Clinical trials: Comorbidities and Coexisting Conditions
Breast Cancer, Comorbidities and Coexisting Conditions
Streamlined Geriatric and Oncological Evaluation Based On IC Technology
The primary objective of GERONTE STUDY is to evaluate the effectiveness of the GERONTE, ICT-based, integrated care pathway to improve patient 6-month quality of life, in France.
- Conditions
- Breast Cancer, Comorbidities and Coexisting Conditions, Lung Cancer, Colorectal Cancer
- Trial name
- FRONE (NCT05720910)
- Testing
- GERONTE
- Where
- 11 sites in France
- Volunteers
- 720 people
- Sponsor
- Institut Bergonié
Congenital Heart Disease, Comorbidities and Coexisting Conditions
Congenital Heart Initiative-Redefining Outcomes and Navigation to Adult Centered Care
Congenital heart defects (CHDs) are a heterogeneous group of rare diseases of varying severity, each diagnosis with its unique set of co-morbidities.
- Trial name
- CHI-RON (NCT05185232)
- Testing
- Impact of gaps in care/loss to healthcare follow-up
- Where
- 16 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Herpes Zoster, Comorbidities and Coexisting Conditions
Herpes Zoster Hospitalizations in Italy
In Italy, the 2017-2019 National Immunization Plan recommended specific vaccinations for the elderly, defined as those 65 years old and older, and at-risk adults with age 50+ (adults presenting cardiovascular, respiratory, or…
- Trial name
- NCT05952271
- Testing
- Hospitalization
- Where
- Italy
- Volunteers
- 72,000 people
- Sponsor
- University of L'Aquila
Obesity, Morbid, Weight Regain After Bariatric Surgery
Weight Loss and Comorbidity Outcomes After Revisional Bariatric Surgery
Some people who have had weight-loss (bariatric) surgery do not lose enough weight, regain much of the weight they lost, see obesity-related diseases such as diabetes or high blood pressure return, or develop complications of the…
- Conditions
- Obesity, Morbid, Weight Regain After Bariatric Surgery, Insufficient Weight Loss After Bariatric Surgery, Complication of Bariatric Surgery
- Trial name
- NCT07880691
- Testing
- Revisional bariatric surgery
- Volunteers
- 96 people
- Sponsor
- Kasr El Aini Hospital
Attention Deficit Hyperactivity Disorder, Comorbidities and Coexisting Conditions
Motor Proficiency in School Age ADHD: Contribution of Different Comorbidities
In this study, aged 6-10 years, male, right hand dominant, diagnosed with ADHD, accepting to take part in the study and applying to the Child and Adolescent Psychiatry Department between October 1, 2018 - October 1, 2019 were…
- Conditions
- Attention Deficit Hyperactivity Disorder, Comorbidities and Coexisting Conditions, Motor Skills Disorders
- Trial name
- NCT04494230
- Testing
- Motor Proficiency in School Age ADHD: Contribution of Different Comorbidities
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Hacettepe University
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pulmonary Disease, Chronic Obstructive, Exacerbation Copd
REal-time Data Monitoring for Shared Adaptive, Multi-domain and Personalised Prediction and Decision Making for Long-term Pulmonary Care Ecosystems (RE-SAMPLE)
The main objective of this RE-SAMPLE cohort study is to identify from a real-world data (RWD) set that will be collected, a subset of data that can be potentially used as important predictors and parameters for disease…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Exacerbation Copd, Comorbidities and Coexisting Conditions
- Trial name
- RE-SAMPLE (NCT04955080)
- Where
- Netherlands
- Volunteers
- 216 people
- Sponsor
- Medisch Spectrum Twente
Comorbidities and Coexisting Conditions, Social Isolation
The PREPARE for COVID Trial
This is a randomized trial of home-based exercises versus control for older adults during the COVID-19 pandemic. The hypothesis is that participation in a home-based program will reduce the risk of adverse effects of physical…
- Trial name
- NCT04392115
- Testing
- The PREPARE program
- Volunteers
- 372 people
- Sponsor
- Ottawa Hospital Research Institute
NAFLD, Obesity, Morbid
Integrated Multi-omics Data for Personalized Treatment of Obesity-associated Fatty Liver Disease
The investigators seek to analyze the samples provided by patients with obesity-associated fatty liver disease at the multi-omics level and to integrate the results with clinical information, genotypic variants, and factors…
- Conditions
- NAFLD, Obesity, Morbid, Comorbidities and Coexisting Conditions
- Trial name
- NCT05554224
- Testing
- To propose diagnostic tests for liver diseases before surgical decisions.
- Where
- Spain
- Volunteers
- 1,104 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Cancer, Aging
Real-time Behavioral Interventions
The goal of this study is to adapt an evidence-based sedentary behavior reduction intervention for men and women living in Alabama and determine its feasibility, acceptance, and limited efficacy.
- Conditions
- Cancer, Aging, Comorbidities and Coexisting Conditions
- Trial name
- NCT04457128
- Testing
- Just-in-Time Adaptive Intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Hip Fractures, Malnutrition
Postoperative Dietary Intake of Hip Fracture Patients
The goal of this observational study is to observe the postoperative dietary intake in older adult hip fracture patients from their day of surgery (day zero) until day three inclusive.
- Conditions
- Hip Fractures, Malnutrition, Comorbidities and Coexisting Conditions, Postoperative Complications
- Trial name
- NCT06451679
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Teesside University
Stroke, Acute, Comorbidities and Coexisting Conditions
Giessen Stroke Registry
The aim of the planned study project is to assess the current situation regarding the treatment of patients with stroke. Specifically, various treatment strategies are to be associated and correlated with clinical endpoints…
- Conditions
- Stroke, Acute, Comorbidities and Coexisting Conditions, Critical Care
- Trial name
- GIST (NCT05295862)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Giessen
Severe Acute Malnutrition, HIV
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM
Malnutrition underlies 45% of child deaths, and has far-reaching educational, economic and health consequences. Severe acute malnutrition (SAM) affects 17 million children globally and is the most life-threatening form of…
- Conditions
- Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition
- Trial name
- Co-SAM (NCT05994742)
- Testing
- Rifampicin, Azithromycin, Isoniazid
- Where
- 9 sites in Kenya, Zambia and 1 more
- Volunteers
- 674 people
- Sponsor
- Queen Mary University of London
Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions
Real-world Treatment of H. Pylori Eradication in Patients with Comorbidity
Most of the studies of H. pylori eradication were conducted in academic institutes and designed to enrolled patients who did not have comorbidities.
- Conditions
- Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions, Real-world Outcome, Medication Adherence
- Trial name
- Real-world_Hp (NCT05475431)
- Testing
- The sequential therapy, The triple therapy, The hybrid therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 1,053 people
- Sponsor
- National Cheng-Kung University Hospital
Heart Failure With Preserved Ejection Fraction, Arterial Hypertension
Ambulatory Blood Pressure in HFPEF Outcomes Global Registry
Heart failure and preserved ejection fraction (HFPEF) is a disease with increasing prevalence world wide. Due to its etiological and prognostic relationship with hypertension, it is highly interesting to know the characteristics…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Arterial Hypertension, Frailty Syndrome, Comorbidities and Coexisting Conditions
- Trial name
- HFPEFGlobal (NCT04065620)
- Testing
- ambulatory blood pressure measurement
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Hospital Clinic of Barcelona
Frailty, Anesthesia
Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observational Study
Frailty is a multidimensional syndrome characterized by a decline in physiological homeostatic reserve, which translates into an increased susceptibility to adverse events and unfavorable outcomes following even small exposures…
- Conditions
- Frailty, Anesthesia, Thoracic Surgery, Cardiothoracic Surgery
- Trial name
- CAfCA (NCT05968456)
- Testing
- Data collection
- Where
- 8 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Solid Tumor, Nutrition Related Neoplasm/Cancer
Machine Learning Model to Predict HOLS and Mortality After Discharge in Hospitalized Oncologic Patients
The study aims to understand which are the most relevant parameters at admission which may allow to predict the hospital length of stay (HOLS) and mortality after discharge of oncologic hospitalized patients.
- Conditions
- Solid Tumor, Nutrition Related Neoplasm/Cancer, Comorbidities and Coexisting Conditions, Mental Status Change
- Trial name
- PLANTOLOGY (NCT05534178)
- Where
- 3 sites in Spain
- Volunteers
- 2,500 people
- Sponsor
- Vall d'Hebron Institute of Oncology
Multimorbidity, Polypharmacy
MultiPAP Plus: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
This study assesses the effectiveness of a complex intervention in young-old patients with multimorbidity and polypharmacy aimed at improving physician drug prescription in primary care, measured by hospitalization-mortality at…
- Conditions
- Multimorbidity, Polypharmacy, Comorbidities and Coexisting Conditions, Clinical Decision-Support Systems
- Trial name
- MultiPAP Plus (NCT04147130)
- Testing
- MultiPAP Plus, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 1,162 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
COVID, Severe Acute Respiratory Syndrome
Obesity and Mortality of Critically Ill Patients With COVID-19
Disproportionate impact of COVID-19 in patients with obesity is now well established. Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission.
- Conditions
- COVID, Severe Acute Respiratory Syndrome, Obesity, Comorbidities and Coexisting Conditions
- Trial name
- COV-OB-ICU (NCT04425213)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Hip Fractures, Pain, Postoperative
PENG Block vs FNB + ONB in Patients Undergoing Hip Fracture Surgery With Contraindications to Neuraxial Anesthesia
The aim of the study is to demonstrate the efficacy of PENG block as the main anesthetic technique to manage perioperative analgesia for hip fracture surgery compared to femoral and obturator nerve block in patients with…
- Conditions
- Hip Fractures, Pain, Postoperative, Coagulopathy, Comorbidities and Coexisting Conditions
- Trial name
- PENG/FNB+ONB (NCT06457880)
- Testing
- PENG BLOCK, Femoral Nerve Block, Obturator Nerve Block
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Campus Bio-Medico University