Clinical trials: Comparative Effectiveness
Alveolar Ridge Preservation, Tooth Loss
Volumetric Efficacy of Alveolar Ridge Preservation
The goal of this clinical trial is to compare the effectiveness of four post-extraction socket management approaches in preserving alveolar ridge dimensions following tooth extraction in adults requiring implant-supported…
- Conditions
- Alveolar Ridge Preservation, Tooth Loss, Tooth Extraction, Tooth Extraction Site Healing
- Trial name
- ARP (NCT07812883)
- Testing
- Spontaneous Healing, d-PTFE Membrane, Leukocyte- and Platelet-Rich Fibrin (L-PRF)
- Where
- Chile
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Dental Caries in Children
Comparative Study Between Smart Bur II and Traditional Carbide Bur in Selective Removal of Caries in Permanent Molars
A more biological and conservative technique of caries removal has emerged with minimally invasive restorative dentistry's advent. As a result, Smart Burs II has become a self-limiting, sensitive tool for removing caries.
- Trial name
- NCT06187259
- Testing
- caries removal by carbide bur, caries removal by polymer bur II
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Irritable Bowel Syndrome, GI Disorders
GUT LINK: A Study of a Care Pathway Across Primary and GI Specialty Care
It can be challenging for Primary Healthcare Providers (PHCPs) to differentiate between IBS and more serious illnesses involving the GI tract, such as Crohn's disease, ulcerative colitis, or cancer.
- Trial name
- NCT05725954
- Testing
- GUT LINK SmartPath
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael Stewart
Root Canal Infection
Efficacy of Chlorhexidine as a Final Irrigant in Single-visit Root Canal Treatment
Ninety asymptomatic maxillary anterior teeth with periapical lesions were treated in single versus multiple visit root canal treatment.
- Trial name
- NCT03336970
- Testing
- EDTA, NaOCl, CHX
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Çalışkan
Aesthetic, Aesthetic Rejuvenation
Clinical Investigation of the Medical Device "Alexa Volume" for Correction of Midface Volume Loss
This is a post-marketing, open-label, non-comparative, multi-center clinical investigation to evaluate the effectiveness and safety of the medical device "Alexa Volume" (DIACO BIOFARMACEUTICI S.r.l., Italy), based on cross-linked…
- Conditions
- Aesthetic, Aesthetic Rejuvenation, Midface Volumization, Age-related Volume Deficit in the Mid-face
- Trial name
- NCT06984419
- Testing
- Cross-linked hyaluronic acid dermal filler
- Where
- 4 sites in Poland, Ukraine
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institute Hyalual GmbH
Type 2 Diabetes Mellitus
Study to Test Use of a Decision Aid in a Clinical Visit to Help Patients Choose a Diabetes Medication
The goal of this study is to test the relative merits of a decision aid for diabetes medications that we have developed - Diabetes Medication Choice Cards- versus usual care in translating comparative effectiveness research (CER)…
- Trial name
- TRICEP (NCT01293578)
- Testing
- Diabetes Medication Choice Cards
- Where
- 6 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Myelogenous Leukemia
Randomized Study of Haploidentical Hct and Subsequent Donor nk Cell Infusion in High-risk AML and MDS
This is a single center, open label, random comparison phase 2b study. The primary objective of this study is, by random comparison, to assess the anti-leukemia effect of allogeneic, donor-derived natural killer (NK) cells…
- Trial name
- DNKI-4 (NCT02477787)
- Testing
- allogeneic, donor-derived NK cells
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Suppression of Ovulation
Minimal Effective Dose of Nomegestrol Acetate Inhibiting the Ovulation in Women Receiving Estradiol
The aim of the present study was to evaluate the ability of several doses of NOMAC in combination with E2 to inhibit ovulation and to assess changes in the gonadotropin and ovarian hormone profiles, in comparison to a control…
- Trial name
- NCT01361958
- Testing
- NOMAC
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theramex
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Atrial Fibrillation
The Comparative Efficacy of the Zio Patch vs Implantable Loop Recorder in Atrial Fibrillation
The aim of our study is to investigate if LTCM's are superior to implantable loop recorders in detecting atrial fibrillation after pulmonary vein isolation.
