Clinical trials: Colonization
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Atopic Dermatitis
0.005% Sodium Hypochlorite Final Rinse Solution in Atopic Dermatitis
This study will determine the safety and efficacy of diluted bleach bath solution as final rinse on the reduction of Staphylococcus aureus colonization among children and adult Filipinos with mild to moderate atopic dermatitis..
- Trial name
- NCT02241174
- Testing
- Sodium Hypochlorite
- Where
- Philippines
- Volunteers
- healthy volunteers welcome
- Sponsor
- Makati Medical Center
Obesity, Microbial Colonization
Personalized Modulation of Microbiota
Intestinal flora or microbiota is the group of bacteria that live in the intestine, in a symbiotic relationship with the human body. It is estimated that human beings have around 2,000 different bacteria species.
- Conditions
- Obesity, Microbial Colonization, Nutrition Disorders
- Trial name
- NUTRIBIOTA (NCT04799223)
- Testing
- Four-foods eating guidelines, No designed-foods eating guidelines
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Microbial Colonization, Colorectal Cancer
Chemotherapy w/wo WeiLeShu in Metastatic Colorectal Cancer
A total of 50 patients with metastatic colorectal cancer will be enrolled in the study. The patients were randomly divided into the WLS-intervention group and the control group.
- Trial name
- NCT04021589
- Testing
- Weileshu, Chemotherapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhejiang University
Candidiasis, Vulvovaginal, Yeast Infection
Non-Interventional Extension to Investigate Recurrence of Vulvovaginal Candidiasis and Candida Colonization
Non-interventional extension study to investigate VVC recurrence and candida colonization following the P2 acute VVC study
- Conditions
- Candidiasis, Vulvovaginal, Yeast Infection, Mycoses, Moniliasis, Vulvovaginal
- Trial name
- NCT02888197
- Where
- 23 sites in United States
- Volunteers
- 32 people
- Sponsor
- Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Oral Health
Streptococcus Dentisani Colonization Capacity in a Split Mouth Model
Pilot study with healthy subjects to test the in vivo potential colonization ability of S. dentisani. Phase I, exploratory, prospective, mechanistic pilot clinical trial with two parallel follow-up groups.
- Trial name
- NCT03522363
- Testing
- Streptococcus dentisani CECT7746
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Microbial Colonization
DOnor Milk to REpair the Full-term Infant MIcrobiome in Infants Born Via Cesarean Section.
The objective of this novel study is to establish proof of concept using a pilot randomized controlled trial to determine the effect of DHM compared to formula supplementation on the microbiome in full-term infants who are born…
- Trial name
- DO-RE-MI C-S (NCT06177184)
- Testing
- Donor Human Milk - Nutritional Replacement
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Colonization, Multi Drug Resistant Bacteria
Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards
Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora.
- Conditions
- Colonization, Multi Drug Resistant Bacteria, Hospitalized Patients
- Trial name
- NCT00520715
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Association Pour le Recherche en Infectiologie et en Médecine Interne
Colonization, Asymptomatic
A Clinical Simulation Study of a Test Material on the Anterior Nares
The objective of this study is simulate the clinical use of a test material within a 24h window. Efficacy will be simulated as the capacity of the material to reduce or clear the anterior nares bacterial population from…
- Trial name
- NCT05617729
- Testing
- Saline applied via swab, Povidone-iodine based gel
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Center for Innovation and Research Organization
Infant, Premature, Diseases
Probiotics On Resistant Bacteria Colonization In Preterm Receiving Antibiotics
In this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics.
- Trial name
- NCT02178267
- Testing
- Lactobacillus reuteri (biogai AB, Sweden)
- Volunteers
- 51 people
- Sponsor
- Baskent University
Multiple Primary Lung Cancer, Microbial Colonization
Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer
This is an exploratory, single-center, being conducted at Beijing Haidian Hospital in order to detect the relationship between microbiome of upper gastrointestinal and pathogenesis of multiple primary lung cancer.
- Trial name
- NCT06973499
- Testing
- Microbiome Profiling and Symptom Assessment
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
Infection Due to Resistant Organism
FMT for MDRO Colonization After Infection in Renal Transplant Recipients
Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical…
- Trial name
- PREMIX (NCT02922816)
- Testing
- Fecal Microbiota Transplant (FMT), Bowel preparation, Stool or perirectal swab sampling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Necrotizing Enterocolitis, Premature Birth
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
- Trial name
- CortECS (NCT04972734)
- Testing
- premature newborns developing a NEC, premature newborns without NEC
- Where
- France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Clermont-Ferrand
Health, Subjective, Healthy
RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY
This 8-week intervention will investigate the effect of daily consumption of a fermented whey concentrate on the short-chain fatty acid profile of faeces in healthy individuals.
- Conditions
- Health, Subjective, Healthy, Microbial Colonization
- Trial name
- RIGHTWHEY (NCT03844152)
- Testing
- Fermented whey concentrate
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
HIV, Pneumococcal Infections
Mechanisms of Impaired HIV-associated B Cell and Pneumococcal Vaccine Responses
Human Immunodeficiency Virus (HIV) infection is complicated by high rates of infections and cancers which are often the cause of death rather than the HIV/acquired immune deficiency syndrome (AIDS) virus itself.
- Conditions
- HIV, Pneumococcal Infections, Pneumococcal Vaccines
- Trial name
- NCT02012309
- Testing
- PCV-13, PPSV-23
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Microbial Colonization, Infant Development
An Examination of Infants' Microbiome, Nutrition, and Development Study.
This study is examining the relationship between infant nutrition, gut health, and development. The fecal microbiota changes and develops, in large part due to the food that infants eat.
- Trial name
- IMiND (NCT03229863)
- Testing
- Sweet Potatos, Pears
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Catheterization, Peripheral
Compact Closed System Versus Mounted Open System (COSMOS)
The purpose of this study is to investigate, in a prospective and randomized fashion, the clinical performance of a closed intravenous system versus an open conventional one, with respect to ease of handling and effectiveness (as…
- Trial name
- COSMOS (NCT00665886)
- Testing
- Open Intravenous System - Vasocan®, Closed Intravenous System - Nexiva®
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Hospital San Carlos, Madrid
Bacterial Colonization
Bacterial Colonization on Nails Covered With a Methacrylic Coating
In the research, the investigators will monitor the bacterial colonization of nails coated with a methacrylic coating
- Trial name
- NCT06831305
- Testing
- Comparison of microbiological sampling on natural nails, Comparison of microbiological sampling on methacrylic nails
- Where
- Slovenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Chronic Wounds
Evaluation of the Effectiveness of Daily Pulse Lavage Therapy in Chronic Wounds
This study evaluates the effectiveness of pulse lavage therapy in decreasing bacterial counts in chronic wounds.
- Trial name
- PLI2 (NCT01500746)
- Testing
- Pulse lavage treatment, Dressing changes
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University