Clinical trials: Color Vision Defects
Achromatopsia
Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGB3 Achromatopsia (A Clarity Clinical Trial)
This will be a non-randomized, open-label, Phase 1/2 study of the safety and efficacy of AGTC-401 administered to one eye by subretinal injection in individuals with achromatopsia caused by mutations in the CNGB3 gene.
- Trial name
- NCT02599922
- Testing
- rAAV2tYF-PR1.7-hCNGB3
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Beacon Therapeutics
Alcohol Use Disorder
Alcohol Use Disorder and Cannabidiol
This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum CBD and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants with alcohol use…
- Trial name
- NCT05613608
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Colorado, Denver
Tinnitus
Tinnitus Treatment by Structured Cognitive Behavioral Therapy
Test of hypothesis that in contrast to non-treatment tinnitus specific cognitive behavioral therapy intervention procedures that are manualized and structured within the disease management program TCP are effective.
- Trial name
- TCP (NCT00719940)
- Testing
- Cognitive behavioral therapy, Waiting group
- Where
- 4 sites in Germany
- Volunteers
- 286 people
- Sponsor
- University Hospital Tuebingen
Complex Post-Traumatic Stress Disorder
Patient-centered Modular CBT for CPTSD: A Randomised Controlled Pilot Study
Modular Patient Centred CBT (MPC) for Complex PTSD (CPTSD) is a manualized psychotherapy programme that consists of five treatment modules addressing 1) Affect dysregulation, 2) Disturbed relationships, 3) Negative self-concept…
- Trial name
- PACE pilot RCT (NCT05259592)
- Testing
- Psychotherapy
- Where
- 5 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Danish Veterans Centre
Post Traumatic Stress Disorder
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder
The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology.
- Trial name
- NCT04197102
- Testing
- CBD Isolate, CBD Broad Spectrum
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Color Blindness, Color Vision Defects
Impact of Color Correcting Lenses on Color Vision Deficiency
To demonstrate improved color vision in subjects with color vision deficiencies while wearing color-correcting lenses and after color-correcting lense use.
- Conditions
- Color Blindness, Color Vision Defects, Color Blindness, Green, Color Blindness, Red
- Trial name
- NCT05463016
- Testing
- Experimental Group 1: Color Correcting Lenses, Color Correcting Lenses in Subjects with Normal Color Vision
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Dyspareunia
CBT Group Treatment for Women With Dyspareunia
The current study will employ a group CBT treatment program of 10 group sessions and 3 individual couple sessions targeting the thoughts, emotions, behaviors and couple interactions associated with the experience of dyspareunia.
- Trial name
- NCT03427255
- Testing
- CBT group treatment-plus, Waiting-list control condition
- Where
- 3 sites in Netherlands, Sweden
- Volunteers
- 160 people
- Sponsor
- Örebro University, Sweden
Smoking Cessation
Cognitive-Behavioral Therapy and Hypnotherapy for Smoking Cessation
Intensive cognitive-behaviour interventions (CBT) combined with pharmacotherapy for smoking cessation are well established and have been proved to be efficacious.
- Trial name
- CBT-HT (NCT01129999)
- Testing
- Cognitive-Behavioral Therapy, Hypnotherapy
- Where
- Germany
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Attention Deficit Hyperactivity Disorder
Efficacy of Neurofeedback Training in Adults With ADHD
Neurofeedback training (NFT) has been frequently investigated as an alternative treatment for ADHD mainly in children and adolescents.
- Trial name
- NCT01883765
- Testing
- Neurofeedback active, Metacognitive Training
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University Hospital Tuebingen
Smoking
The Effect of Emotional Freedom Techniques (EFT) in Smokers Failing a Smoking Cessation Program
The National Health Service (NHS) stop smoking service at the Central Lancashire NHS Trust serves a diverse population of smokers, with a very good quit rate and high standards.