- Trial name
- ALERT-AF (NCT02954380)
- Testing
- Zio
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Gallstones, Pain
Comparison of the Efficacy of Different Analgesic Strategies for Pain Control After Laparoscopic Cholecystectomy (LC)
The investigators collected 200 patients underwent safe uncomplicated laparoscopic cholecystectomy, then different strategies of pain control are used.
- Trial name
- Randomized (NCT07897435)
- Testing
- Low pneumoperitoneum, Local anaesthetic instillation to gallbladder bed
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Morton Neuroma
Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma
Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult…
- Trial name
- NCT05501262
- Testing
- Cryoablation, Nerve block
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Posture, Neck Disorder
Comparative Analysis of Artificial Intelligence-Generated and Studio-Based Reformer Pilates Interventions for Forward Head Posture
Posture is the alignment of body segments. While ideal posture places minimal stress on the joints, poor posture increases joint stress.
- Trial name
- NCT07205835
- Testing
- ChatGPT Exercise Group, Clinical Pilates Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Chronic Diarrhea
Comparative Evaluation of Herbal and Allopathic Drugs for the Treatment of Chronic Diarrhea
Revival of significance and the emergent market of herbal medicinal products necessitate strong commitment by the stakeholders to safeguard the end users.
- Trial name
- HA (NCT02642250)
- Testing
- Metronidazole, Entoban
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shifa Ul Mulk Memorial Hospital
LGBT Health, Cultural Competency
Comparative Effectiveness Research to Improve the Health of Sexual and Gender Minority Patients Through Cultural Competence and Skill Training of Community Health Center Providers and Non-clinical Staff
The primary goal of this PCORI proposal is to evaluate the impact of enhanced provider and clinical staff training to address the health disparities of SGM CHC patients to ultimately improve their health outcomes because CHCs are…
- Conditions
- LGBT Health, Cultural Competency, Education, Sexual Orientation
- Trial name
- PCORI-SOGI (NCT03554785)
- Testing
- Clinician and Non-clinician staff training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Ultrasound Guided Nerve Block, Anesthesia , Analgesia
Comparative Study Between Ultrasound Guided Regional Anesthesia for Awake Tympanoplasty Surgery vs General Anesthesia
The aim of this study to evaluate efficacy of ultrasound guided regional anesthesia in performing awake tympanoplasty surgery versus traditional general anesthesia
- Trial name
- NCT07275450
- Testing
- Ultrasound-guided regional anesthesia group, Control group
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Wound Complication
Cesarean Skin Incision Trial
The purpose of this study is to determine if there is a difference between Pfannenstiel and midline vertical skin incision at time of cesarean section in preventing wound complications in the morbidly obese patient.
- Trial name
- C-SIT (NCT01897376)
- Testing
- Pfannenstiel incision, vertical skin incision
- Where
- 2 sites in United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Influenza, Influenza, Human
Baloxavir Versus Oseltamivir for Nursing Home Influenza Outbreaks
Influenza outbreaks are a prevalent event in nursing homes (NHs). We will study baloxavir compared to oseltamivir when used for influenza prophylaxis when facilities identify an index incident case of influenza.
- Conditions
- Influenza, Influenza, Human, Influenza -Like Illness
- Trial name
- NCT05012189
- Testing
- Oseltamivir, Baloxavir
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC
Depressive Disorder
European Comparative Effectiveness Research on Internet-based Depression Treatment
To compare the clinical impact and cost-effectiveness of blended Cognitive Behavioural Therapy (CBT) for adults with major depressive disorder (MDD) with treatment as usual (TAU).
- Trial name
- E-COMPARED (NCT02542891)
- Testing
- Blended CBT, Treatment as Usual (TAU)
- Where
- 10 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
AI (Artificial Intelligence), Large Language Model
OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice
OpenEvidence is an online tool that aggregates and synthesizes data from peer-reviewed medical studies, then producing a response to a user's questions using generative AI.
- Conditions
- AI (Artificial Intelligence), Large Language Model, Generative Artificial Intelligence
- Trial name
- NCT07199231
- Testing
- AI clinical reference tool
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance