Clinical trials: Complication, Postoperative
Postoperative Pain
Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty
Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty: Subgroup Analyses of The DEX-2-TKA Randomized Clinical Trial This explorative post-hoc analysis is a substudy of the DEX-2-TKA-trial (NCT03506789)…
- Trial name
- NCT05008367
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 485 people
- Sponsor
- Naestved Hospital
Lymphedema of Upper Arm
Responsiveness of Outcome Scales in Breast Cancer Related Lymphedema
The aim of this study is to investigate and compare responsiveness of current lymphedema assessment scales validated in Turkish.
- Trial name
- NCT04138667
- Testing
- complex decongestive therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
- Trial name
- NCT05574400
- Testing
- Dextrose Water, Caffeine citrate
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Postoperative Nausea and Vomiting
Famotidine Versus Placebo in Emergency Pediatric Surgery As a Risk to Postoperative Nausea and Vomiting
The aim of this study is to evaluate the difference of the gastric volume by quantitative measurements of gastric antrum preoperatively and postoperatively by using 5mg famotidine versus placebo as a risk factor of PONV.
- Trial name
- NCT06211088
- Testing
- famotidine plus10ml normal saline, 10ml normal saline
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Post Operative Pain, Impacted Third Molar Tooth
Jaw Muscle Pain Post Wisdom Molar Surgery
The proposed design is a triple-blind, placebo-controlled randomized prospective phase II trial to assess the feasibility of employing the Temporo-masseteric Nerve Block (TMNB) injection to decrease jaw muscle pain, overall pain…
- Conditions
- Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain
- Trial name
- NCT07094542
- Testing
- Temporo-masseteric Nerve Block Injection, Oral Pain Medications only
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Incisional Hernia of Midline of Abdomen
Barbed Suture for Emergency Midline Laparotomy Closure
Urgency surgeries are often performed in a stressful setting with critical patient involved. In this context, laparotomy closure can sometimes be the most neglected part of the procedure.
- Trial name
- BAROTOMY (NCT05351970)
- Testing
- Barbed
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Postoperative Complications
ERAS Protocol on the Incidence of Postoperative Complications Following Intestinal Surgery
Enhanced recovery after surgery (ERAS) was first proposed by Kehlet in Copenhagen Denmark, this is a new concept for the integration of the latest study of the surgical, anesthesia, and nursing.
- Trial name
- NCT02728973
- Testing
- ERAS program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Narcotic Consumption, Pain
Motorized Continuous Cold Therapy Versus Standard Post-op Icing Protocol for Two Foot and Ankle Procedures
This study will compares differences in pain level, narcotic consumption, wound healing, patient satisfaction in patients randomized to the Iceman® cold pack therapy system (djOrtho, Inc) versus those who use ice.
- Conditions
- Narcotic Consumption, Pain, Wound Healing, Patient Satisfaction
- Trial name
- NCT00950183
- Testing
- Iceman® Cold Therapy unit (djOrtho), Ice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Bladder Neck Obstruction, Bladder Outlet Obstruction
Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture
Autologous adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion from a portion of the fat harvested from the patient's front abdominal wall.
- Conditions
- Bladder Neck Obstruction, Bladder Outlet Obstruction, Benign Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
- Trial name
- NCT02869061
- Testing
- Liposuction, Transurethral bladder neck resection., ADRC
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Postoperative Nausea and Vomiting
Predictive Model for PONV for Patient Received Gynecological Laparoscopic Surgery
This is a prospective study to dynamically predict the risk of PONV in patients undergoing gynecologic laparoscopic surgery.
- Trial name
- NCT05757986
- Testing
- The presence of nausea and vomiting within 24 hours after surgery
- Where
- China
- Volunteers
- 659 people
- Sponsor
- Jiang Liu
Complication of Surgical Procedure, Complication of Anesthesia
A Novel Classification for the Assessment and Grading of Unexpected Events in Pediatric Surgery: The Clavien-Madadi Classification
Postoperative adverse events may be associated with substantial morbidity and mortality. However, inconsistent definitions of complications and unexpected events have limited accurate analysis of surgical outcomes.
- Conditions
- Complication of Surgical Procedure, Complication of Anesthesia, Complication,Postoperative, Complication of Medical Care
- Trial name
- ComPedS (NCT05277441)
- Testing
- Novel severity grading system of unexpected events in pediatric surgery
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Hannover Medical School
Pelvic Organ Prolapse (POP), Postoperative Pain
Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management
The goal of this clinical trial is to determine whether suzetrigine, when added to standardized multimodal postoperative analgesia improves pain control and reduces opioid consumption after apical suspension surgery for pelvic…
- Conditions
- Pelvic Organ Prolapse (POP), Postoperative Pain, Urogynecology
- Trial name
- SUSI (NCT07856654)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Aditi Talkad
Cancer Surgery, Intraoperative Hypothermia
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor.
- Conditions
- Cancer Surgery, Intraoperative Hypothermia, Targeted Temperature Management, Postoperative Delirium
- Trial name
- NCT06256354
- Testing
- Routine thermal management, Target temperature management
- Where
- 36 sites in China
- Volunteers
- 3,992 people
- Sponsor
- Peking University First Hospital
Sepsis, Vasoplegia
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery.
- Trial name
- JEDI-2 (NCT06613256)
- Testing
- Endothelial cell biopsy
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Prosthesis-related Infections
Evaluation of the Efficacy and Safety of Suppressive Therapy With DALBAVANCINE in Device Infections
The aim of this retrospective observational study is to evaluate the efficacy of antibiotic therapy with dalbavancin in patients presenting with infection on prosthetic devices.
- Trial name
- DALBASAT (NCT06089044)
- Testing
- Dalbavancin Injection
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Tourcoing Hospital
Mortality, Complication, Postoperative
Periinterventional Outcome Study in the Elderly
The POSE study will predict critical stages and outcome in a large sample of all surgical and non-surgical interventional patients ≥80 years of age in Europe.
- Trial name
- POSE (NCT03152734)
- Testing
- Surgical or non-surgical intervention
- Where
- 177 sites in Austria, Belgium and 18 more
- Volunteers
- 9,500 people
- Sponsor
- Mark Coburn
Postsurgical Pain
A Trial of SHR0410 Injection in Postsurgical Pain Management
The study is being conducted to evaluate the efficacy, safety of SHR0410 Injection and to explore the reasonable of SHR0410 Injection for Pain Management after Orthopaedic Surgery.
- Trial name
- NCT05394402
- Testing
- SHR0410 Injection
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant
Breast-implant ASsocIated anaplastIc Large Cell Lymphoma and CApsular Contracture
BASILICA is a UK NIHR Biomedical Research Centre funded study recruiting patients at The Royal Marsden NHS Foundation Trust. The study aims to obtain blood and tissue samples from patients with breast implant-associated…
- Conditions
- Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant, Breast Implant; Complications
- Trial name
- BASILICA (NCT05017337)
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Post Operative Cardiac Surgery, ARDS
PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With Hypoxemic Respiratory Failure
The purpose of this study is to: Compare PEEP level selected by individualized PEEP titration by electrical impedance tomography and PEEP level routinely used in post-operative cardiac patients with Hypoxemic Respiratory Failure…
- Conditions
- Post Operative Cardiac Surgery, ARDS, Hypoxemic Respiratory Failure
- Trial name
- NCT02056977
- Testing
- Titration, control
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Postoperative Nausea and Vomiting, Acupressure
The Efficacy of P6 Acupressure in Reducing Postoperative Nausea and Vomiting in Patients Undergoing Craniotomy
The aim of this study is to investigate if P6 acupressure may reduce postoperative nausea and vomiting in neurosurgical patients undergoing craniotomy.
- Conditions
- Postoperative Nausea and Vomiting, Acupressure, Craniotomy
- Trial name
- NCT01617837
- Testing
- P6 acupressure band
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University