Clinical trials: Competency
Heart Failure
Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
- Trial name
- COMPETENCE (NCT01187368)
- Testing
- EVAHEART Left Ventricular Assist System (LVAS), HeartMate 3
- Where
- 12 sites in United States
- Volunteers
- 399 people
- Sponsor
- Evaheart, Inc.
Hysteroscopy
Role of Virtual Reality Simulators in Basic Hysteroscopy Training Competence
Evaluation the efficacy of Virtual Reality simulator training in improving basic gynecological hysteroscopic skills and assess training levels in Ob/Gyn residents, as compared to others with previous hysteroscopic experience.
- Trial name
- NCT05540379
- Testing
- Virtual Reality Training
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Egymedicalpedia
Mental Competency, Mental Fatigue
Pharmaton Upgrade in Improving Mental Performance and Decreasing Fatigue
To assess the efficacy and safety of Pharmaton? PHL 00749 in improving cognitive function and allevi ating mental and physical stress in healthy male and female subjects leading demanding lifestyles.
- Trial name
- NCT00144235
- Testing
- Pharmaton PHL 00749
- Where
- United Kingdom
- Volunteers
- 412 people
- Sponsor
- Boehringer Ingelheim
Malaria (Plasmodium Falciparum)
Challenge Trial of PfSPZ-LARC2 Vaccine in Burkina Faso
This is a randomized, double-blind, placebo-controlled, Phase 1 trial of Plasmodium falciparum (Pf) late liver stage-arresting replication-competent (LARC) sporozoite (SPZ) malaria vaccine (Sanaria® PfSPZ-LARC2 Vaccine)…
- Trial name
- BFSPZL3 (NCT07730177)
- Testing
- PfSPZ-LARC2 Vaccine, PfSPZ Challenge, Normal Saline
- Where
- Burkina Faso
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Anthrax Infection
A Phase 1 Ascending Dose Study to Assess the Safety and Immunogenicity of Adenovirus Anthrax Vector Candidate Vaccines
The purpose of this study is to evaluate 2 vaccine candidates against anthrax compared to the positive (vaccine) control as studied in normal healthy volunteers.
- Trial name
- NCT01979406
- Testing
- AVA, Ad4-PA-1, Ad4-PA-GPI-1
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Female Infertility, Oocyte Competence
Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)
The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo…
- Conditions
- Female Infertility, Oocyte Competence, Mitochondria, Recurent Implantation Failures
- Trial name
- NCT07066267
- Testing
- Experimental
- Where
- Sri Lanka
- Volunteers
- 20 people
- Sponsor
- Sunkaky Medical Cooperation
Bird Flu, Influenza
Safety and Immunogenicity of Replication-Competent Adenovirus 4-vectored Vaccine for Avian Influenza H5N1
The purpose of this study is to compare the safety and immunogenicity over a 9-month period of five different dosages of Ad4-H5-Vtn in volunteers (Vaccinees) who receive three doses of the study vaccine or placebo.
- Trial name
- NCT01006798
- Testing
- Ad4-H5-Vtn, Sanofi Pasteur Influenza Virus Vaccine, H5N1
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Heart Failure
Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction
This study will look at how pacing your heart may assist your daily activities and how you are feeling.
- Trial name
- RESET (NCT00670111)
- Testing
- Insignia Plus / Ultra (Guidant/Boston Scientific)
- Where
- 5 sites in United States
- Volunteers
- 32 people
- Sponsor
- Boston Scientific Corporation
Malignant Pleural Mesothelioma
Intrapleural Administration of HSV1716 to Treat Patients With Malignant Pleural Mesothelioma.
HSV1716, an oncolytic virus, is a mutant herpes simplex virus (HSV) type I, deleted in the RL1 gene which encodes the protein ICP34.5.
- Trial name
- 1716-12 (NCT01721018)
- Testing
- HSV1716 Intra-pleural delivery
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Virttu Biologics Limited
Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV
Phase I Study of TBI-1401(HF10) Plus Chemotherapy in Patients with Unresectable Pancreatic Cancer.
The purpose of this study is to determine the recommended dose of TBI-1401(HF10) treatment in combination with chemotherapy (Gemcitabine + Nab-paclitaxel or TS-1) in patients with stage III or IV unresectable pancreatic cancer.
- Trial name
- NCT03252808
- Testing
- TBI-1401(HF10), Gemcitabine, Nab-paclitaxel
- Where
- 8 sites in Japan
- Volunteers
- 36 people
- Sponsor
- Takara Bio Inc.
