandemic on Severity of Perioperative Complications in Patients Undergoing Appendectomy
There are 2 types of surgical procedures to remove the appendix : open appendectomy or laparoscopic appendectomy. About 60000 appendectomies are performed every year in France.
- Conditions
- Postoperative Complications, Appendicitis, COVID-19 Pandemic, Appendicitis With Peritonitis
- Trial name
- SAP-19 (NCT05178251)
- Testing
- appendectomy
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Dietary Modification, Weight Loss
Feasibility of a Postpartum Lifestyle Intervention on the Cardiometabolic Risk Profile of GDM Women
The goal of the study is to investigate the effect of a lifestyle intervention program (adoption of exclusive breastfeeding, healthy diet and regular physical activity) on minimizing postpartum weight retention among women with…
- Conditions
- Dietary Modification, Weight Loss, Physical Activity, Breastfeeding
- Trial name
- DEPART (NCT02872402)
- Testing
- Lifestyle intervention, Active control lifestyle intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laval University
Ovarian Cancer, Ovarian Neoplasms
AZD9150, a STAT3 Antisense Oligonucleotide, in People With Malignant Ascites
Background: Some people with gastrointestinal or ovarian cancer also have ascites. That is free fluid built up in the abdomen. Researchers want to see if a new drug can affect some of the immune cells in the ascites.
- Conditions
- Ovarian Cancer, Ovarian Neoplasms, Ascites, Gastrointestinal Cancer
- Trial name
- NCT02417753
- Testing
- AZD9150
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Solid Tumor, Breast Tumor
Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.
- Conditions
- Solid Tumor, Breast Tumor, Colon Tumor, Malignant, Lung Tumor
- Trial name
- PAVO (NCT05169437)
- Testing
- Niraparib
- Where
- 80 sites in United States
- Volunteers
- 22 people
- Sponsor
- Tempus AI
Postpartum Depression
[Study Evaluating the Efficacy and Safety of a Digital Therapeutic as an Adjunct to TAU in Postpartum Depression]
This study evaluates the efficacy of two digital therapeutics, WB001 and ED001, on depressive symptoms among women diagnosed with postpartum depression.
- Trial name
- NCT05551195
- Testing
- WB001, ED001
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Woebot Health