- Trial name
- NCT00981396
- Testing
- EFT (Emotional Freedom Techniques), CBT (Cognitive Behavioral Therapy)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Bowel; Stricture
Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel
To determine the safety and efficacy of GIE Medical's ProTractX3™ TTS DCB for the treatment of recurrent benign bowel strictures.
- Trial name
- PATENT-B (NCT05561127)
- Testing
- GIE Medical ProTractX3 TTS DCB, Control
- Where
- 33 sites in United States
- Volunteers
- 171 people
- Sponsor
- GIE Medical
Forehead; Wound
Topical CBD Scar Outcomes Study
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
- Trial name
- TOPSCAR (NCT05650697)
- Testing
- Group 1 cannabidiol (CBD) with silicone ointment, Group 2 silicone patch
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Oklahoma
Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness)
Effect of Presbyopia Correction on Livelihood and Repayment Among Solar Customers in Western Region, Kenya
With age, people lose the ability to see things that are near them clearly. This is known as presbyopia. Although this is a normal ageing process, it can be corrected with near vision eyeglasses - colloquially known as reading…
- Conditions
- Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness), Repayment Behaviour, Livelihoods
- Trial name
- NCT06774183
- Testing
- Near vision glasses for presbyopia correction
- Volunteers
- 1,085 people
- Sponsor
- Dot Glasses Kenya
Achromatopsia
Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGA3 Achromatopsia (A Clarity Clinical Trial)
This will be a non-randomized, open-label, Phase 1/2 study of the safety and efficacy of AGTC-402, administered to one eye by subretinal injection in individuals with achromatopsia caused by mutations in the CNGA3 gene.
- Trial name
- NCT02935517
- Testing
- AGTC-402
- Where
- 6 sites in United States, Israel
- Volunteers
- 24 people
- Sponsor
- Beacon Therapeutics
Disabilities, Visual Impairment and Blindness (Excl Colour Blindness)
Study Protocol: The Jerte Valley as an Inclusive Outdoor Classroom. Smart and Active Tourism.
To promote the inclusion of people with disabilities, an outdoor intervention will be conducted involving physical activities with adolescents with and without disabilities.
- Trial name
- NCT07609459
- Testing
- Rafting, canoeing and kayaking, Divulgation
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Acceptability of Health Care
Blended Treatment för PTSD Feasibility Study
Feasibility and pilot study using within-group design with the aim of examining whether the blended psychological treatment for PTSD is acceptable for patients and therapists. 20 patients will be included and 4 therapists.
- Trial name
- NCT04881643
- Testing
- Trauma-focused cognitive behavioural therapy via a digital support
- Where
- Sweden
- Volunteers
- 17 people
- Sponsor
- Karolinska Institutet
Drug Resistant Epilepsy
Cannabis Extract in Refractory Epilepsy Study
The purpose of this study is to examine whether a low dose of CBD+THC will decrease the frequency of convulsive seizures in adults with drug-resistant epilepsy, when used in addition to standard anti-epileptic drugs (AEDs).
- Trial name
- CERES (NCT03808935)
- Testing
- Medical Cannabis
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- The Epilepsy Research Program of the Ontario Brain Institute
Bipolar Disorder
MAPP: Imagery-focused Therapy for Bipolar Disorder
Bipolar Disorder (BD) (previously known as "manic depression") is a severe mental health illness affecting at least 1% of the population and with annual NHS cost estimated at £342 million.
- Trial name
- MAPP (NCT01981018)
- Testing
- Imagery-focused Cognitive Therapy (ImCT - psychotherapy based on CBT principles)
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Vulvodynia (Chronic Vulvar Pain)
Vulvodynia Intervention: the Effect of Multimodal Treatment for Provoked Vulvodynia
The purpose of this project is to develop and evaluate a multimodal treatment for provoked vulvodynia, by addressing the following specific research questions: 1.
- Trial name
- NCT06981611
- Testing
- Vulvodynia Intervention: a multimodal treatment for provoked vulvodynia
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karlstad University