Knowledge, Attitudes, Practice, Burnout, Caregiver
Online Training & Certification for Competency in Dementia Friendly Hospital Care
This research study will evaluate the CARES Dementia-Friendly Hospitals online training and certification program for Allied Health Workers (nursing assistants, dietary aides, housekeeping employees, hospital transporters…
- Conditions
- Knowledge, Attitudes, Practice, Burnout, Caregiver, Job Satisfaction
- Trial name
- NCT04182282
- Testing
- CARES Dementia-Friendly Hospitals Online Training and Certification Program
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- HealthCare Interactive, Inc.
Wound - in Medical Care
A Study to Evaluate the Benefits of Using a Range of Wound Care Products From a Single Manufacturer
This study is designed to investigate whether the adoption of the use of a range of wound care products from a single manufacturer makes training in appropriate product selection more effective and results in more accurate…
- Trial name
- NCT02937909
- Testing
- Use of wound care products from a single manufacturer
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- BSN Medical Ltd. UK
Metastatic Breast Cancer, Advanced Breast Cancer
Implementing Patients´ Competence in Oral Breast Cancer Therapy
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided…
- Trial name
- IMPACT (NCT04030728)
- Volunteers
- 212 people
- Sponsor
- Onco Medical Consult GmbH
Long Term Safety Following GM T Cell Therapy
A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T Cells
This is a prospective study for the Long-Term Follow-Up (LTFU) of safety and efficacy of all participants exposed to gene modified (GM) T cell therapy in accordance with Health Authorities' guidance for participants treated with…
- Trial name
- NCT06798298
- Testing
- Non-interventional
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Regeneron Pharmaceuticals
Malaria (Plasmodium Falciparum)
Field Trial of PfSPZ-LARC2 Vaccine in Burkinabe Adults
This is a phase 2 clinical trial of a Plasmodium falciparum (Pf) late liver stage-arresting replication-competent (LARC) sporozoite (SPZ) vaccine (Sanaria® PfSPZ-LARC2 Vaccine) that will assess field efficacy in Africa.
- Trial name
- BFSPZL2 (NCT07385287)
- Testing
- Genetically attenuated PfSPZ Vaccine, Normal Saline (0.9% Sodium Chloride)
- Where
- Burkina Faso
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Healthy Volunteer, HIV Vaccine
Study to Evaluate the Safety and Immunogenicity of an Oral HIV Vaccine in Healthy, HIV-uninfected Adults
The purpose of this study is to test experimental human immunodeficiency virus (HIV) vaccines that use an adenovirus vector. The adenovirus vector may help the vaccines stimulate an immune response.
- Trial name
- NCT02771730
- Testing
- Ad4-mgag, Ad4-EnvC150, AIDSVAX B/E
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Clinical Competence, Medical Education
Intervention for Medical Student to Promote Cervical Cancer Screening Among Latinx Transmasculine Individuals
The team aims to test the effectiveness of an intervention to increase gender-affirming cervical cancer prevention behaviors targeted at medical students studying in Puerto Rico and Florida.
- Conditions
- Clinical Competence, Medical Education, Cervical Cancer Screening
- Trial name
- CC-Trained (NCT06844097)
- Testing
- Cervical Cancer Trans Inclusive Education (CC-TRAINED) Module, Disaster Preparedness Course
- Volunteers
- 60 people
- Sponsor
- Ponce Medical School Foundation, Inc.
Stigmatization, Clinical Competence
Intervention to Reduce Serious Mental Illness and Suicide Stigma Among Medical Students
The team aims to develop and test the efficacy of a serious mental illness (SMI) and suicide ideation and attempt (SIA) stigma reduction intervention for medical students.
- Trial name
- NCT05325320
- Testing
- SMI/SIA Stigma Reduction Intervention, Disaster Preparedness Course
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ponce Medical School Foundation, Inc.
Melanoma Stage III, Melanoma Stage IV
A Study of Combination with TBI-1401(HF10) and Ipilimumab in Japanese Patients with Unresectable or Metastatic Melanoma
The purpose of this study is to determine if TBI-1401(HF10) in combination with ipilimumab is effective in Japanese patients with stages IIIB, IIIC, or IV unresectable or metastatic melanoma.
- Trial name
- NCT03153085
- Testing
- TBI-1401(HF10), Ipilimumab
- Where
- 12 sites in Japan
- Volunteers
- 28 people
- Sponsor
- Takara Bio Inc.
Brain Cancer, Central Nervous System Diseases
DNX-2401 (Formerly Known as Delta-24-RGD-4C) for Recurrent Malignant Gliomas
The goal of this clinical research study is to find the highest tolerable dose of DNX-2401 that can be injected directly into brain tumors and into the surrounding brain tissue where tumor cells can multiply.
- Trial name
- NCT00805376
- Testing
- DNX-2401, Tumor Removal
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- DNAtrix, Inc.