Clinical trials: Comparative Effectiveness
Dental Anxiety
Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie
The vicious circle of dental anxiety impacts major aspects of a child's quality of life. Hypnosis using distraction is one of the most common non-pharmalogical techniques in behavior and pain management in pediatric dentistry.
- Trial name
- HYPNOSEDENT (NCT05167331)
- Testing
- Nitrous Oxide inhalation, Dispositif de RV - HYPNO VR
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Rheumatoid Arthritis, JAK Inhibitor
Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
The administration of Janus kinase (JAK) inhibitors as well as biological disease-modifying anti-rheumatic drugs has dramatically improved even the clinical outcomes in rheumatoid arthritis (RA) patients with inadequate response…
- Conditions
- Rheumatoid Arthritis, JAK Inhibitor, IL-6 Inhibitor, Musculoskeletal Ultrasound
- Trial name
- TRANSFORM (NCT05090410)
- Testing
- filgotinib 200mg/day, subcutaneous tocilizumab 162mg/biweekly
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Atsushi Kawakami
Hepatitis B
LT F-up Study 16-20 Yrs After Vaccine Dose of Hepatitis B With/Without HBIg in Newborns to HBeAg+ Mothers
To evaluate the persistence of anti-HBs antibodies up to 16, 17, 18, 19 and 20 years after administration of the first dose of the study vaccine.
- Trial name
- NCT00240526
- Testing
- Engerix™ -B, Hepatitis B immunoglobulin (HBIg)
- Where
- Thailand
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Wound Debridement
A Comparative Study of the Efficacy and Safety of Two Methods in the Treatment of Skin Wounds
This study will compare the experimental group (debridement assisted by surgical microscope + VSD) and the control group (debridement under naked-eye observation + VSD) in terms of the rate of change in BWAT scores at one week…
- Trial name
- NCT07323615
- Testing
- microscopic
- Volunteers
- 98 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Burn Injuries
Mepilex Ag Versus Silver Sulfadiazine in Children and Adults With Burn Injuries.
The purpose is to compare time to healing using absorbent foam silver dressing (Mepilex Ag) compared to a silver sulfadiazine (SSD) 1% cream in the treatment of partial thickness burn injuries.284 in-patients in 8-12 centres in…
- Trial name
- NCT01439074
- Testing
- Mepilex Ag, Silver Sulphadiazine Ag cream
- Where
- 9 sites in China
- Volunteers
- 162 people
- Sponsor
- Molnlycke Health Care AB
Hip Fractures
Comparative Study to Evaluate the Efficacy of Ultrasound-Guided Pericapsular Nerve Group (PENG) Block Versus Fascia Iliaca Compartment (FIC) Block on the Postoperative Analgesic Effect in Patients Undergoing Hip Surgeries Under Spinal Anesthesia.
Fractures in and around the hip are quite common irrespective of both the young and elderly population groups and are associated with extreme pain.
- Trial name
- NCT05751291
- Testing
- Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sohag University
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Prostate Cancer
Decision Support Interventions (DESI) for Prostate Cancer Screening and Treatment - Study 2
Researchers in this study will determine whether providing decision support interventions (DESIs) to men with low risk prostate cancer improves their decision-specific knowledge and alters their treatment decisions.
- Trial name
- NCT01244568
- Testing
- Prostate cancer treatment DESI
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- University of North Carolina, Chapel Hill
Myopia, Cost-effectiveness Analysis
Comparing Myopia Treatments in Youth: Defocus Spectacles, Glasses, and Ortho-K
The research project titled "A Comparative Study on the Clinical Efficacy, Quality of Life, and Cost of Use of Peripheral Defocus Spectacles, Frame Glasses, and Orthokeratology Lenses in Myopic Children and Adolescents" aims to…
- Conditions
- Myopia, Cost-effectiveness Analysis, Quality of Life
- Trial name
- NCT06278974
- Where
- China
- Volunteers
- 90 people
- Sponsor
- He Eye Hospital
Venous Thromboembolism
the Effectiveness of Different Risk Scales In Predicting VTE in Respiratory Inpatients
To compare the predictive effectiveness of the Caprini risk assessment model, the Padua risk assessment model and the VTE risk assessment in medical patients mentioned in the 2018 edition of the Guidelines for the diagnosis…
- Trial name
- NCT04963374
- Testing
- risk evolution scale
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Phantom Limb Pain
Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in AKAP
Limb amputation results in many types of pain, including localized pain at the stump and projected pain experienced by the patient in the location where the amputated limb used to be, known as phantom limb pain (PLP).
- Trial name
- NCT06428123
- Testing
- Mirror Therapy on present Lower Limb, Mental Imagery on present Lower Limb
- Where
- 2 sites in Pakistan
- Volunteers
- 24 people
- Sponsor
- Superior University
Self-efficacy and Perceived Stress Among Physiotherapy Interns in Clinical Training
Comparative Study of Self-Efficacy and Perceived Stress Among Physiotherapy Interns in Turkey and Egypt
This cross-sectional comparative study aims to assess and compare the self-efficacy and perceived stress levels among physiotherapy interns in Turkey and Egypt.
- Trial name
- SEPS-PT (NCT07249580)
- Testing
- Online Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medipol University
Diabetic Foot Ulcer, Deep Diabetic Foot Ulcer
Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers
Diabetes-related foot ulcers (DFUs) are a leading cause of hospitalization and amputation worldwide, and account for 33% of all direct costs of diabetes care in the US.
- Trial name
- NCT03476876
- Testing
- Dermacell, Integra
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Baylor College of Medicine
Cerebral Palsy
Cerebral Palsy Hip Outcomes Project - International Multi-centre Study
The primary purpose of the project is to evaluate the effectiveness of different intervention strategies to prevent or relieve symptoms associated with hip instability in children with severe cerebral palsy, using the validated…
- Trial name
- NCT01987882
- Where
- 27 sites in United States, Australia and 8 more
- Volunteers
- 500 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
HIV Infections
Efficacy and Safety Study of Miconazole Lauriad to Treat Oropharyngeal Candidiasis in HIV Patients
The purpose of this study is to evaluate the clinical cure of miconazole Lauriad 50 mg (1x50mg) Bioadhesive buccal tablets compared with clotrimazole troches (5x10mg) after 14 days of treatment (at the test of cure visit, at Day…
- Trial name
- NCT00390780
- Testing
- miconazole Lauriad, Clotrimazole
- Where
- 27 sites in United States, Canada
- Volunteers
- 578 people
- Sponsor
- Valerio Therapeutics
de Novo Heart Failure
Comparative Effectiveness of Entresto (Sacubitril/Valsartan) Versus ACEi/ARB in de Novo Heart Failure Patients
This was a non-interventional retrospective cohort study of de novo heart failure with reduced ejection fraction (HFrEF) patients (aged ≥18 years) commencing first-line treatment on either sacubitril/valsartan or commencing or…
- Trial name
- NCT05963282
- Where
- United States
- Volunteers
- 9,870 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Disease, Chronic Obstructive
A Randomized Comparative Effectiveness Research Trial of Three Treatments for COPD Patients
The aim of this study is to compare the effectiveness and economic evaluation of three treatments for Chronic Obstructive Pulmonary Disease (COPD) patients: one, conventional medicine based on 2011 Global Initiative for Chronic…
- Trial name
- NCT01836016
- Testing
- Salbutamol (Ventolin®), Formoterol (Oxis Turbuhaler®), Salmeterol / fluticasone (Seretide®)
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Breast Cancer Patients
Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Breast Cancer Patients
To Evaluate the effect of addition of Dexmedetomedine to ultrasound guided modified Pecs block on post operative analgesia \& stress response in patient undergoing modified radical mastectomy.
- Trial name
- NCT03046238
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Ventilation
BASKA Laryngeal Mask Airway in Either Volume or Pressure Controlled Ventilation in Laparoscopic Cholecystectomy
this study will be undertaken to compare the efficacy of BASKA mask in volume controlled and pressure controlled ventilation in laparoscopic cholecystectomy.
- Trial name
- NCT03610126
- Testing
- volume controlled ventilation, pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Assiut University
Trauma Exposure, Trauma
Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress
The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological…
- Conditions
- Trauma Exposure, Trauma, Trauma and Stressor Related Disorder, Mental Health Functioning
- Trial name
- NCT07483333
- Testing
- Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Anthony Vesco