Clinical trials: Complex Anal Fistula
Anal Fistula
Anal Fistula Plug Versus Endorectal Advancement Flap
The purpose of this study is to determine whether anal fistula plug or endorectal advancement flap is more successful in the treatment of anal fistulas and compared both procedures with regards to cost.
- Trial name
- AFPERAF (NCT01931371)
- Testing
- Anal Fistula Plug, Endorectal Advancement Flap
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- University of Zurich
Anal Fistula
Endoscopic Treatment of Complex Anal Fistulas
This is a randomised controlled trial to evaluate the outcome of treatment of complex perianal fistula by Video-assisted anal fistula treatment (VAAFT) compared to fistulectomy and sphincter reconstruction as standard surgical…
- Trial name
- VAAFT (NCT02585167)
- Testing
- operation, VAAFT
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- University of Southern Denmark
Anorectal Fistula
Effect of Short Term Versus Long Term Treatment With Seton Prior to LIFT Surgery for Complex Anal Fistula
The aim of this study is to compare short term (3 week) with long term (6 months) treatment with seton prior to LIFT surgery. The main end-points are recurrence rates and complication rates after surgery.
- Trial name
- NCT01913249
- Testing
- LIFT
- Where
- Norway
- Sponsor
- Sykehuset Innlandet HF
Anal Fistula
RCT on LIFT Versus Modified Parks Technique Versus Two-Stage Seton
LIFT is a sphincter-saving procedure that is based on the concept of secure closure of the internal opening and concomitant removal of infected cryptoglandular tissue in the intersphincteric plane.
- Trial name
- NCT04377542
- Testing
- LIFT, Parks, Seton
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Mansoura University
Crohn's Disease, Anal Fistula
Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease.
The purpose of this study is to asses the safety and efficacy of adipose-derived adult stem cells from healthy donnors for treatment of complex perianal fistulas in Crohn's disease.
- Trial name
- NCT01372969
- Testing
- Cx601
- Where
- 6 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Tigenix S.A.U.
Anal Fistula
Ethibond Suture vs Vessel Loop as Draining Seton for Complex Anal Fistulas
Drainage seton is usually placed for long-term control of symptoms, and hence it has to be effective in drainage of infection, durable, and comfortable to the patients.
- Trial name
- NCT05933343
- Testing
- Ethibond suture, Vessel loop
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Fistula Perianal
Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula
The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease.
- Trial name
- NCT06568653
- Testing
- exosome, routine conventional fistulotomy
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Anal Fistula, Crohn Disease
Stem Cells Treatment of Complex Crohn's Anal Fistula
A pilot study to investigate the safety and feasibility of stem cells treatment of complex anal fistula in patients with Crohn's disease.
- Trial name
- fistula (NCT03466515)
- Testing
- stem cells injection
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Southern Denmark
High Complex Anal Fistula
Decompression and Drainage Seton in the Treatment of High Complex Anal Fistula
This study aimed to compare the efficacy of the decompression and drainage seton (DADS) and cutting seton (CS) in the treatment of high complex anal fistula.
- Trial name
- NCT05087407
- Testing
- Decomprssion and drainage seton, Cutting seton
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Complex Anal Fistula
Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula
Anal abscess-fistula disease is of common occurrence and has a significant impact on the quality of life of affected individuals.
- Trial name
- NCT01612195
- Testing
- Anal fistula plug
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Anal Fistula
Treatment of Transsphicteric Fistula-in-ano by Method of Laser Thermoobliteration(FiLaC™).
This is a randomized, controlled, parallel study to compare the results of treatment for patients with transsphincteric fistulas-in-ano.
- Trial name
- NCT03690934
- Testing
- Fistula-tract laser closure (FiLAC™), Monopolar coagulation of fistulous tract
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Crohn Disease, Perianal Fistula
Micro-fragmented Adipose Tissue and Complex Crohns' Anal Fistulas
The study aims to evaluate safety, feasibility and effectiveness of local injections of autologous and micro-fragmented adipose tissue obtained with the Lipogems® system in patients with refractory complex fistulizing perianal…
- Trial name
- NCT03555773
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Anal Fistula
Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease
Anal fistula is defined as an abnormal communication between the anal canal and the perianal skin. Adipose-derived stem cells are a new therapy for the closure of these fistulas.
- Trial name
- FATT1 (NCT00475410)
- Testing
- ASCs (Cx401, company code), Fibrin adhesive
- Where
- 10 sites in Germany, Spain and 1 more
- Volunteers
- 214 people
- Sponsor
- Tigenix S.A.U.
Perianal Fistula
This Study Compares the Conventional Cutting Seton Technique and a GLUBRAN®-Coated Seton in High Perianal Fistula Treatment. The Study Aims to Determine Whether the GLUBRAN®-Coated Seton Improves Healing, Reduces Postoperative Pain and Recurrence, and Better Preserves Anal Continence.
High anal fistula is a complex anorectal condition that can cause persistent pain, purulent discharge, recurrent infection, and a significant reduction in quality of life.
- Trial name
- NCT07676825
- Testing
- Glubran-coated Seton, Seton
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Kasr El Aini Hospital
Rectal Fistula
Photodynamic Therapy in Anal Fistula
Objective: Validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula. Methods: Prospective observational study including patients treated for complex anal fistula who…
- Trial name
- NCT03864718
- Testing
- photodynamic therapy
- Volunteers
- 49 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Anal Fistula
Long-term Follow-up of Anal Fistula Plug
Aim of the study is to evaluate long-term success rate of Biodesign® anal fistula plug for treatment of complex trans-sphincteric anal fistulas.
- Trial name
- NCT03961984
- Testing
- Biodesign® anal fistula plug
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane