Clinical trials: Colorectal Cancer Liver Metastases (CRLM)
Colorectal Cancer Metastatic
Neoadjuvant Safety of Sintilimab + XELOX + Bevacizumab in PMMR/MSS CRLM Patients
This prospective, single arm study aims to evaluate the preoperative neoadjuvant safety of Sintilimab combined with XELOX plus bevacizumab in colorectal patients with liver metastasis and pMMR/MSS status.
- Trial name
- NCT04940546
- Testing
- Sintilimab, Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Colorectal Neoplasms Malignant
Localized Treatment Versus Palliative Chemotherapy in CRC Patients With 10 or More CRLM
The goal of this clinical trial is to investigate the effectiveness of localized interventions in improving the 5-year survival rate for colorectal cancer patients with ≥10 liver metastases.
- Trial name
- NCT06208371
- Testing
- Surgical resection and/or ablation therapy and/or SBRT, Palliative Chemotherapy
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Liver Metastases
Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM
HARVEST is an investigator-initiated prospective randomized controlled study comparing adjuvant intravenous systemic chemotherapy with or without HAI- floxuridine (FUDR) in CRC patients post-liver metastasectomy.
- Conditions
- Colorectal Cancer, Liver Metastases, HAI
- Trial name
- NCT03500874
- Testing
- FUDR, Oxaliplatin, Leucovorin
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Sun Yat-sen University
Chronic Limb-Threatening Ischemia, Colorectal Carcinoma
Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer
Colorectal cancer (CRC) and chronic limb-threatening ischemia (CLTI) are relatively frequent and potentially fatal diseases. However, studies that are comparing clinical outcomes between CRC and CLTI patients in more advanced…
- Conditions
- Chronic Limb-Threatening Ischemia, Colorectal Carcinoma, Colorectal Carcinoma Metastatic in the Liver
- Trial name
- NCT05116696
- Testing
- For chronic limb-threatening ischemia (CLTI) patients revascularisation surgery; for colorectal liver metastasis (CRLM) patients metastatic liver surgery
- Where
- Serbia
- Volunteers
- 836 people
- Sponsor
- Clinical Centre of Serbia
Colorectal Cancer Metastatic
Efficacy and Safety of DEB-TACE Combined With HAIC Versus HAIC Alone in Patients With Unresectable CRLM
Retrospective evaluation of the efficacy and safety of DEB-TACE combined with HAIC versus HAIC alone in patients with unresectable colorectal liver metastases (CRLM)
- Trial name
- NCT07031570
- Volunteers
- 500 people
- Sponsor
- Peking University Cancer Hospital & Institute
Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM)
A Single-Arm, Phase II Study of Retlirafusp Alfa in Combination With XELOX and Bevacizumab for the First-Line Treatment of Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM)
This single-arm phase II trial enrolls patients with RAS-mutant, microsatellite-stable (MSS) unresectable colorectal cancer liver metastases receiving first-line treatment with Retlirafusp alfa combined with XELOX (capecitabine…
- Trial name
- NCT07797244
- Testing
- Retlirafusp alfa+XELOX+Bevacizumab Treatment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Dai, Guanghai
Colorectal Cancer (CRC), Colorectal Cancer Liver Metastases (CRLM)
MRD-Guided Surveillance in Resectable Stage IV Metastatic Colorectal Cancer (SURVEILLANCE-II)
This study aims to explore the relationship between minimal residual disease (MRD) status and disease recurrence in patients with resectable stage IV metastatic colorectal cancer (mCRC).
- Trial name
- SURII (NCT06879886)
- Volunteers
- 181 people
- Sponsor
- Fudan University
Colorectal Cancer Liver Metastases (CRLM)
AK104 Plus Radiotherapy Combined With Standard Therapy Versus Standard Therapy as First-Line Treatment for pMMR/MSS CRLM (APSOC)
This is a prospective, randomized controlled, single-center phase II clinical study. It aims to compare the efficacy of AK104 plus radiotherapy combined with standard therapy versus standard therapy as first-line treatment for…
- Trial name
- APSOC (NCT07544784)
- Testing
- AK104 with radiotherapy, Standard of therapy
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Fudan University
Colon Cancer Liver Metastases, Liver Neoplasms
Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) vs. Two-Stage Hepatectomy (TSH) for Marginally Resectable Colorectal Liver Metastases (CRLM)
Surgical resection has offered the best option for prolonged survival in patients with colorectal liver metastases. Limiting factor for major liver resections is the size of the future liver remnant (FLR).
