Clinical trials: Combat Disorders
PTSD, Depression
Increasing Psychological Resilience in Combat Soldiers Applying Advanced Eye-Tracking-Based Attention Bias Modification
Military service in combat units entails exposure to traumatic events that require mental adjustment. To develop and efficiently apply attention bias modification interventions aimed at enhancing soldiers' mental resilience, it…
- Conditions
- PTSD, Depression, Anxiety Disorders
- Trial name
- NCT05294848
- Testing
- Gaze-Contingent Feedback Training, Attention Bias Modification, Neutral Control
- Where
- Israel
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Posttraumatic Stress Disorder, Combat-related
Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
Three hundred (300) male or female outpatients, over 18 years of age, will be enrolled in this study to determine whether fluoxetine can be used as a treatment for Posttraumatic Stress Disorder in soldiers recently returning from…
- Trial name
- NCT00633685
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- TEMPVA Research Group, Inc.
PTSD - Post Traumatic Stress Disorder
Neural Basis of the Effect of EMDR Therapy
This study aimed to investigate the effects of a single session of Butterfly Tapping (BT), a self-administered form of alternating bilateral stimulation, on emotional reactivity and its neurophysiological correlates.
- Trial name
- EMDR-NEURO (NCT07550556)
- Testing
- Butterfly Tapping (BT), No intervention control
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Rome Foro Italico
Anxiety, Depression Disorder
Effects of Mindfulness and Self-regulation Training on Anxiety, Depression, PTSD, and Leadership
The goal of this study is to measure the effects of Mindfulness-based Mind Fitness Training (MMFT) on anxiety, depression, post-traumatic stress disorder, sleep quality, and leadership.
- Conditions
- Anxiety, Depression Disorder, PTSD - Post Traumatic Stress Disorder
- Trial name
- NCT07084233
- Testing
- Mindfulness based, trauma informed, self-regulation skills training
- Where
- Ukraine
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Georgetown University
PTSD, Post Traumatic Stress Disorder, Adolescents
MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents
The primary objective of this study is to determine the safety and feasibility of 3,4-methylenedioxymethamphetamine (MDMA) -assisted psychotherapy to treat resistant post-traumatic stress disorder (PTSD).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Adolescents, Psychotherapy
- Trial name
- NCT06353282
- Testing
- MDMA, Psychotherapy
- Where
- United States
- Sponsor
- University of California, Los Angeles
Prostatic Neoplasms, Castration-Resistant
64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617 (COMBAT)
The aim for this study is to determine the safety and efficacy of 67Cu-SAR-BBN in participants with Gastrin Releasing Peptide Receptor (GRPR)-expressing metastatic castrate resistant prostate cancer in patients who are ineligible…
- Trial name
- COMBAT (NCT05633160)
- Testing
- 64Cu-SAR-BBN, 67Cu-SAR-BBN
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Clarity Pharmaceuticals Ltd
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
Stress Disorders, Post-Traumatic
DoD PTSD November 13 - Information Processing Modification in the Treatment of PTSD
The purpose of this study is to determine whether a computerized intervention designed to change the nature of attention biases will be effective in reducing the symptoms of post traumatic stress disorder (PTSD) in American…
- Trial name
- NCT00604045
- Testing
- Attention Bias Modification (ABM), Attention Control Condition (ACC)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- San Diego State University
Posttraumatic Stress Disorder
Modafinil in the Treatment of PTSD (Posttraumatic Stress Disorder)
The purpose of this study is to determine if modafinil is more effective than placebo in the treatment of posttraumatic stress disorder (PTSD) in male combat veterans who have been deployed to Iraq or Afghanistan.
- Trial name
- NCT01726088
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Biomedical Research Foundation
PTSD - Post Traumatic Stress Disorder, Intrusive Memories of Traumatic Event(s)
Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial
The goal of this clinical trial is to learn if non-invasive neurostimulation of memory-related brain areas works to treat intrusive memory symptoms in adults patients with posttraumatic stress disorder (PTSD).
- Trial name
- NCT06639061
- Testing
- Hippocampal stimulation using repetitive transcranial magnetic stimulation (rTMS)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Posttraumatic Stress Disorder
Mindfulness and Present Centered Therapies for PTSD: Efficacy and Mechanisms
This project will study whether a new therapy that includes the practice of forms of meditation is helpful for combat veterans returning from deployments in Iraq or Afghanistan suffering with posttraumatic stress disorder (PTSD).
- Trial name
- NCT01347749
- Testing
- Mindfulness & Compassion Meditation-based Exposure Therapy, Present Centered Therapy for PTSD
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Michigan
Posttraumatic Stress Disorder
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of…
- Trial name
- VA CORT (NCT01090180)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Blast or Combat Exposure, Head Injury Trauma
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
A Pre-post Study Evaluating the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans with Sequelae of Repeated Blast Exposure.
- Trial name
- NCT04313712
- Testing
- ibogaine with magnesium treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
PTSD - Post Traumatic Stress Disorder, Sepsis
The Effect of Early Intervention on the Incidence of Posttraumatic Stress Disorder After Intensive Care Hospitalization Due to Sepsis
In recent years, the survival rate among intensive care patients has improved due to advancements in diagnosing severe infections and the use of broad-spectrum antibiotics.
- Conditions
- PTSD - Post Traumatic Stress Disorder, Sepsis, ICU
- Trial name
- NCT07707765
- Testing
- Psychiatric interview
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Barzilai Medical Center
Mental Health, COVID-19
Leveraging Community Health Workers to Combat COVID-19 and Mental Health Misinformation in Haiti, Malawi, and Rwanda
Partners In Health (PIH), in collaboration with Harvard Medical School, aims to develop and evaluate an SMS-based intervention for Community Health Workers (CHWs) to combat COVID-19 and mental health-related misinformation in…
- Conditions
- Mental Health, COVID-19, Misinformation
- Trial name
- NCT05997511
- Testing
- Card-Sorting Activity (Pre-intervention design), SMS Crafting (Pre-intervention design), SMS Messaging
- Where
- 3 sites in Haiti, Malawi and 1 more
- Volunteers
- 5,109 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
PTSD, Marital Relationship
Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder
This study seeks to enroll 76 couples in which one of the members is a combat-veteran with PTSD. Each couple will be randomized into one of two cognitive-behavioral therapies developed specifically as a treatment for PTSD-either…
- Trial name
- NCT02336971
- Testing
- CBCT for PTSD, Prolonged Exposure
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- Toronto Metropolitan University
PTSD - Post Traumatic Stress Disorder
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial
Post-traumatic stress disorder (PTSD), affecting approximately 6% of the general population and up to one-third of individuals exposed to combat zones and disasters, is a significant contributor to morbidity and mortality among…
- Trial name
- NCT07473362
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- Medical Corps, Israel Defense Force
Sarcopenia
Omega-3 Fatty Acids to Combat Sarcopenia
The purpose of this study is to determine how omega-3 fatty acids influence muscle protein metabolism and mitochondrial physiology in the context of human aging.
- Trial name
- NCT02103842
- Testing
- Omega-3 fatty acids
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Post Traumatic Stress Disorder PTSD
The Effectiveness of Guided Imagery on PCL-5 Scores in Adult Women With Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) affects a significant portion of the population, with about 13 million Americans diagnosed in 2020. Women are twice as likely to have PTSD than men.
- Trial name
- PTSD (NCT06669442)
- Testing
- Guided Imagery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Nova Southeastern University