- Conditions
- Colon Cancer Liver Metastases, Liver Neoplasms, Liver Diseases, Secondary Malignant Neoplasm of Liver
- Trial name
- ALPPSforCRLM (NCT02758977)
- Testing
- ALPPS, TWO STAGE HEPATECTOMY
- Where
- Switzerland
- Volunteers
- 214 people
- Sponsor
- University of Zurich
Colorectal Liver Metastasis (CRLM), Histopathological Growth Patterns (HGPs)
Deep Learning-Based Analysis of Colorectal Cancer Pathology Images: An Innovative Approach for Predicting Colorectal Cancer Subtypes
Colorectal cancer (CRC) is a leading cause of mortality in China, with metastasis significantly contributing to poor outcomes. Histopathological growth patterns (HGPs) in colorectal liver metastasis (CRLM) provide vital…
- Conditions
- Colorectal Liver Metastasis (CRLM), Histopathological Growth Patterns (HGPs), Artificial Intelligence (AI) in Diagnosis, Vision Transformer (ViT)
- Trial name
- NCT06936098
- Testing
- CRLM surgery
- Where
- China
- Volunteers
- 431 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Long-term Oncologic Outcome of MILS in Patients With CRLM and Prognostic Indicators
Minimally Invasive Liver Surgery for Metastases From Colorectal Cancer: Oncologic Outcome and Prognostic Factors
Only few reports exist on long-term survival after minimally invasive liver surgery (MILS for colorectal liver metastases. No data are available assessing prognostic factors in the era of current modern treatment strategies.
- Trial name
- NCT01356706
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- University Hospital, Gasthuisberg
Colorectal Cancer Liver Metastases (CRLM), ctDNA
Circulating Tumor DNA Methylation-Guided Adjuvant Therapy Decision-Making in Patients With Resectable Colorectal Cancer Liver Metastases After Resection
This is a prospective, randomized, controlled, multicenter phase II trial evaluating whether circulating tumor DNA (ctDNA) methylation-guided adjuvant therapy improves outcomes after R0 resection of colorectal cancer liver…
- Trial name
- LEGEND (NCT07917104)
- Testing
- Circulating Tumor DNA Methylation Testing, Conventional Postoperative Treatment Strategy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Fudan University
Colorectal Cancer Liver Metastases (CRLM), Metastatic Colorectal Carcinoma (mCRC)
Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases
Colorectal cancer is the third most common malignancy worldwide, and prognosis largely depends on how effectively metastatic disease is managed.
- Trial name
- EXELION (NCT07224724)
- Testing
- EXELION
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- City of Hope Medical Center
Colorectal Neoplasms, Neoplasm Metastasis
Treatment of Colorectal Liver Metastases With Immunotherapy and Bevacizumab
Liver is the most common site of metastases from colorectal cancer. Neoadjuvant chemotherapy with targeted agents is usually recommended for borderline-resectable liver metastases that are technically difficult to resect for…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- CLIMB (NCT03698461)
- Testing
- Atezolizumab, Bevacizumab, Oxaliplatin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver
HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization
This phase IIb trial tests the effect of HRX215 in treating patients with colorectal cancer that has spread from where it first started to the liver (liver metastasis) after undergoing a portal vein embolization (PVE).
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Resectable Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- NCT07612007
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Colorectal Cancer, Liver Metastases
Dose Finding, Efficacy and Immunological Response of IP-001 Following MWA or IRE for CRLM
The primary objectives of this phase I/II, prospective clinical trial, are to assess the optimal dose, efficacy, safety and immunological effect of ablation and intra-tumoral injection of a novel immuno-adjuvant (IP-001) for…
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer
- Trial name
- INJECTABL-II (NCT06630624)
- Testing
- IP-001
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- M.R. Meijerink
Colorectal Cancer, Liver Metastases
Cetuximab+mFOLFOX6 VS. mFOLFOX6 Alone in RAS/BRAF Wild Type Patients With High-Risk Resectable CRLM
For patients with initially resectable colorectal cancer liver metastases who have high-risk factors, neoadjuvant therapy is currently considered a consensus approach.
- Trial name
- NCT05948072
- Testing
- mFOLFOX6 + Cetuximab, mFOLFOX 6
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Colorectal Cancer (Diagnosis), Colorectal Liver Metastasis (CRLM)
Feasibility of Circulating Tumour DNA (ctDNA) Analysis Using Automated Capillary Blood Sampling
The goal of this observational study is to investigate whether circulating tumor-derived DNA (ctDNA) can be reliably detected and analyzed in blood obtained through automated capillary sampling in adult patients (≥21 years) with…
- Conditions
- Colorectal Cancer (Diagnosis), Colorectal Liver Metastasis (CRLM), Circulating Tumor DNA (ctDNA)
- Trial name
- ctDNA TAP (NCT07310537)
- Testing
- Blood Collection - TAP® Device, Blood Collection - Venous
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Erasmus Medical Center
Colorectal Cancer Liver Metastasis
Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Unresectable CRLM
To date no prospective trials have been completed that demonstrated whether RFA is an effective adjunct to systemic chemotherapy (target therapy) with respect to advantages in overall survival compared with chemotherapy (target…
- Trial name
- NCT03127072
- Testing
- Radiofrequency Ablation (RFA), chemotherapy ± target therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Colorectal Cancer Liver Metastases (CRLM)
AI-Based Prediction of Liver Metastasis in Colorectal Cancer (A Retrospective Study)
This multicenter, retrospective study aims to develop and validate a multimodal deep learning model for predicting the risk of metachronous liver metastasis in patients with stage I-III colorectal cancer following curative…
- Trial name
- NCT07399236
- Testing
- Multimodal Deep Learning Model Analysis
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Tongji Hospital